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- W1851716614 abstract "Acebutolol was successfully labeled with (125) I via direct electrophilic substitution reaction. Radioiodinated acebutolol was prepared with a maximum radiochemical yield of 96.5 ± 0.3% and in vitro stability up to 72 h. The in vivo biological distribution of radioiodinated acebutolol showed high heart uptake of 37.8 ± 0.14% injected activity/g organ with low lungs and liver uptakes at 5 min post-injection. In vivo receptor blocking study was carried out in mice to evaluate its selectivity to heart. Radioiodinated acebutolol showed fast heart accumulation with high heart/liver ratio, which provides the ability for fast myocardial imaging with significant decrease in the radiation hazards risk on patients. So, radioiodinated acebutolol could be displayed as a radiotracer drug of choice in case of emergency patients for myocardial perfusion imaging." @default.
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- W1851716614 date "2014-08-01" @default.
- W1851716614 modified "2023-10-05" @default.
- W1851716614 title "Radioiodinated acebutolol as a new highly selective radiotracer for myocardial perfusion imaging" @default.
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- W1851716614 doi "https://doi.org/10.1002/jlcr.3223" @default.
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