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• W1850353402 abstract "Tumour necrosis factor-alpha causes an up to 30-fold induction of GTP cyclohydrolase I (EC 3.5.4.16) activity in murine dermal fibroblasts in a dose-dependent manner. Owing to the high constitutive activities of 6-pyruvoyltetrahydropterin synthase and sepiapterin reductase (EC 1.1.1.153), this potentiates biosynthesis of tetrahydrobiopterin. Murine macrophages already contain high activities of GTP cyclohydrolase I when unstimulated, and this is further augmented up to 4-fold by tumour necrosis factor-alpha/interferon-gamma. In Western blots an antiserum to murine liver GTP cyclohydrolase I does not stain cell extracts with high enzyme activities, suggesting that the cytokine induced peripheral form of GTP cyclohydrolase I might differ from the liver form." @default.
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• W1850353402 date "1991-12-15" @default.
• W1850353402 modified "2023-09-26" @default.
• W1850353402 title "Impact of tumour necrosis factor-<i>α</i> and interferon-<i>γ</i> on tetrahydrobiopterin synthesis in murine fibroblasts and macrophages" @default.
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• W1850353402 doi "https://doi.org/10.1042/bj2800709" @default.
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