Matches in SemOpenAlex for { <https://semopenalex.org/work/W1849968114> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W1849968114 endingPage "9" @default.
- W1849968114 startingPage "1214" @default.
- W1849968114 abstract "Breast carcinoma is thought to arise because of multiple successive changes in the genome of the normal epithelial cells. However, little is known of the order of appearance of different types of genetic aberrations We studied the ERBB2 (Her-2/neu) and CCND1 (cyclin D1) oncogene amplification in flow cytometrically sorted diploid and nondiploid tumor cell populations by fluorescence in situ hybridization (FISH). The purity of the cell sorting was confirmed by static DNA image cytometry. Spectral karyotyping was used to define differences in a genome-wide manner between two distinctly different aneuploid cell clones found in each of two breast cancer cell lines. FISH indicated the presence of gene amplification both in diploid and nondiploid cell clones in 17 of the 21 amplification-containing tumors analyzed. The oncogene copy numbers remained unchanged throughout aneuploidization in 11 of 17 tumors. The remaining six tumors showed an increase in oncogene copy number as well as the number of chromosome 11 or 17 centromeres (the original location of CCNDI and ERBB2, respectively). Breast carcinoma cell lines MDA-157 and MDA-436 showed a significant number of chromosomal rearrangements in the near-diploid clones, which were present in duplicate in the corresponding aneuploid (polyploid) clones. These results indicate that ploidy shift, ie., aneuploidization, in breast cancer is a late genetic event which is preceded by both oncogene amplifications as well as many chromosomal rearrangements." @default.
- W1849968114 created "2016-06-24" @default.
- W1849968114 creator A5011264737 @default.
- W1849968114 creator A5011436481 @default.
- W1849968114 creator A5014200970 @default.
- W1849968114 creator A5044791514 @default.
- W1849968114 creator A5068108014 @default.
- W1849968114 date "2001-02-01" @default.
- W1849968114 modified "2023-09-23" @default.
- W1849968114 title "Chromosomal rearrangements and oncogene amplification precede aneuploidization in the genetic evolution of breast cancer." @default.
- W1849968114 cites W1664492679 @default.
- W1849968114 cites W1773921558 @default.
- W1849968114 cites W1978130851 @default.
- W1849968114 cites W2006665707 @default.
- W1849968114 cites W2019155003 @default.
- W1849968114 cites W2025047211 @default.
- W1849968114 cites W2027138627 @default.
- W1849968114 cites W2030684876 @default.
- W1849968114 cites W2032857449 @default.
- W1849968114 cites W2040316588 @default.
- W1849968114 cites W2052394372 @default.
- W1849968114 cites W2055687655 @default.
- W1849968114 cites W2062286825 @default.
- W1849968114 cites W2066891144 @default.
- W1849968114 cites W2074946370 @default.
- W1849968114 cites W2078923197 @default.
- W1849968114 cites W2088985983 @default.
- W1849968114 cites W2093531978 @default.
- W1849968114 cites W2109201907 @default.
- W1849968114 cites W2110033346 @default.
- W1849968114 cites W2124525365 @default.
- W1849968114 cites W2147330111 @default.
- W1849968114 cites W2168128370 @default.
- W1849968114 cites W56652881 @default.
- W1849968114 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11221853" @default.
- W1849968114 hasPublicationYear "2001" @default.
- W1849968114 type Work @default.
- W1849968114 sameAs 1849968114 @default.
- W1849968114 citedByCount "27" @default.
- W1849968114 countsByYear W18499681142013 @default.
- W1849968114 countsByYear W18499681142014 @default.
- W1849968114 countsByYear W18499681142017 @default.
- W1849968114 crossrefType "journal-article" @default.
- W1849968114 hasAuthorship W1849968114A5011264737 @default.
- W1849968114 hasAuthorship W1849968114A5011436481 @default.
- W1849968114 hasAuthorship W1849968114A5014200970 @default.
- W1849968114 hasAuthorship W1849968114A5044791514 @default.
- W1849968114 hasAuthorship W1849968114A5068108014 @default.
- W1849968114 hasConcept C104317684 @default.
- W1849968114 hasConcept C121608353 @default.
- W1849968114 hasConcept C143191323 @default.
- W1849968114 hasConcept C153911025 @default.
- W1849968114 hasConcept C2777542201 @default.
- W1849968114 hasConcept C2779672484 @default.
- W1849968114 hasConcept C2781018059 @default.
- W1849968114 hasConcept C29537977 @default.
- W1849968114 hasConcept C30481170 @default.
- W1849968114 hasConcept C502942594 @default.
- W1849968114 hasConcept C53226629 @default.
- W1849968114 hasConcept C54355233 @default.
- W1849968114 hasConcept C7602840 @default.
- W1849968114 hasConcept C86803240 @default.
- W1849968114 hasConceptScore W1849968114C104317684 @default.
- W1849968114 hasConceptScore W1849968114C121608353 @default.
- W1849968114 hasConceptScore W1849968114C143191323 @default.
- W1849968114 hasConceptScore W1849968114C153911025 @default.
- W1849968114 hasConceptScore W1849968114C2777542201 @default.
- W1849968114 hasConceptScore W1849968114C2779672484 @default.
- W1849968114 hasConceptScore W1849968114C2781018059 @default.
- W1849968114 hasConceptScore W1849968114C29537977 @default.
- W1849968114 hasConceptScore W1849968114C30481170 @default.
- W1849968114 hasConceptScore W1849968114C502942594 @default.
- W1849968114 hasConceptScore W1849968114C53226629 @default.
- W1849968114 hasConceptScore W1849968114C54355233 @default.
- W1849968114 hasConceptScore W1849968114C7602840 @default.
- W1849968114 hasConceptScore W1849968114C86803240 @default.
- W1849968114 hasIssue "3" @default.
- W1849968114 hasLocation W18499681141 @default.
- W1849968114 hasOpenAccess W1849968114 @default.
- W1849968114 hasPrimaryLocation W18499681141 @default.
- W1849968114 hasRelatedWork W1849968114 @default.
- W1849968114 hasRelatedWork W2008708985 @default.
- W1849968114 hasRelatedWork W2061592832 @default.
- W1849968114 hasRelatedWork W2079500163 @default.
- W1849968114 hasRelatedWork W2123905089 @default.
- W1849968114 hasRelatedWork W2161649681 @default.
- W1849968114 hasRelatedWork W2161673895 @default.
- W1849968114 hasRelatedWork W2802753446 @default.
- W1849968114 hasRelatedWork W2897877078 @default.
- W1849968114 hasRelatedWork W4221052783 @default.
- W1849968114 hasVolume "61" @default.
- W1849968114 isParatext "false" @default.
- W1849968114 isRetracted "false" @default.
- W1849968114 magId "1849968114" @default.
- W1849968114 workType "article" @default.