Matches in SemOpenAlex for { <https://semopenalex.org/work/W1852807501> ?p ?o ?g. }
- W1852807501 abstract "Tumor necrosis factor-α (TNF-α) is a potent proinflammatory cytokine involved in a variety of disease pathologies, including ischemia/reperfusion (I/R) injuries in transplantation. The interaction of TNF-α with its cognate receptor TNF receptor I (TNFRI) results in the activation of signal transduction pathways that regulate either cell survival or cell death. Hepatocytes express TNFRI and respond to TNF-α released by resident Kupffer cells as well as leukocytes that migrate to the liver during I/R injury. Upon binding TNF-α, the hepatocyte proliferates or undergoes apoptosis or necroptosis. The decision by the cell to commit to one path or the other is not understood. The damaged tissue exhibits cell death and hemorrhaging from the influx of immune mediators. TNF-α inhibitors ameliorate the injury in animal models, suggesting that lowering (but not eliminating) TNF-α levels shifts the balance of TNF-α toward its beneficial functions.We review TNF-α signal transduction pathways and the role of TNF-α in liver I/R injury.Because TNF-α plays an important role in hepatocyte proliferation, complete inhibition of TNF-α is not desirable in treating liver I/R injury. The strategy for developing pharmacological therapies may be the identification of specific intermediates in the TNF-α/TNFR1 signal transduction pathway and directed targeting of proapoptotic and pronecroptotic events." @default.
- W1852807501 created "2016-06-24" @default.
- W1852807501 creator A5025606393 @default.
- W1852807501 creator A5038676391 @default.
- W1852807501 creator A5041121758 @default.
- W1852807501 creator A5063832474 @default.
- W1852807501 date "2013-01-01" @default.
- W1852807501 modified "2023-10-01" @default.
- W1852807501 title "Tumor Necrosis Factor-α: Life and Death of Hepatocytes During Liver Ischemia/Reperfusion Injury." @default.
- W1852807501 cites W1499321844 @default.
- W1852807501 cites W1552669957 @default.
- W1852807501 cites W1581093018 @default.
- W1852807501 cites W1600472471 @default.
- W1852807501 cites W1607777232 @default.
- W1852807501 cites W1752304426 @default.
- W1852807501 cites W1913661233 @default.
- W1852807501 cites W1966005581 @default.
- W1852807501 cites W1968854074 @default.
- W1852807501 cites W1969323641 @default.
- W1852807501 cites W1969893319 @default.
- W1852807501 cites W1972570178 @default.
- W1852807501 cites W1975155851 @default.
- W1852807501 cites W1976881265 @default.
- W1852807501 cites W1978910929 @default.
- W1852807501 cites W1979032223 @default.
- W1852807501 cites W1982213879 @default.
- W1852807501 cites W1984547206 @default.
- W1852807501 cites W1986982108 @default.
- W1852807501 cites W1988969017 @default.
- W1852807501 cites W1989783048 @default.
- W1852807501 cites W1989968713 @default.
- W1852807501 cites W1990312588 @default.
- W1852807501 cites W1990752073 @default.
- W1852807501 cites W1992328646 @default.
- W1852807501 cites W1994008257 @default.
- W1852807501 cites W1994610938 @default.
- W1852807501 cites W1997834526 @default.
- W1852807501 cites W2010449491 @default.
- W1852807501 cites W2012858316 @default.
- W1852807501 cites W2013282373 @default.
- W1852807501 cites W2013959382 @default.
- W1852807501 cites W2013981603 @default.
- W1852807501 cites W2017825229 @default.
- W1852807501 cites W2020895828 @default.
- W1852807501 cites W2021818635 @default.
- W1852807501 cites W2023133242 @default.
- W1852807501 cites W2027021865 @default.
- W1852807501 cites W2028526641 @default.
- W1852807501 cites W2033170367 @default.
- W1852807501 cites W2036528355 @default.
- W1852807501 cites W2036842448 @default.
- W1852807501 cites W2038884068 @default.
- W1852807501 cites W2043936400 @default.
- W1852807501 cites W2044237516 @default.
- W1852807501 cites W2045991166 @default.
- W1852807501 cites W2048356493 @default.
- W1852807501 cites W2049229105 @default.
- W1852807501 cites W2049378629 @default.
- W1852807501 cites W2052605153 @default.
- W1852807501 cites W2059028043 @default.
- W1852807501 cites W2059099989 @default.
- W1852807501 cites W2059444339 @default.
- W1852807501 cites W2060616340 @default.
- W1852807501 cites W2060945380 @default.
- W1852807501 cites W2062853648 @default.
- W1852807501 cites W2062949984 @default.
- W1852807501 cites W2070297702 @default.
- W1852807501 cites W2071055800 @default.
- W1852807501 cites W2074881372 @default.
- W1852807501 cites W2075429200 @default.
- W1852807501 cites W2075477970 @default.
- W1852807501 cites W2077132680 @default.
- W1852807501 cites W2078960019 @default.
- W1852807501 cites W2079777195 @default.
- W1852807501 cites W2080023466 @default.
- W1852807501 cites W2081244722 @default.
- W1852807501 cites W2082222518 @default.
- W1852807501 cites W2083906562 @default.
- W1852807501 cites W2086255604 @default.
- W1852807501 cites W2089115976 @default.
- W1852807501 cites W2089552619 @default.
- W1852807501 cites W2089573702 @default.
- W1852807501 cites W2090773420 @default.
- W1852807501 cites W2091161875 @default.
- W1852807501 cites W2093778666 @default.
- W1852807501 cites W2094207634 @default.
- W1852807501 cites W2094334993 @default.
- W1852807501 cites W2094361177 @default.
- W1852807501 cites W2094391415 @default.
- W1852807501 cites W2096287192 @default.
- W1852807501 cites W2097354544 @default.
- W1852807501 cites W2098510786 @default.
- W1852807501 cites W2098663684 @default.
- W1852807501 cites W2100178489 @default.
- W1852807501 cites W2105061188 @default.
- W1852807501 cites W2106566040 @default.
- W1852807501 cites W2107495112 @default.
- W1852807501 cites W2112823071 @default.
- W1852807501 cites W2113849978 @default.
- W1852807501 cites W2114727688 @default.