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• W1853251113 endingPage "533" @default.
• W1853251113 startingPage "524" @default.
• W1853251113 abstract "The nonstructural protein NS-1, encoded by the parvovirus minute virus of mice, is a potent regulator of viral gene expression. NS-1 does not bind DNA in a sequence-specific manner, and the mechanism by which it modulates viral promoter function is unclear. We have used Gal4-NS-1 fusion protein constructs to identify and characterize an activating domain encoded within the C-terminal 88 amino acids of NS-1 which competes effectively with the acidic activator domain of the herpes simplex virus VP16 protein. DNA affinity chromatography and immunoprecipitation experiments demonstrate that protein-protein interactions between the transcription factor Sp1 and NS-1 are required to bind NS-1 to promoter DNA in vitro. Cotransfection of Gal4-NS-1 and Sp1-VP16 acidic activator constructs into Drosophila melanogaster Schneider cells, which lack endogenous Sp1, stimulates transcription from a minimal promoter containing five Gal4 binding sites, while single-construct transfections do not. Cotransfection of Schneider cells with wild-type NS-1 and Sp1 constructs activates transcription from a simian virus 40 promoter 10- to 30-fold over that of either construct alone. Thus, Sp1-NS-1 interactions in vivo can stimulate transcription from a heterologous promoter containing Sp1 binding sites." @default.
• W1853251113 created "2016-06-24" @default.
• W1853251113 creator A5044294966 @default.
• W1853251113 creator A5063437314 @default.
• W1853251113 date "1995-01-01" @default.
• W1853251113 modified "2023-09-26" @default.
• W1853251113 title "Transcriptional activation by the parvoviral nonstructural protein NS-1 is mediated via a direct interaction with Sp1" @default.
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• W1853251113 doi "https://doi.org/10.1128/mcb.15.1.524" @default.
• W1853251113 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/232005" @default.
• W1853251113 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7799962" @default.
• W1853251113 hasPublicationYear "1995" @default.
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