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- W184940243 abstract "It is difficult to pinpoint the birth of cognitive pharmacology, i.e., a study of the effect of drugs on the behavioral and neurochemical processes we attribute to higher order thinking, learning, and memory. Moreover, it is not possible here to discuss and critique the various dominant theories of cognition. Rather it would be more relevant and in-keeping with the focus of this book to consider some of the past work, primarily pharmacological, that led to current concepts that will be described in detail in some of the following chapters. One of these concepts, the “cholinergic hypothesis” of learning and memory, has undergone the most vigorous scientific scrutiny relative to other theories. The culmination of the cholinergic hypothesis is represented by the current application of the theory to the treatment of Alzheimer’s disease (AD) in the form of centrally-acting inhibitors of acetylcholinesterase (AChE), the enzyme that degrades synaptically-released acetylcholine. Despite this important application of the hypothesis, the origin of the cholinergic theory likely derives mainly from the effects produced by anticholinergic drugs, chiefly natural products like atropine and scopolamine which are active ingredients of various medicinal and cosmetic preparations of antiquity. Perhaps one of the oldest published studies pertaining to the physiological and behavioral effects of the administration of atropinic drugs in man was the account of Gauss in 1906 pertaining to the use of hyoscine in the induction of “twilight sleep” during labor [1]." @default.
- W184940243 created "2016-06-24" @default.
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- W184940243 date "2004-01-01" @default.
- W184940243 modified "2023-09-23" @default.
- W184940243 title "The cholinergic hypothesis — past and present" @default.
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- W184940243 doi "https://doi.org/10.1007/978-3-0348-7867-8_1" @default.
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