FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1849591313> ?p ?o ?g. }

• W1849591313 endingPage "287" @default.
• W1849591313 startingPage "282" @default.
• W1849591313 abstract "The dopamine receptor D4 (DRD4) gene includes several variable number of tandem repeat loci that have been suggested to modulate DRD4 gene expression patterns. Previous studies showed differential basal activity of the two most common variants of a tandem repeat (120 bp per repeat unit) located in the 5′ region adjacent to the DRD4 promoter in human cell lines. In this communication, we further characterized the ability of this polymorphic repeat to elicit tissue-, allele- and stimuli-specific transcriptional activity in vitro. The short and long variants of the DRD4 5′ tandem repeat were cloned into a luciferase reporter gene construct containing the SV40 promoter. The luciferase constructs were cotransfected with expression vectors of two ubiquitously expressed human transcription factors (TFs), CCCTC-binding factor (CTCF) and upstream stimulatory factor 2 (USF2), into human cell lines and primary cultures of neonate rat cortex and luciferase activity measured. Overexpression with these TFs resulted in differential cell- and allele-specific transcriptional activities of the luciferase constructs. The results of our experiments show that variants of this tandem repeat in the 5′ promoter of the DRD4 gene will direct differential reporter gene transcriptional activity in a cell-type-specific manner dependent on the signal pathways activated." @default.
• W1849591313 created "2016-06-24" @default.
• W1849591313 creator A5018492307 @default.
• W1849591313 creator A5061510230 @default.
• W1849591313 creator A5078085339 @default.
• W1849591313 date "2012-11-07" @default.
• W1849591313 modified "2023-10-17" @default.
• W1849591313 title "Allele-specific transcriptional activity of the variable number of tandem repeats in 5′ region of the<i>DRD4</i>gene is stimulus specific in human neuronal cells" @default.
• W1849591313 cites W1870049385 @default.
• W1849591313 cites W1885356150 @default.
• W1849591313 cites W1966916377 @default.
• W1849591313 cites W1984463151 @default.
• W1849591313 cites W1998670974 @default.
• W1849591313 cites W1999098976 @default.
• W1849591313 cites W2001515224 @default.
• W1849591313 cites W2002855843 @default.
• W1849591313 cites W2017195704 @default.
• W1849591313 cites W2026682685 @default.
• W1849591313 cites W2029256497 @default.
• W1849591313 cites W2047022382 @default.
• W1849591313 cites W2057597572 @default.
• W1849591313 cites W2083534345 @default.
• W1849591313 cites W2100929317 @default.
• W1849591313 cites W2105293054 @default.
• W1849591313 cites W2137602939 @default.
• W1849591313 cites W2141408320 @default.
• W1849591313 cites W2152149075 @default.
• W1849591313 cites W2160379721 @default.
• W1849591313 cites W2165601675 @default.
• W1849591313 cites W45653763 @default.
• W1849591313 doi "https://doi.org/10.1111/j.1601-183x.2012.00857.x" @default.
• W1849591313 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23013251" @default.
• W1849591313 hasPublicationYear "2012" @default.
• W1849591313 type Work @default.
• W1849591313 sameAs 1849591313 @default.
• W1849591313 citedByCount "10" @default.
• W1849591313 countsByYear W18495913132014 @default.
• W1849591313 countsByYear W18495913132015 @default.
• W1849591313 countsByYear W18495913132016 @default.
• W1849591313 countsByYear W18495913132020 @default.
• W1849591313 crossrefType "journal-article" @default.
• W1849591313 hasAuthorship W1849591313A5018492307 @default.
• W1849591313 hasAuthorship W1849591313A5061510230 @default.
• W1849591313 hasAuthorship W1849591313A5078085339 @default.
• W1849591313 hasConcept C101762097 @default.
• W1849591313 hasConcept C104317684 @default.
• W1849591313 hasConcept C111335760 @default.
• W1849591313 hasConcept C111936080 @default.
• W1849591313 hasConcept C138885662 @default.
• W1849591313 hasConcept C141231307 @default.
• W1849591313 hasConcept C150194340 @default.
• W1849591313 hasConcept C153911025 @default.
• W1849591313 hasConcept C161733203 @default.
• W1849591313 hasConcept C165864922 @default.
• W1849591313 hasConcept C179926584 @default.
• W1849591313 hasConcept C180754005 @default.
• W1849591313 hasConcept C27149982 @default.
• W1849591313 hasConcept C27153228 @default.
• W1849591313 hasConcept C2778760011 @default.
• W1849591313 hasConcept C41895202 @default.
• W1849591313 hasConcept C54009773 @default.
• W1849591313 hasConcept C54355233 @default.
• W1849591313 hasConcept C62944979 @default.
• W1849591313 hasConcept C86339819 @default.
• W1849591313 hasConcept C86803240 @default.
• W1849591313 hasConcept C91779695 @default.
• W1849591313 hasConceptScore W1849591313C101762097 @default.
• W1849591313 hasConceptScore W1849591313C104317684 @default.
• W1849591313 hasConceptScore W1849591313C111335760 @default.
• W1849591313 hasConceptScore W1849591313C111936080 @default.
• W1849591313 hasConceptScore W1849591313C138885662 @default.
• W1849591313 hasConceptScore W1849591313C141231307 @default.
• W1849591313 hasConceptScore W1849591313C150194340 @default.
• W1849591313 hasConceptScore W1849591313C153911025 @default.
• W1849591313 hasConceptScore W1849591313C161733203 @default.
• W1849591313 hasConceptScore W1849591313C165864922 @default.
• W1849591313 hasConceptScore W1849591313C179926584 @default.
• W1849591313 hasConceptScore W1849591313C180754005 @default.
• W1849591313 hasConceptScore W1849591313C27149982 @default.
• W1849591313 hasConceptScore W1849591313C27153228 @default.
• W1849591313 hasConceptScore W1849591313C2778760011 @default.
• W1849591313 hasConceptScore W1849591313C41895202 @default.
• W1849591313 hasConceptScore W1849591313C54009773 @default.
• W1849591313 hasConceptScore W1849591313C54355233 @default.
• W1849591313 hasConceptScore W1849591313C62944979 @default.
• W1849591313 hasConceptScore W1849591313C86339819 @default.
• W1849591313 hasConceptScore W1849591313C86803240 @default.
• W1849591313 hasConceptScore W1849591313C91779695 @default.
• W1849591313 hasIssue "2" @default.
• W1849591313 hasLocation W18495913131 @default.
• W1849591313 hasLocation W18495913132 @default.
• W1849591313 hasOpenAccess W1849591313 @default.
• W1849591313 hasPrimaryLocation W18495913131 @default.
• W1849591313 hasRelatedWork W1840763667 @default.
• W1849591313 hasRelatedWork W1849591313 @default.
• W1849591313 hasRelatedWork W2045115548 @default.
• W1849591313 hasRelatedWork W2078482548 @default.
• W1849591313 hasRelatedWork W2153071879 @default.

• next