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• W1851566198 startingPage "941" @default.
• W1851566198 abstract "Melanoma is a deadly cancer due to its propensity to metastasize. Pharmacological inhibition of cell motility may benefit patients with cutaneous melanoma by preventing metastasis to internal organs. The Rho GTPases are signaling molecules that drive metastasis by controlling cell motility. We found RhoC to be expressed in clinical melanoma specimens and hypothesized that inhibiting its activation might prevent metastasis. Some Rho proteins, such as RhoC, depend on posttranslational geranylgeranylation for biological activity. We investigated the effect that Atorvastatin, a 3-hydroxy 3-methylglutaryl CoA (HMG-CoA) reductase inhibitor that prevents Rho geranylgeranylation, had on subcellular localization and activity of Rho proteins as well as the metastatic ability of melanoma cells. Atorvastatin inhibited Rho activation and reverted the metastatic phenotype of human melanoma cells in vitro. Moreover, Atorvastatin, at plasma levels comparable to those used to treat of hypercholesterolemia, inhibited in vivo metastasis of melanoma cells overexpressing RhoC. These results support further examination of statins for primary prophylaxis of melanoma metastasis." @default.
• W1851566198 created "2016-06-24" @default.
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• W1851566198 date "2003-10-01" @default.
• W1851566198 modified "2023-09-23" @default.
• W1851566198 title "Atorvastatin prevents RhoC isoprenylation, invasion, and metastasis in human melanoma cells." @default.
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• W1851566198 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4161126" @default.
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• W1851566198 hasPublicationYear "2003" @default.
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