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- W1852078320 abstract "Co-morbidity between depression and anxiety disordersis common. We investigated a broad phenotypeof co-morbid anxiety in cases of major depressivedisorder (MDD), and performed a genome-wideassociation (GWA) study in 1,621 subjects withDSM-IV and/or ICD-10 diagnosis of MDD, derivedfrom three studies: DeCC (Depression Case Control,N � 648), GENDEP (Genome-based TherapeuticDrugs for Depression, N � 413), DeNt(Depression Network, N � 306), and a sample fromBonn and Lausanne (N � 254). Depression andanxiety were assessed using the SCAN interview, anda new variable was created named SU mmary An X iety(SUX) score, defi ned as the sum of scores for thefollowing items: SCAN items 4.001 (general ratingof anxiety), 4.002 (general rating of phobia), 4.023(free-fl oating anxiety) and 4.024 (anxious forebodingwith autonomic symptoms). All subjects thereforehad a score between 0 and 8 for the worst and 2 ndworst episode, or current episode in GENDEP.SCAN item 1.002 (an anxiety screening item) wasused to confi rm subjects with no anxiety.We performed genome-wide analysis of the quantitativeSUX phenotype and a discrete trait (SUX � 0vs SUX � 1), correcting for the Europe-wide ascertainmentof cases. Five SNPs attained p-values of� 510^–6, suggesting evidence of association withanxiety: rs17221829 in the UBTFL2 gene with thequantitative SUX phenotype, rs9980603 and rs1040315in DSCAM , rs10238623 in CREB5 and rs7867155 inNCRNA0092 with the discrete SUX phenotype.In conclusion, we found no SNP conferring amajor contribution to co-morbid anxiety in MDD,analysed either as a continuous or discrete trait.Although this study highlighted several genes whichmay play a role in co-morbid anxiety, each will requirereplication in further studies to confi rm or refutetheir role." @default.
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- W1852078320 date "2010-01-01" @default.
- W1852078320 modified "2023-09-25" @default.
- W1852078320 title "Genome wide association scan of co-morbid anxiety in major depressive disorder (MDD) [Abstract]" @default.
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