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• W185120762 abstract "The aim of this study was to observe the effects of endoscopic injections of botulinum toxin (BT) in the gastric antrum on body weight and gastric emptying in obese patients. Obese patients were selected for the study. By endoscopy, 100 U of BT type A was injected into the prepyloric antral gastric wall. Before and after treatment body weight and solid gastric emptying were evaluated. Twelve patients were included into this study. Four and twelve weeks after the treatment median values of body weight and gastric emptying did not show significant changes compared to baseline values: body weight: (- 0.5 kg and — 1.0 kg respectively, P > 0.05) and gastric retention for solids at 90 min (+ 4.5% and +10.5% respectively, P > 0.05). Abnormal gastric emptying (solid gastric retention at 90 min > 50%) was observed in 22% of patients after 4 weeks and in 25% after 12 weeks. BT injected into the gastric antrum does not seem to significantly reduce body weight or delay gastric emptying in obese patients. Le but de cette étude était d’évaluer les effets de l’injection antrale par voie endoscopique de toxine botulinique (TB) sur le poids et la vidange gastrique de malades obèses. Des malades obèses ont été inclus dans l’étude, et ont reçu par voie endoscopique 100 U de TB de type A injectées dans la paroi gastrique antrale pré-pylorique. Le poids et la vidange gastrique des solides ont été évalués avant et après traitement. Douze malades ont été inclus. Par rapport aux valeurs initiales, à 4 et 12 semaines, ni le poids (- 0,5 et 1,0 kg respectivement, P > 0,05), ni la vidange gastrique des solides (rétention des solides à 90 min: 4,5% et + 10,5% respectivement, P > 0,05), n’ont été modifiés par le traitement. Une vidange gastrique ralentie (rétention gastrique des solides à 90 min > 50%) a été observée chez 22% des malades à 4 semaines et 25% à 12 semaines. L’injection antrale de toxine botulinique ne semble pas diminuer significativement le poids ni allonger la vidange gastrique chez les malades obèses." @default.
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• W185120762 date "2005-08-01" @default.
• W185120762 modified "2023-10-17" @default.
• W185120762 title "Endoscopic injection of botulinum toxin in the gastric antrum for the treatment of obesity" @default.
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• W185120762 doi "https://doi.org/10.1016/s0399-8320(05)86349-3" @default.
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