FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W185288001> ?p ?o ?g. }

• W185288001 endingPage "1234" @default.
• W185288001 startingPage "1226" @default.
• W185288001 abstract "Abstract Affinity purified anti-fibrinogen (anti-Fg) Fab fragments were used to study the mechanism of expression of alpha-granule fibrinogen on activated platelets. Low amounts of the radiolabeled anti-Fg Fab bound to unstimulated or adenosine diphosphate (ADP)-stimulated cells. They readily bound to platelets stimulated with collagen, alpha-thrombin or gamma-thrombin in the presence of divalent cations. At 1 n mol/L alpha- thrombin or 25 nmol/L gamma-thrombin, platelet fibrinogen was expressed on the surface of the cells notwithstanding the presence of AP-2, a monoclonal antibody to the glycoprotein (GP) IIb-IIIa complex, or the synthetic peptides Arg-Gly-Asp-Ser and gamma 400–411, all substances that prevented the binding of plasma fibrinogen to platelets. These results suggest that platelet fibrinogen may interact with its receptors during its translocation from the alpha-granules to the plasma membrane and, thus, not occupy the same sites as those available for plasma fibrinogen on the surface of the cell. Furthermore, we found that platelet fibrinogen was expressed on the thrombin-stimulated platelets of a Glanzmann's thrombasthenia variant that failed to bind plasma fibrinogen. Normal platelets stimulated with 5 nmol/L alpha- thrombin bound increased amounts of the anti-fg Fab, the additional expression being inhibited by the anti-GP IIb-IIIa monoclonal antibody or by Gly-Pro-Arg-Pro, an inhibitor of fibrin polymer formation. This suggests that rebinding to externally located GP IIb-IIIa complexes becomes important once fibrin is formed." @default.
• W185288001 created "2016-06-24" @default.
• W185288001 creator A5019084323 @default.
• W185288001 creator A5037283797 @default.
• W185288001 creator A5088334520 @default.
• W185288001 date "1989-04-01" @default.
• W185288001 modified "2023-09-28" @default.
• W185288001 title "Studies on the mechanism of expression of secreted fibrinogen on the surface of activated human platelets" @default.
• W185288001 cites W1234014522 @default.
• W185288001 cites W141180548 @default.
• W185288001 cites W1488959538 @default.
• W185288001 cites W1490975006 @default.
• W185288001 cites W1499867389 @default.
• W185288001 cites W1517807315 @default.
• W185288001 cites W1562376535 @default.
• W185288001 cites W1569353770 @default.
• W185288001 cites W1586958362 @default.
• W185288001 cites W1591493092 @default.
• W185288001 cites W1596275045 @default.
• W185288001 cites W1786523947 @default.
• W185288001 cites W1893651774 @default.
• W185288001 cites W1969632860 @default.
• W185288001 cites W1982176096 @default.
• W185288001 cites W1995054061 @default.
• W185288001 cites W1998192029 @default.
• W185288001 cites W2010711286 @default.
• W185288001 cites W2014166250 @default.
• W185288001 cites W2018956837 @default.
• W185288001 cites W2024455578 @default.
• W185288001 cites W2033785962 @default.
• W185288001 cites W2034893493 @default.
• W185288001 cites W2040116041 @default.
• W185288001 cites W2055625042 @default.
• W185288001 cites W2055881868 @default.
• W185288001 cites W2069934167 @default.
• W185288001 cites W2071210080 @default.
• W185288001 cites W2076567037 @default.
• W185288001 cites W2090451941 @default.
• W185288001 cites W2096835475 @default.
• W185288001 cites W2112611562 @default.
• W185288001 cites W2168110441 @default.
• W185288001 cites W2233044367 @default.
• W185288001 cites W2274636480 @default.
• W185288001 cites W2367313565 @default.
• W185288001 cites W2395410748 @default.
• W185288001 cites W2396807680 @default.
• W185288001 cites W2408412896 @default.
• W185288001 cites W2408460975 @default.
• W185288001 cites W2411994880 @default.
• W185288001 cites W2414762872 @default.
• W185288001 cites W2415630533 @default.
• W185288001 cites W2419137097 @default.
• W185288001 cites W2430265093 @default.
• W185288001 cites W2473765679 @default.
• W185288001 cites W259875153 @default.
• W185288001 cites W286388493 @default.
• W185288001 cites W3111661231 @default.
• W185288001 cites W91999869 @default.
• W185288001 cites W2521319634 @default.
• W185288001 doi "https://doi.org/10.1182/blood.v73.5.1226.1226" @default.
• W185288001 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2539213" @default.
• W185288001 hasPublicationYear "1989" @default.
• W185288001 type Work @default.
• W185288001 sameAs 185288001 @default.
• W185288001 citedByCount "53" @default.
• W185288001 countsByYear W1852880012012 @default.
• W185288001 countsByYear W1852880012015 @default.
• W185288001 countsByYear W1852880012019 @default.
• W185288001 crossrefType "journal-article" @default.
• W185288001 hasAuthorship W185288001A5019084323 @default.
• W185288001 hasAuthorship W185288001A5037283797 @default.
• W185288001 hasAuthorship W185288001A5088334520 @default.
• W185288001 hasBestOaLocation W1852880011 @default.
• W185288001 hasConcept C108625454 @default.
• W185288001 hasConcept C153911025 @default.
• W185288001 hasConcept C185592680 @default.
• W185288001 hasConcept C203014093 @default.
• W185288001 hasConcept C26828662 @default.
• W185288001 hasConcept C2777292125 @default.
• W185288001 hasConcept C2779036427 @default.
• W185288001 hasConcept C2911156200 @default.
• W185288001 hasConcept C2993802102 @default.
• W185288001 hasConcept C3018697912 @default.
• W185288001 hasConcept C54173615 @default.
• W185288001 hasConcept C55493867 @default.
• W185288001 hasConcept C86803240 @default.
• W185288001 hasConcept C89560881 @default.
• W185288001 hasConceptScore W185288001C108625454 @default.
• W185288001 hasConceptScore W185288001C153911025 @default.
• W185288001 hasConceptScore W185288001C185592680 @default.
• W185288001 hasConceptScore W185288001C203014093 @default.
• W185288001 hasConceptScore W185288001C26828662 @default.
• W185288001 hasConceptScore W185288001C2777292125 @default.
• W185288001 hasConceptScore W185288001C2779036427 @default.
• W185288001 hasConceptScore W185288001C2911156200 @default.
• W185288001 hasConceptScore W185288001C2993802102 @default.
• W185288001 hasConceptScore W185288001C3018697912 @default.
• W185288001 hasConceptScore W185288001C54173615 @default.

• next