Matches in SemOpenAlex for { <https://semopenalex.org/work/W1851325672> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W1851325672 endingPage "948" @default.
- W1851325672 startingPage "940" @default.
- W1851325672 abstract "B10.BR mice were injected i.v. with varying doses of recombinant IFN-gamma on three consecutive days. In tissue sections of 13 organs, the distribution of Ia antigens and Ia-associated invariant chain (Ii) was studied by using an immunoperoxidase technique. In the control animal, Ia and Ii were shown to be co-expressed in most tissues. However, on Kupffer cells, a small number of hepatocytes, and a subset of lymphocytes in lymph nodes and in the splenic red pulp only Ii, and no Ia, was detectable. In contrast, strongly Ia+ interdigitating reticulum cells of T-dependent areas of lymph nodes and spleen were only weakly stained for Ii. IFN-gamma treatment resulted in a dramatic increase of MHC antigen expression throughout the body, with striking differences in the inducibility of certain tissues for Ia and Ii: Bronchial epithelium was clearly induced to express the invariant chain, whereas Ia antigens remained entirely absent. Moreover, in kidney tubules and colon epithelium, Ii was induced more broadly than Ia. In contrast to the induction of Ii on endothelial cells of larger vessels in kidney, heart, and lungs, no de novo expression of Ia or Ii in capillary endothelial cells was observed. The number of detectable Ia+/Ii+ interstitial dendritic cells considerably increased upon exposure to IFN-gamma. Neither neurons nor glial cells were induced to MHC antigen expression. Our data demonstrate that IFN-gamma applied i.v. is a potent inducer or enhancer of Ia antigens and invariant chain in a variety of cell types." @default.
- W1851325672 created "2016-06-24" @default.
- W1851325672 creator A5001117022 @default.
- W1851325672 creator A5021170936 @default.
- W1851325672 creator A5035960323 @default.
- W1851325672 creator A5037381512 @default.
- W1851325672 creator A5048977579 @default.
- W1851325672 creator A5086069152 @default.
- W1851325672 date "1986-02-01" @default.
- W1851325672 modified "2023-10-16" @default.
- W1851325672 title "Differential expression of Ia and Ia-associated invariant chain in mouse tissues after in vivo treatment with IFN-gamma." @default.
- W1851325672 doi "https://doi.org/10.4049/jimmunol.136.3.940" @default.
- W1851325672 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3079804" @default.
- W1851325672 hasPublicationYear "1986" @default.
- W1851325672 type Work @default.
- W1851325672 sameAs 1851325672 @default.
- W1851325672 citedByCount "106" @default.
- W1851325672 countsByYear W18513256722012 @default.
- W1851325672 countsByYear W18513256722013 @default.
- W1851325672 countsByYear W18513256722014 @default.
- W1851325672 countsByYear W18513256722015 @default.
- W1851325672 countsByYear W18513256722016 @default.
- W1851325672 countsByYear W18513256722017 @default.
- W1851325672 countsByYear W18513256722018 @default.
- W1851325672 countsByYear W18513256722022 @default.
- W1851325672 countsByYear W18513256722023 @default.
- W1851325672 crossrefType "journal-article" @default.
- W1851325672 hasAuthorship W1851325672A5001117022 @default.
- W1851325672 hasAuthorship W1851325672A5021170936 @default.
- W1851325672 hasAuthorship W1851325672A5035960323 @default.
- W1851325672 hasAuthorship W1851325672A5037381512 @default.
- W1851325672 hasAuthorship W1851325672A5048977579 @default.
- W1851325672 hasAuthorship W1851325672A5086069152 @default.
- W1851325672 hasConcept C128102431 @default.
- W1851325672 hasConcept C142724271 @default.
- W1851325672 hasConcept C147483822 @default.
- W1851325672 hasConcept C153911025 @default.
- W1851325672 hasConcept C159654299 @default.
- W1851325672 hasConcept C203014093 @default.
- W1851325672 hasConcept C207936829 @default.
- W1851325672 hasConcept C2780931953 @default.
- W1851325672 hasConcept C542903549 @default.
- W1851325672 hasConcept C71924100 @default.
- W1851325672 hasConcept C86803240 @default.
- W1851325672 hasConceptScore W1851325672C128102431 @default.
- W1851325672 hasConceptScore W1851325672C142724271 @default.
- W1851325672 hasConceptScore W1851325672C147483822 @default.
- W1851325672 hasConceptScore W1851325672C153911025 @default.
- W1851325672 hasConceptScore W1851325672C159654299 @default.
- W1851325672 hasConceptScore W1851325672C203014093 @default.
- W1851325672 hasConceptScore W1851325672C207936829 @default.
- W1851325672 hasConceptScore W1851325672C2780931953 @default.
- W1851325672 hasConceptScore W1851325672C542903549 @default.
- W1851325672 hasConceptScore W1851325672C71924100 @default.
- W1851325672 hasConceptScore W1851325672C86803240 @default.
- W1851325672 hasIssue "3" @default.
- W1851325672 hasLocation W18513256721 @default.
- W1851325672 hasLocation W18513256722 @default.
- W1851325672 hasOpenAccess W1851325672 @default.
- W1851325672 hasPrimaryLocation W18513256721 @default.
- W1851325672 hasRelatedWork W1964720104 @default.
- W1851325672 hasRelatedWork W1976902109 @default.
- W1851325672 hasRelatedWork W2049784275 @default.
- W1851325672 hasRelatedWork W2077128554 @default.
- W1851325672 hasRelatedWork W2093406717 @default.
- W1851325672 hasRelatedWork W2354402740 @default.
- W1851325672 hasRelatedWork W2404221170 @default.
- W1851325672 hasRelatedWork W2425319183 @default.
- W1851325672 hasRelatedWork W421608084 @default.
- W1851325672 hasRelatedWork W2183199573 @default.
- W1851325672 hasVolume "136" @default.
- W1851325672 isParatext "false" @default.
- W1851325672 isRetracted "false" @default.
- W1851325672 magId "1851325672" @default.
- W1851325672 workType "article" @default.