Matches in SemOpenAlex for { <https://semopenalex.org/work/W1851004085> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W1851004085 endingPage "96" @default.
- W1851004085 startingPage "85" @default.
- W1851004085 abstract "Deactivation of the B cyclin kinase (Cdc28/Clb) drives the telophase to G1 cell cycle transition. Here we investigate one of the control pathways that contributes to kinase deactivation, involving the cell cycle-regulated production of the cdk inhibitor Sic1. We show that the cell cycle timing of SIC1 expression depends on the transcription factor Swi5, and that Swi5-dependent SIC1 expression begins during telophase. In contrast to Swi5, the related transcription factor Ace2, which can also induce SIC1 expression, is not active during telophase. The functional consequence of Swi5-regulated SIC1 expression in vivo is that both sic1Δ and swi5Δ strains have identical mitotic exit-related phenotypes. First, both are synthetically lethal with dbf2Δ, resulting in cell cycle arrest in telophase. Second, both are hypersensitive to overexpression of the B cyclin CLB2. Thus, Swi5-dependent activation of the SIC1 gene contributes to the deactivation of the B cyclin kinase, and hence exit from mitosis." @default.
- W1851004085 created "2016-06-24" @default.
- W1851004085 creator A5013215880 @default.
- W1851004085 creator A5015133572 @default.
- W1851004085 creator A5033220895 @default.
- W1851004085 creator A5050752673 @default.
- W1851004085 creator A5083403619 @default.
- W1851004085 date "1997-01-01" @default.
- W1851004085 modified "2023-10-11" @default.
- W1851004085 title "The Swi5 Transcription Factor of <i>Saccharomyces cerevisiae</i> Has a Role in Exit From Mitosis Through Induction of the cdk-Inhibitor Sic1 in Telophase" @default.
- W1851004085 doi "https://doi.org/10.1093/genetics/145.1.85" @default.
- W1851004085 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1207787" @default.
- W1851004085 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9017392" @default.
- W1851004085 hasPublicationYear "1997" @default.
- W1851004085 type Work @default.
- W1851004085 sameAs 1851004085 @default.
- W1851004085 citedByCount "108" @default.
- W1851004085 countsByYear W18510040852012 @default.
- W1851004085 countsByYear W18510040852013 @default.
- W1851004085 countsByYear W18510040852014 @default.
- W1851004085 countsByYear W18510040852015 @default.
- W1851004085 countsByYear W18510040852016 @default.
- W1851004085 countsByYear W18510040852017 @default.
- W1851004085 countsByYear W18510040852018 @default.
- W1851004085 countsByYear W18510040852020 @default.
- W1851004085 countsByYear W18510040852021 @default.
- W1851004085 countsByYear W18510040852022 @default.
- W1851004085 crossrefType "journal-article" @default.
- W1851004085 hasAuthorship W1851004085A5013215880 @default.
- W1851004085 hasAuthorship W1851004085A5015133572 @default.
- W1851004085 hasAuthorship W1851004085A5033220895 @default.
- W1851004085 hasAuthorship W1851004085A5050752673 @default.
- W1851004085 hasAuthorship W1851004085A5083403619 @default.
- W1851004085 hasBestOaLocation W18510040851 @default.
- W1851004085 hasConcept C104317684 @default.
- W1851004085 hasConcept C120089663 @default.
- W1851004085 hasConcept C124320809 @default.
- W1851004085 hasConcept C141561535 @default.
- W1851004085 hasConcept C1491633281 @default.
- W1851004085 hasConcept C16438837 @default.
- W1851004085 hasConcept C29537977 @default.
- W1851004085 hasConcept C502942594 @default.
- W1851004085 hasConcept C53420372 @default.
- W1851004085 hasConcept C54355233 @default.
- W1851004085 hasConcept C84815855 @default.
- W1851004085 hasConcept C86339819 @default.
- W1851004085 hasConcept C86803240 @default.
- W1851004085 hasConcept C93304396 @default.
- W1851004085 hasConcept C95444343 @default.
- W1851004085 hasConcept C9743823 @default.
- W1851004085 hasConceptScore W1851004085C104317684 @default.
- W1851004085 hasConceptScore W1851004085C120089663 @default.
- W1851004085 hasConceptScore W1851004085C124320809 @default.
- W1851004085 hasConceptScore W1851004085C141561535 @default.
- W1851004085 hasConceptScore W1851004085C1491633281 @default.
- W1851004085 hasConceptScore W1851004085C16438837 @default.
- W1851004085 hasConceptScore W1851004085C29537977 @default.
- W1851004085 hasConceptScore W1851004085C502942594 @default.
- W1851004085 hasConceptScore W1851004085C53420372 @default.
- W1851004085 hasConceptScore W1851004085C54355233 @default.
- W1851004085 hasConceptScore W1851004085C84815855 @default.
- W1851004085 hasConceptScore W1851004085C86339819 @default.
- W1851004085 hasConceptScore W1851004085C86803240 @default.
- W1851004085 hasConceptScore W1851004085C93304396 @default.
- W1851004085 hasConceptScore W1851004085C95444343 @default.
- W1851004085 hasConceptScore W1851004085C9743823 @default.
- W1851004085 hasIssue "1" @default.
- W1851004085 hasLocation W18510040851 @default.
- W1851004085 hasLocation W18510040852 @default.
- W1851004085 hasOpenAccess W1851004085 @default.
- W1851004085 hasPrimaryLocation W18510040851 @default.
- W1851004085 hasRelatedWork W1992435071 @default.
- W1851004085 hasRelatedWork W1998169068 @default.
- W1851004085 hasRelatedWork W2001902398 @default.
- W1851004085 hasRelatedWork W2030256538 @default.
- W1851004085 hasRelatedWork W2070286477 @default.
- W1851004085 hasRelatedWork W2079969332 @default.
- W1851004085 hasRelatedWork W2084554663 @default.
- W1851004085 hasRelatedWork W2102300724 @default.
- W1851004085 hasRelatedWork W2132066963 @default.
- W1851004085 hasRelatedWork W4224139465 @default.
- W1851004085 hasVolume "145" @default.
- W1851004085 isParatext "false" @default.
- W1851004085 isRetracted "false" @default.
- W1851004085 magId "1851004085" @default.
- W1851004085 workType "article" @default.