Matches in SemOpenAlex for { <https://semopenalex.org/work/W1849618384> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W1849618384 endingPage "405" @default.
- W1849618384 startingPage "395" @default.
- W1849618384 abstract "Certain Rauwolfia alkaloids (reserpinine, rescinnamine, serpentine, ajmaline and ajmalicine) were investigated for their central vasodepressant effects in cats by the same technics as previously employed in this laboratory for reserpine and alseroxylon. 5-Hydroxytryptamine (5-HT, serotonin) was also included in this study because it has been implicated as a mediator in the action of reserpine and rescinnamine. Pressor responses were elicited from the medullary vasopressor locus, with the sterotaxic technic, and from the spinal cord by spinal fluid (CSF) compression after high spinal ligation. Epinephrine (or levarterenol) was used to determine peripheral drug effects on vascular reactivity. The results indicate that the alkaloids rescinnamine and reserpinine are to be classed with reserpine because of their mildly depressant effect on electrically induced medullary pressor responses, and their lack of effect on pressor responses from spinal compression and from the injection of epinephrine. Similarly, the alkaloids serpentine and ajmaline can be classed with alseroxylon because of their primary depressant effect on pressor responses evoked by spinal compression as well as their potent depressant effect on medullary responses. These two alkaloids, like those in the reserpine group, did not appreciably affect pressor responses to epinephrine. Ajmalicine has been demonstrated, by the cross-circulation technic, to possess central depressant activity in addition to its adrenergic blocking activity. 5-HT has been included in the reserpine group because of certain properties which serotonin shares with reserpine, including failure to produce spinal vasomotor depression. Effects of the various alkaloids on the resting blood pressure level are complex and have been discussed in light of the central vasodepressant influences of these drugs. The results of the investigation indicate that reserpine does not contribute significantly to the pronounced hypotensive activity of alseroxylon." @default.
- W1849618384 created "2016-06-24" @default.
- W1849618384 creator A5041079132 @default.
- W1849618384 creator A5054221588 @default.
- W1849618384 date "1957-03-01" @default.
- W1849618384 modified "2023-09-23" @default.
- W1849618384 title "Comparative effects of various Rauwolfia alkaloids on centrally evoked vasopressor responses." @default.
- W1849618384 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/13417095" @default.
- W1849618384 hasPublicationYear "1957" @default.
- W1849618384 type Work @default.
- W1849618384 sameAs 1849618384 @default.
- W1849618384 citedByCount "6" @default.
- W1849618384 countsByYear W18496183842019 @default.
- W1849618384 countsByYear W18496183842021 @default.
- W1849618384 crossrefType "journal-article" @default.
- W1849618384 hasAuthorship W1849618384A5041079132 @default.
- W1849618384 hasAuthorship W1849618384A5054221588 @default.
- W1849618384 hasConcept C126322002 @default.
- W1849618384 hasConcept C134018914 @default.
- W1849618384 hasConcept C170493617 @default.
- W1849618384 hasConcept C185592680 @default.
- W1849618384 hasConcept C2775859304 @default.
- W1849618384 hasConcept C2775864247 @default.
- W1849618384 hasConcept C2777025580 @default.
- W1849618384 hasConcept C2777842393 @default.
- W1849618384 hasConcept C42219234 @default.
- W1849618384 hasConcept C42251903 @default.
- W1849618384 hasConcept C71924100 @default.
- W1849618384 hasConcept C98274493 @default.
- W1849618384 hasConceptScore W1849618384C126322002 @default.
- W1849618384 hasConceptScore W1849618384C134018914 @default.
- W1849618384 hasConceptScore W1849618384C170493617 @default.
- W1849618384 hasConceptScore W1849618384C185592680 @default.
- W1849618384 hasConceptScore W1849618384C2775859304 @default.
- W1849618384 hasConceptScore W1849618384C2775864247 @default.
- W1849618384 hasConceptScore W1849618384C2777025580 @default.
- W1849618384 hasConceptScore W1849618384C2777842393 @default.
- W1849618384 hasConceptScore W1849618384C42219234 @default.
- W1849618384 hasConceptScore W1849618384C42251903 @default.
- W1849618384 hasConceptScore W1849618384C71924100 @default.
- W1849618384 hasConceptScore W1849618384C98274493 @default.
- W1849618384 hasIssue "3" @default.
- W1849618384 hasLocation W18496183841 @default.
- W1849618384 hasOpenAccess W1849618384 @default.
- W1849618384 hasPrimaryLocation W18496183841 @default.
- W1849618384 hasRelatedWork W1970505296 @default.
- W1849618384 hasRelatedWork W1989034225 @default.
- W1849618384 hasRelatedWork W1993233489 @default.
- W1849618384 hasRelatedWork W2008119750 @default.
- W1849618384 hasRelatedWork W2015586927 @default.
- W1849618384 hasRelatedWork W2034451415 @default.
- W1849618384 hasRelatedWork W2062222390 @default.
- W1849618384 hasRelatedWork W2076596714 @default.
- W1849618384 hasRelatedWork W2090960661 @default.
- W1849618384 hasRelatedWork W2255680821 @default.
- W1849618384 hasVolume "119" @default.
- W1849618384 isParatext "false" @default.
- W1849618384 isRetracted "false" @default.
- W1849618384 magId "1849618384" @default.
- W1849618384 workType "article" @default.