FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1849557605> ?p ?o ?g. }

• W1849557605 endingPage "1385" @default.
• W1849557605 startingPage "1375" @default.
• W1849557605 abstract "During Dictyostelium development, the expression of some genes is dependent on cell density. This effect is mediated by soluble factors referred to as conditioned medium factors (CMFs) which the developing cells secrete at very low rates and simultaneously sense. There are at least two classes of CMFs: one is an 80 x 10(3) Mr glycoprotein and the other is a heterogeneous group of molecules, with relative molecular masses between 6.5 x 10(3) and 0.65 x 10(3). Interestingly, the two classes of molecules do not need to be combined for activity. We find that the 80 x 10(3) Mr CMF but not the small CMF is sequestered in vegetative cells. The 80 x 10(3) Mr CMF is then secreted by cells during early development, while the small CMF appears only during late development. Like the 80 x 10(3) Mr CMF, the small CMFs are trypsin-sensitive and contain N- and O-linked glycosylation. The breakdown products of a fraction containing 80 x 10(3) Mr CMF cochromatographed from a Sephadex G-50 column and a reverse-phase HPLC column with small CMFs. The specific activity of CMF increases roughtly 100-fold upon breakdown. The results suggest that, during differentiation, the slowly diffusing 80 x 10(3) Mr CMF is first produced from a precursor pool already present in vegetative cells, allowing differentiation of only those cells in the immediate vicinity of the aggregation center. The breakdown of 80 x 10(3) Mr CMF to a faster-diffusing, higher specific activity form then might enable cells farther from the aggregation center to differentiate." @default.
• W1849557605 created "2016-06-24" @default.
• W1849557605 creator A5037213535 @default.
• W1849557605 creator A5072912003 @default.
• W1849557605 creator A5076340608 @default.
• W1849557605 creator A5082244643 @default.
• W1849557605 date "1991-12-01" @default.
• W1849557605 modified "2023-09-27" @default.
• W1849557605 title "Regulation and processing of a secreted protein that mediates sensing of cell density in <i>Dictyostelium</i>" @default.
• W1849557605 cites W1498071142 @default.
• W1849557605 cites W1814947595 @default.
• W1849557605 cites W1939696616 @default.
• W1849557605 cites W1962196811 @default.
• W1849557605 cites W1966637743 @default.
• W1849557605 cites W1967609304 @default.
• W1849557605 cites W1970699179 @default.
• W1849557605 cites W1977577504 @default.
• W1849557605 cites W1981613908 @default.
• W1849557605 cites W1986465767 @default.
• W1849557605 cites W1993212786 @default.
• W1849557605 cites W1995834487 @default.
• W1849557605 cites W2001681075 @default.
• W1849557605 cites W2002104214 @default.
• W1849557605 cites W2004665876 @default.
• W1849557605 cites W2011369393 @default.
• W1849557605 cites W2012267015 @default.
• W1849557605 cites W2013940605 @default.
• W1849557605 cites W2021407798 @default.
• W1849557605 cites W2033630403 @default.
• W1849557605 cites W2039908784 @default.
• W1849557605 cites W2046091883 @default.
• W1849557605 cites W2048201630 @default.
• W1849557605 cites W2053301546 @default.
• W1849557605 cites W2058818968 @default.
• W1849557605 cites W2061505961 @default.
• W1849557605 cites W2062525807 @default.
• W1849557605 cites W2063517370 @default.
• W1849557605 cites W2078147272 @default.
• W1849557605 cites W2079738554 @default.
• W1849557605 cites W2080586835 @default.
• W1849557605 cites W2081731819 @default.
• W1849557605 cites W2093011486 @default.
• W1849557605 cites W2093355482 @default.
• W1849557605 cites W2094418925 @default.
• W1849557605 cites W2110616362 @default.
• W1849557605 cites W2145518418 @default.
• W1849557605 cites W2148460267 @default.
• W1849557605 cites W2162142215 @default.
• W1849557605 cites W2189134913 @default.
• W1849557605 cites W2228706223 @default.
• W1849557605 cites W3021820070 @default.
• W1849557605 doi "https://doi.org/10.1242/dev.113.4.1375" @default.
• W1849557605 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1811950" @default.
• W1849557605 hasPublicationYear "1991" @default.
• W1849557605 type Work @default.
• W1849557605 sameAs 1849557605 @default.
• W1849557605 citedByCount "37" @default.
• W1849557605 countsByYear W18495576052012 @default.
• W1849557605 countsByYear W18495576052017 @default.
• W1849557605 countsByYear W18495576052018 @default.
• W1849557605 countsByYear W18495576052019 @default.
• W1849557605 countsByYear W18495576052020 @default.
• W1849557605 countsByYear W18495576052021 @default.
• W1849557605 crossrefType "journal-article" @default.
• W1849557605 hasAuthorship W1849557605A5037213535 @default.
• W1849557605 hasAuthorship W1849557605A5072912003 @default.
• W1849557605 hasAuthorship W1849557605A5076340608 @default.
• W1849557605 hasAuthorship W1849557605A5082244643 @default.
• W1849557605 hasBestOaLocation W18495576051 @default.
• W1849557605 hasConcept C104317684 @default.
• W1849557605 hasConcept C108625454 @default.
• W1849557605 hasConcept C148738053 @default.
• W1849557605 hasConcept C163994747 @default.
• W1849557605 hasConcept C181199279 @default.
• W1849557605 hasConcept C2775889303 @default.
• W1849557605 hasConcept C2775969001 @default.
• W1849557605 hasConcept C2777313579 @default.
• W1849557605 hasConcept C2780340462 @default.
• W1849557605 hasConcept C49039625 @default.
• W1849557605 hasConcept C55493867 @default.
• W1849557605 hasConcept C58121356 @default.
• W1849557605 hasConcept C86803240 @default.
• W1849557605 hasConcept C95444343 @default.
• W1849557605 hasConceptScore W1849557605C104317684 @default.
• W1849557605 hasConceptScore W1849557605C108625454 @default.
• W1849557605 hasConceptScore W1849557605C148738053 @default.
• W1849557605 hasConceptScore W1849557605C163994747 @default.
• W1849557605 hasConceptScore W1849557605C181199279 @default.
• W1849557605 hasConceptScore W1849557605C2775889303 @default.
• W1849557605 hasConceptScore W1849557605C2775969001 @default.
• W1849557605 hasConceptScore W1849557605C2777313579 @default.
• W1849557605 hasConceptScore W1849557605C2780340462 @default.
• W1849557605 hasConceptScore W1849557605C49039625 @default.
• W1849557605 hasConceptScore W1849557605C55493867 @default.
• W1849557605 hasConceptScore W1849557605C58121356 @default.
• W1849557605 hasConceptScore W1849557605C86803240 @default.
• W1849557605 hasConceptScore W1849557605C95444343 @default.
• W1849557605 hasIssue "4" @default.

• next