FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1853521257> ?p ?o ?g. }

• W1853521257 endingPage "229" @default.
• W1853521257 startingPage "218" @default.
• W1853521257 abstract "Hundred and ten liver biopsy specimens from various parts of the world were examined for episomal and integrated HBV-DNA sequences. In 54 patients with HBsAg chronic liver disease episomal HBV-DNA was found in 83% of HBeAg-positive patients, compared to only 22% of patients with anti-HBe. Furthermore episomal HBV-DNA in the latter predominated among the Asians. Integrated HBV-DNA was found only in 5.5% of HBeAg-positive patients but in 16.5% of patients with anti-HBe. In 28 HBsAg-positive patients with hepatoma, episomal HBV-DNA was found in 50% of HBeAg-positive patients but in only 11% of anti-HBe patients. Conversely integrated sequences were less common (25%) in HBe-Ag-positive patients than in anti-HBe patients (50%), giving an overall incidence of integration in this group of 45%. No episomal, and only one case of integrated sequences of HBV-DNA, could be detected among 10 patients with HBsAg-negative hepatoma. In addition neither episomal nor integrated HBV-DNA could be detected in 18 patients with non-HBV-related liver disease. Our data suggests that stable integration of HBV-DNA into the host's genome is not necessarily a prerequisite for the maintenance of the state of malignant transformation but may be necessary for its initiation. Alternatively, the detection of integrated HBV-DNA may represent a ‘snap shot’ of a random integration event amplified by clonal expansion promoted by other factors." @default.
• W1853521257 created "2016-06-24" @default.
• W1853521257 creator A5010854797 @default.
• W1853521257 creator A5011084756 @default.
• W1853521257 creator A5017312777 @default.
• W1853521257 creator A5023245922 @default.
• W1853521257 creator A5041631381 @default.
• W1853521257 creator A5061361973 @default.
• W1853521257 creator A5063317906 @default.
• W1853521257 creator A5070099420 @default.
• W1853521257 creator A5080092427 @default.
• W1853521257 creator A5088387371 @default.
• W1853521257 creator A5091803938 @default.
• W1853521257 date "1986-01-01" @default.
• W1853521257 modified "2023-10-18" @default.
• W1853521257 title "Integration of HBV-DNA may not be a prerequisite for the maintenance of the state of malignant transformation" @default.
• W1853521257 cites W1524961325 @default.
• W1853521257 cites W1801316304 @default.
• W1853521257 cites W1971488628 @default.
• W1853521257 cites W1978565124 @default.
• W1853521257 cites W1997754048 @default.
• W1853521257 cites W2011844018 @default.
• W1853521257 cites W2017804499 @default.
• W1853521257 cites W2019179371 @default.
• W1853521257 cites W2020887333 @default.
• W1853521257 cites W2028253108 @default.
• W1853521257 cites W2029987769 @default.
• W1853521257 cites W2034247538 @default.
• W1853521257 cites W2035845537 @default.
• W1853521257 cites W2045750882 @default.
• W1853521257 cites W2062147146 @default.
• W1853521257 cites W2063450941 @default.
• W1853521257 cites W2066022679 @default.
• W1853521257 cites W2069630717 @default.
• W1853521257 cites W2083858183 @default.
• W1853521257 cites W2096808350 @default.
• W1853521257 cites W2129923672 @default.
• W1853521257 cites W2132778265 @default.
• W1853521257 cites W2148286290 @default.
• W1853521257 cites W2154620855 @default.
• W1853521257 cites W2155961668 @default.
• W1853521257 cites W2341033220 @default.
• W1853521257 doi "https://doi.org/10.1016/s0168-8278(86)80080-0" @default.
• W1853521257 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3958473" @default.
• W1853521257 hasPublicationYear "1986" @default.
• W1853521257 type Work @default.
• W1853521257 sameAs 1853521257 @default.
• W1853521257 citedByCount "52" @default.
• W1853521257 countsByYear W18535212572014 @default.
• W1853521257 countsByYear W18535212572015 @default.
• W1853521257 countsByYear W18535212572016 @default.
• W1853521257 countsByYear W18535212572017 @default.
• W1853521257 countsByYear W18535212572018 @default.
• W1853521257 countsByYear W18535212572021 @default.
• W1853521257 countsByYear W18535212572022 @default.
• W1853521257 crossrefType "journal-article" @default.
• W1853521257 hasAuthorship W1853521257A5010854797 @default.
• W1853521257 hasAuthorship W1853521257A5011084756 @default.
• W1853521257 hasAuthorship W1853521257A5017312777 @default.
• W1853521257 hasAuthorship W1853521257A5023245922 @default.
• W1853521257 hasAuthorship W1853521257A5041631381 @default.
• W1853521257 hasAuthorship W1853521257A5061361973 @default.
• W1853521257 hasAuthorship W1853521257A5063317906 @default.
• W1853521257 hasAuthorship W1853521257A5070099420 @default.
• W1853521257 hasAuthorship W1853521257A5080092427 @default.
• W1853521257 hasAuthorship W1853521257A5088387371 @default.
• W1853521257 hasAuthorship W1853521257A5091803938 @default.
• W1853521257 hasConcept C159047783 @default.
• W1853521257 hasConcept C2522874641 @default.
• W1853521257 hasConcept C2775940106 @default.
• W1853521257 hasConcept C2777075537 @default.
• W1853521257 hasConcept C2777410769 @default.
• W1853521257 hasConcept C2780593183 @default.
• W1853521257 hasConcept C54355233 @default.
• W1853521257 hasConcept C552990157 @default.
• W1853521257 hasConcept C55493867 @default.
• W1853521257 hasConcept C86803240 @default.
• W1853521257 hasConceptScore W1853521257C159047783 @default.
• W1853521257 hasConceptScore W1853521257C2522874641 @default.
• W1853521257 hasConceptScore W1853521257C2775940106 @default.
• W1853521257 hasConceptScore W1853521257C2777075537 @default.
• W1853521257 hasConceptScore W1853521257C2777410769 @default.
• W1853521257 hasConceptScore W1853521257C2780593183 @default.
• W1853521257 hasConceptScore W1853521257C54355233 @default.
• W1853521257 hasConceptScore W1853521257C552990157 @default.
• W1853521257 hasConceptScore W1853521257C55493867 @default.
• W1853521257 hasConceptScore W1853521257C86803240 @default.
• W1853521257 hasIssue "2" @default.
• W1853521257 hasLocation W18535212571 @default.
• W1853521257 hasLocation W18535212572 @default.
• W1853521257 hasOpenAccess W1853521257 @default.
• W1853521257 hasPrimaryLocation W18535212571 @default.
• W1853521257 hasRelatedWork W1494523999 @default.
• W1853521257 hasRelatedWork W1978117953 @default.
• W1853521257 hasRelatedWork W2057567161 @default.
• W1853521257 hasRelatedWork W2062765391 @default.
• W1853521257 hasRelatedWork W2091706522 @default.
• W1853521257 hasRelatedWork W2355061249 @default.

• next