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- W1852173745 abstract "Cardiovascular disease is common in COPD patients and is associated with poorer prognosis. Arterial stiffness (AS) is a validated measure of cardiovascular risk. Aim: To assess AS and endothelial dysfunction (ED) in COPD patients, to determine thier association with other clinical and cardiopulmonary functional parameters. Methods: We enrolled 41 COPD patients (64.5±7.6 yrs, FEV1 37.7±14.1%) and 34 normal control subjects (CS). Lung function, blood gases, six-minute walking distance (6MWD), nocturnal pulseoximetry, serum C-reactive protein (CRP) were measured. Assessment of AS was performed by use of digital photoplethysmography (Pulse Trace PCA 2 Micro Medical). Change in reflection index (RI) of the digital volume pulse in response to salbutamol (RISALB) and serum endotelin-1 (ET-1) were used to assess ED. Results: In COPD patients stiffness index (SI) was higher than in CS: 11.3±3.3 vs 6.9±0.9 m/s, p 0,05. The ET-1 levels were elevated in COPD patients and correlated with RISALB (r=-0.46, p=0.03). RISALB was significantly associated with mean nocturnal SpO2 (r=0.38), DLCO (r=0.45). Conclusion: AS and ED are significantly impaired in COPD patients. Decreased FEV1, 6MWD and systemic inflammation were associated with ED. Hypoxemia, elevated ET-1 level and decreased DLCO have an association with both AS and ED." @default.
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- W1852173745 date "2012-09-01" @default.
- W1852173745 modified "2023-09-28" @default.
- W1852173745 title "Arterial stiffness and endothelial dysfunction in stable COPD patients" @default.
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