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- W1851243786 abstract "Aim: To investigate the potential genetic effect on metformin efficacy in overweight or obese Chinese Type 2 diabetes mellitus (T2DM) patients. Patients & methods: 768 SNPs in or close to 207 genes were genotyped in 84 patients treated with metformin + glibenclamide/Xiaoke Pill. Significant SNPs were then verified in 107 recent-onset overweight or obese T2DM patients treated with metformin alone. Genotyping was done by Illumina GoldenGate Assay. Results: In the discovery stage, 22 SNPs were nominally significant. IL1B rs1143623 (p = 0.011) and EEF1A1P11-RPL7P9 rs10783050 (p = 0.021) were still significantly associated with the relative change of HbA 1c in the replication stage. Conclusion: IL1B rs1143623 and EEF1A1P11-RPL7P9 rs10783050 polymorphisms may contribute to metformin's glucose-lowing efficacy in overweight or obese Chinese T2DM patients." @default.
- W1851243786 created "2016-06-24" @default.
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- W1851243786 date "2015-09-01" @default.
- W1851243786 modified "2023-09-24" @default.
- W1851243786 title "<i>IL-1B</i>rs1143623 and<i>EEF1A1P11-RPL7P9</i>rs10783050 polymorphisms affect the glucose-lowing efficacy of metformin in Chinese overweight or obese Type 2 diabetes mellitus patients" @default.
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- W1851243786 doi "https://doi.org/10.2217/pgs.15.95" @default.
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