Matches in SemOpenAlex for { <https://semopenalex.org/work/W1849826677> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W1849826677 endingPage "380" @default.
- W1849826677 startingPage "373" @default.
- W1849826677 abstract "The binding properties, with blood proteins, and tissue distribution of 22-oxa-1 alpha,25-dihydroxyvitamin (22-oxacalcitriol; OCT), a noncalcemic analogue of 1 alpha,25-dihydroxyvitamin D3 [1,25(OH)2D3], in rats were investigated. The binding affinity of OCT to plasma vitamin D binding protein (DBP) is extremely low and OCT mainly circulates in the blood as an intact form nonspecifically bound to lipoproteins especially to chylomicrons and low density lipoprotein (LDL). OCT intravenously injected into normal rats rats rapidly disappeared from the blood, and rapidly appeared in the bile as glucuronides of intact OCT and 1 alpha, 3 beta,20(S)-trihydroxy-9,10-secopregna-5,7,10(19)-triene (23,24,25,26, 27-pentanorOCT; pentanorOCT) as an OCT metabolite. When OCT or 1,25(OH)2D3 was injected into normal rats, significant amounts of OCT and 1,25(OH)2D3 were quickly detected in the thyroid and parathyroid glands, thymus, adrenals, liver, plasma, small intestine, kidneys, and calvaria. The detected amounts of OCT in the parathyroid glands, thymus, adrenals, liver, small intestine, and kidneys were significantly higher than the respective values for 1,25(OH)2D3 2 and/or 10 min after injection, while those of OCT in the plasma and calvaria were significantly lower than those of 1,25(OH)2D3. The in vivo rapid turn-over, nonspecific transportation, and incorporation of detectable amounts into the tissues are typical characteristics of OCT which may account for its specific activities." @default.
- W1849826677 created "2016-06-24" @default.
- W1849826677 creator A5001124321 @default.
- W1849826677 creator A5023449950 @default.
- W1849826677 creator A5031698989 @default.
- W1849826677 creator A5034846886 @default.
- W1849826677 creator A5060526712 @default.
- W1849826677 creator A5064944333 @default.
- W1849826677 creator A5068283403 @default.
- W1849826677 date "1994-03-01" @default.
- W1849826677 modified "2023-09-24" @default.
- W1849826677 title "The Binding Properties, with Blood Proteins, and Tissue Distribution of 22-Oxa-1α, 25-Dihydroxyvitamin D3, a Noncalcemic Analogue of 1α, 25-Dihydroxyvitamin D3, in Rats1" @default.
- W1849826677 cites W2413302411 @default.
- W1849826677 doi "https://doi.org/10.1093/oxfordjournals.jbchem.a124346" @default.
- W1849826677 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8056745" @default.
- W1849826677 hasPublicationYear "1994" @default.
- W1849826677 type Work @default.
- W1849826677 sameAs 1849826677 @default.
- W1849826677 citedByCount "55" @default.
- W1849826677 countsByYear W18498266772012 @default.
- W1849826677 countsByYear W18498266772015 @default.
- W1849826677 countsByYear W18498266772020 @default.
- W1849826677 countsByYear W18498266772023 @default.
- W1849826677 crossrefType "journal-article" @default.
- W1849826677 hasAuthorship W1849826677A5001124321 @default.
- W1849826677 hasAuthorship W1849826677A5023449950 @default.
- W1849826677 hasAuthorship W1849826677A5031698989 @default.
- W1849826677 hasAuthorship W1849826677A5034846886 @default.
- W1849826677 hasAuthorship W1849826677A5060526712 @default.
- W1849826677 hasAuthorship W1849826677A5064944333 @default.
- W1849826677 hasAuthorship W1849826677A5068283403 @default.
- W1849826677 hasConcept C11772777 @default.
- W1849826677 hasConcept C124490489 @default.
- W1849826677 hasConcept C126322002 @default.
- W1849826677 hasConcept C134018914 @default.
- W1849826677 hasConcept C146543888 @default.
- W1849826677 hasConcept C150903083 @default.
- W1849826677 hasConcept C153639570 @default.
- W1849826677 hasConcept C185592680 @default.
- W1849826677 hasConcept C207001950 @default.
- W1849826677 hasConcept C2776079296 @default.
- W1849826677 hasConcept C2776940978 @default.
- W1849826677 hasConcept C2777477808 @default.
- W1849826677 hasConcept C2778163477 @default.
- W1849826677 hasConcept C2780072125 @default.
- W1849826677 hasConcept C55493867 @default.
- W1849826677 hasConcept C71924100 @default.
- W1849826677 hasConcept C8243546 @default.
- W1849826677 hasConcept C86803240 @default.
- W1849826677 hasConceptScore W1849826677C11772777 @default.
- W1849826677 hasConceptScore W1849826677C124490489 @default.
- W1849826677 hasConceptScore W1849826677C126322002 @default.
- W1849826677 hasConceptScore W1849826677C134018914 @default.
- W1849826677 hasConceptScore W1849826677C146543888 @default.
- W1849826677 hasConceptScore W1849826677C150903083 @default.
- W1849826677 hasConceptScore W1849826677C153639570 @default.
- W1849826677 hasConceptScore W1849826677C185592680 @default.
- W1849826677 hasConceptScore W1849826677C207001950 @default.
- W1849826677 hasConceptScore W1849826677C2776079296 @default.
- W1849826677 hasConceptScore W1849826677C2776940978 @default.
- W1849826677 hasConceptScore W1849826677C2777477808 @default.
- W1849826677 hasConceptScore W1849826677C2778163477 @default.
- W1849826677 hasConceptScore W1849826677C2780072125 @default.
- W1849826677 hasConceptScore W1849826677C55493867 @default.
- W1849826677 hasConceptScore W1849826677C71924100 @default.
- W1849826677 hasConceptScore W1849826677C8243546 @default.
- W1849826677 hasConceptScore W1849826677C86803240 @default.
- W1849826677 hasIssue "3" @default.
- W1849826677 hasLocation W18498266771 @default.
- W1849826677 hasLocation W18498266772 @default.
- W1849826677 hasOpenAccess W1849826677 @default.
- W1849826677 hasPrimaryLocation W18498266771 @default.
- W1849826677 hasRelatedWork W153689395 @default.
- W1849826677 hasRelatedWork W1964826813 @default.
- W1849826677 hasRelatedWork W1988978450 @default.
- W1849826677 hasRelatedWork W1989914402 @default.
- W1849826677 hasRelatedWork W2128159001 @default.
- W1849826677 hasRelatedWork W2157000830 @default.
- W1849826677 hasRelatedWork W2296140483 @default.
- W1849826677 hasRelatedWork W23032388 @default.
- W1849826677 hasRelatedWork W2328668479 @default.
- W1849826677 hasRelatedWork W2434031952 @default.
- W1849826677 hasVolume "115" @default.
- W1849826677 isParatext "false" @default.
- W1849826677 isRetracted "false" @default.
- W1849826677 magId "1849826677" @default.
- W1849826677 workType "article" @default.