FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1853558512> ?p ?o ?g. }

• W1853558512 abstract "Increasing evidence indicates that rapamycin could be used as a potential glucocorticoid (GC) sensitizer in lymphoblastic malignancies via genetic prevention of 4E-BP1 phosphorylation. Interestingly, we found that combined rapamycin with dexamethasone can effectively reverse GC resistance in 4E-BP1 null lymphoma cells. In this study, we investigated the potential link between mTOR/p70S6K signaling pathway, glycolysis, autophagy and GC resistance.Antitumor effects of the combination of rapamycin and dexamethasone were evaluated on cell viability by MTT assay and in vivo studies, on cell cycle and apoptosis by flow cytometry, on autophagy by western blot, MDC staining and transmission electron microscopy and on cell signaling by western blot. Moreover, to test whether inhibiting glycolysis is the core mechanism in rapamycin restoring GC sensitivity, we took glycolysis inhibitor 2-deoxyglucose to replace rapamycin and then evaluated the antitumor effects in vitro.Raji cells are resistant to rapamycin (IC50 > 1000 nM) or dexamethasone (IC50 > 100 μM) treatment alone. The combination of rapamycin and dexamethasone synergistically inhibited the viability of Raji cells in vitro and in vivo by inducing caspase-dependent and -independent cell death and G0/G1 cell cycle arrest. These effects were achieved by the inhibition of mTOR/p70S6K signaling pathway, which led to the inhibition of glycolysis and the induction of autophagy. Pretreatment with pan-caspase inhibitor z-VAD-fmk or autophagy inhibitor 3-MA failed to protect the cells from combined treatment-induced death. Glycolysis inhibitor combined with dexamethasone produced a similar antitumor effects in vitro.Inhibition of mTOR/p70S6K/glycolysis signaling pathway is the key point of therapy in reversing GC resistant in Burkitt lymphoma patients." @default.
• W1853558512 created "2016-06-24" @default.
• W1853558512 creator A5008360001 @default.
• W1853558512 creator A5030774923 @default.
• W1853558512 creator A5036713963 @default.
• W1853558512 creator A5040589320 @default.
• W1853558512 creator A5045421676 @default.
• W1853558512 creator A5059665113 @default.
• W1853558512 creator A5090381708 @default.
• W1853558512 date "2015-07-20" @default.
• W1853558512 modified "2023-09-27" @default.
• W1853558512 title "Targeting mTOR/p70S6K/glycolysis signaling pathway restores glucocorticoid sensitivity to 4E-BP1 null Burkitt Lymphoma" @default.
• W1853558512 cites W1501338597 @default.
• W1853558512 cites W1974454557 @default.
• W1853558512 cites W1978114588 @default.
• W1853558512 cites W1979060986 @default.
• W1853558512 cites W1983125760 @default.
• W1853558512 cites W1988377311 @default.
• W1853558512 cites W1991241272 @default.
• W1853558512 cites W1995391763 @default.
• W1853558512 cites W2002636911 @default.
• W1853558512 cites W2002668916 @default.
• W1853558512 cites W2005557370 @default.
• W1853558512 cites W2006763554 @default.
• W1853558512 cites W2010568740 @default.
• W1853558512 cites W2013381376 @default.
• W1853558512 cites W2017813632 @default.
• W1853558512 cites W2019874087 @default.
• W1853558512 cites W2023660529 @default.
• W1853558512 cites W2024764187 @default.
• W1853558512 cites W2025887278 @default.
• W1853558512 cites W2037600362 @default.
• W1853558512 cites W2043315815 @default.
• W1853558512 cites W2044655112 @default.
• W1853558512 cites W2050297509 @default.
• W1853558512 cites W2054691377 @default.
• W1853558512 cites W2057428268 @default.
• W1853558512 cites W2072451938 @default.
• W1853558512 cites W2100495176 @default.
• W1853558512 cites W2104684296 @default.
• W1853558512 cites W2107612707 @default.
• W1853558512 cites W2108416006 @default.
• W1853558512 cites W2108752981 @default.
• W1853558512 cites W2110443482 @default.
• W1853558512 cites W2120553565 @default.
• W1853558512 cites W2128681673 @default.
• W1853558512 cites W2129585918 @default.
• W1853558512 cites W2129824771 @default.
• W1853558512 cites W2141627190 @default.
• W1853558512 cites W2150341448 @default.
• W1853558512 cites W2154354914 @default.
• W1853558512 cites W2154387196 @default.
• W1853558512 cites W2154954670 @default.
• W1853558512 cites W2155094055 @default.
• W1853558512 cites W2159717790 @default.
• W1853558512 cites W2160615487 @default.
• W1853558512 cites W2165843384 @default.
• W1853558512 cites W2172140114 @default.
• W1853558512 cites W2562572270 @default.
• W1853558512 cites W4241770029 @default.
• W1853558512 cites W4361744781 @default.
• W1853558512 doi "https://doi.org/10.1186/s12885-015-1535-z" @default.
• W1853558512 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4506760" @default.
• W1853558512 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26189041" @default.
• W1853558512 hasPublicationYear "2015" @default.
• W1853558512 type Work @default.
• W1853558512 sameAs 1853558512 @default.
• W1853558512 citedByCount "24" @default.
• W1853558512 countsByYear W18535585122016 @default.
• W1853558512 countsByYear W18535585122017 @default.
• W1853558512 countsByYear W18535585122018 @default.
• W1853558512 countsByYear W18535585122019 @default.
• W1853558512 countsByYear W18535585122020 @default.
• W1853558512 countsByYear W18535585122022 @default.
• W1853558512 countsByYear W18535585122023 @default.
• W1853558512 crossrefType "journal-article" @default.
• W1853558512 hasAuthorship W1853558512A5008360001 @default.
• W1853558512 hasAuthorship W1853558512A5030774923 @default.
• W1853558512 hasAuthorship W1853558512A5036713963 @default.
• W1853558512 hasAuthorship W1853558512A5040589320 @default.
• W1853558512 hasAuthorship W1853558512A5045421676 @default.
• W1853558512 hasAuthorship W1853558512A5059665113 @default.
• W1853558512 hasAuthorship W1853558512A5090381708 @default.
• W1853558512 hasBestOaLocation W18535585121 @default.
• W1853558512 hasConcept C185592680 @default.
• W1853558512 hasConcept C190283241 @default.
• W1853558512 hasConcept C203522944 @default.
• W1853558512 hasConcept C2780783641 @default.
• W1853558512 hasConcept C31573885 @default.
• W1853558512 hasConcept C502942594 @default.
• W1853558512 hasConcept C53227056 @default.
• W1853558512 hasConcept C55493867 @default.
• W1853558512 hasConcept C62478195 @default.
• W1853558512 hasConcept C86554907 @default.
• W1853558512 hasConcept C86803240 @default.
• W1853558512 hasConcept C95444343 @default.
• W1853558512 hasConceptScore W1853558512C185592680 @default.
• W1853558512 hasConceptScore W1853558512C190283241 @default.
• W1853558512 hasConceptScore W1853558512C203522944 @default.
• W1853558512 hasConceptScore W1853558512C2780783641 @default.

• next