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- W1853698148 abstract "Summary Receptor tyrosine kinases (RTKs) and their downstream signalling pathways have long been hypothesized to play key roles in melanoma development. A decade ago, evidence was derived largely from animal models, RTK expression studies and detection of activated RAS isoforms in a small fraction of melanomas. Predictions that overexpression of specific RTKs implied increased kinase activity and that some RTKs would show activating mutations in melanoma were largely untested. However, technological advances including rapid gene sequencing, siRNA methods and phospho‐RTK arrays now give a more complete picture. Mutated forms of RTK genes including KIT, ERBB4, the EPH and FGFR families and others are known in melanoma. Additional over‐ or underexpressed RTKs and also protein tyrosine phosphatases (PTPs) have been reported, and activities measured. Complex interactions between RTKs and PTPs are implicated in the abnormal signalling driving aberrant growth and survival in malignant melanocytes, and indeed in normal melanocytic signalling including the response to ultraviolet radiation. Kinases are considered druggable targets, so characterization of global RTK activity in melanoma should assist the rational development of tyrosine kinase inhibitors for clinical use." @default.
- W1853698148 created "2016-06-24" @default.
- W1853698148 creator A5012711576 @default.
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- W1853698148 creator A5033519199 @default.
- W1853698148 creator A5038015402 @default.
- W1853698148 creator A5087030675 @default.
- W1853698148 date "2011-03-03" @default.
- W1853698148 modified "2023-10-16" @default.
- W1853698148 title "Receptor tyrosine kinases and their activation in melanoma" @default.
- W1853698148 cites W1487917997 @default.
- W1853698148 cites W1512634984 @default.
- W1853698148 cites W1519498149 @default.
- W1853698148 cites W1526716359 @default.
- W1853698148 cites W1546275329 @default.
- W1853698148 cites W1547440110 @default.
- W1853698148 cites W1570494660 @default.
- W1853698148 cites W1594723117 @default.
- W1853698148 cites W1607548879 @default.
- W1853698148 cites W1607745684 @default.
- W1853698148 cites W1629158872 @default.
- W1853698148 cites W1639582946 @default.
- W1853698148 cites W1737235807 @default.
- W1853698148 cites W1748785506 @default.
- W1853698148 cites W1964646604 @default.
- W1853698148 cites W1966803171 @default.
- W1853698148 cites W1969603048 @default.
- W1853698148 cites W1969918683 @default.
- W1853698148 cites W1970572298 @default.
- W1853698148 cites W1972267806 @default.
- W1853698148 cites W1975078518 @default.
- W1853698148 cites W1976203623 @default.
- W1853698148 cites W1977140042 @default.
- W1853698148 cites W1977918009 @default.
- W1853698148 cites W1980394440 @default.
- W1853698148 cites W1980843814 @default.
- W1853698148 cites W1980926309 @default.
- W1853698148 cites W1982635732 @default.
- W1853698148 cites W1985737377 @default.
- W1853698148 cites W1986492134 @default.
- W1853698148 cites W1989773675 @default.
- W1853698148 cites W1992187858 @default.
- W1853698148 cites W1992866376 @default.
- W1853698148 cites W1993459211 @default.
- W1853698148 cites W1994634031 @default.
- W1853698148 cites W1996017770 @default.
- W1853698148 cites W1997795769 @default.
- W1853698148 cites W1998193510 @default.
- W1853698148 cites W1998971866 @default.
- W1853698148 cites W1999575468 @default.
- W1853698148 cites W2000008093 @default.
- W1853698148 cites W2003296338 @default.
- W1853698148 cites W2004485044 @default.
- W1853698148 cites W2008878539 @default.
- W1853698148 cites W2010480421 @default.
- W1853698148 cites W2015009944 @default.
- W1853698148 cites W2016701198 @default.
- W1853698148 cites W2018169163 @default.
- W1853698148 cites W2019496774 @default.
- W1853698148 cites W2019950585 @default.
- W1853698148 cites W2021705436 @default.
- W1853698148 cites W2023764466 @default.
- W1853698148 cites W2027174622 @default.
- W1853698148 cites W2028415754 @default.
- W1853698148 cites W2030205108 @default.
- W1853698148 cites W2030330538 @default.
- W1853698148 cites W2030440427 @default.
- W1853698148 cites W2032661897 @default.
- W1853698148 cites W2032981041 @default.
- W1853698148 cites W2033624161 @default.
- W1853698148 cites W2034048944 @default.
- W1853698148 cites W2034269086 @default.
- W1853698148 cites W2036116069 @default.
- W1853698148 cites W2038683568 @default.
- W1853698148 cites W2040434188 @default.
- W1853698148 cites W2043335448 @default.
- W1853698148 cites W2043617798 @default.
- W1853698148 cites W2047523756 @default.
- W1853698148 cites W2048754817 @default.
- W1853698148 cites W2050204464 @default.
- W1853698148 cites W2051337269 @default.
- W1853698148 cites W2054792180 @default.
- W1853698148 cites W2054799018 @default.
- W1853698148 cites W2058409986 @default.
- W1853698148 cites W2058522541 @default.
- W1853698148 cites W2060444505 @default.
- W1853698148 cites W2063539990 @default.
- W1853698148 cites W2063749929 @default.
- W1853698148 cites W2065272192 @default.
- W1853698148 cites W2071006062 @default.
- W1853698148 cites W2071329356 @default.
- W1853698148 cites W2071878863 @default.
- W1853698148 cites W2073548269 @default.
- W1853698148 cites W2074849291 @default.
- W1853698148 cites W2078338839 @default.
- W1853698148 cites W2079576402 @default.
- W1853698148 cites W2079641245 @default.
- W1853698148 cites W2080313922 @default.