FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1853905915> ?p ?o ?g. }

• W1853905915 endingPage "917" @default.
• W1853905915 startingPage "912" @default.
• W1853905915 abstract "Background:The etiology of muscle wasting in chronic obstructive pulmonary disease (COPD) is incompletely understood. We previously showed that the D rather than the I polymorphic variant of the angiotensin-converting enzyme (ACE) gene is associated with preserved quadriceps strength in COPD. If the ACE D allele influences skeletal muscle through increased ACE-related kinin degradation [and reduced activity at the bradykinin type 2 receptor (BK2R)], we might expect a similar association with the +9 BK2R genotype in this population as well. Objective:The objective was to test the hypothesis that the BK2R gene polymorphism is a determinant of fat-free mass and quadriceps strength in patients with COPD. Design:In a cross-sectional design we determined BK2R genotype, fat-free mass, and quadriceps strength in 110 COPD patients with a mean (±SD) predicted forced expiratory volume in 1 s of 34.3 ± 16.4% and in 104 healthy age-matched control subjects. Results:The mean (±SD) fat-free mass index (in kg/m2) was significantly lower in 37 patients homozygous for the +9 allele than in carriers of the −9 allele (15.7 ± 1.8 compared with 16.7 ± 2.3; P = 0.038); the same pattern was true for quadriceps maximal voluntary force (30.8 ± 10.4 and 36.4 ± 12.8 kg; P = 0.02), respectively. No significant effect of BK2R genotype on inspiratory muscle strength or on any variable in control subjects was observed. There was no interaction between the effect of the BK2R and ACE genotypes on quadriceps strength. Conclusions:The genotype associated with reduced BK2R expression is associated with reduced fat-free mass and quadriceps strength in COPD. However, alterations in the activity at the BK2R do not seem to account for the previously identified association of quadriceps strength with ACE genotype." @default.
• W1853905915 created "2016-06-24" @default.
• W1853905915 creator A5000748546 @default.
• W1853905915 creator A5004128310 @default.
• W1853905915 creator A5014597065 @default.
• W1853905915 creator A5032803617 @default.
• W1853905915 creator A5075249941 @default.
• W1853905915 creator A5081483438 @default.
• W1853905915 creator A5086453071 @default.
• W1853905915 creator A5090845182 @default.
• W1853905915 date "2006-04-01" @default.
• W1853905915 modified "2023-09-25" @default.
• W1853905915 title "+9/+9 Homozygosity of the bradykinin receptor gene polymorphism is associated with reduced fat-free mass in chronic obstructive pulmonary disease" @default.
• W1853905915 cites W1528220495 @default.
• W1853905915 cites W1720411992 @default.
• W1853905915 cites W1905676640 @default.
• W1853905915 cites W1964132126 @default.
• W1853905915 cites W1966939913 @default.
• W1853905915 cites W1967486150 @default.
• W1853905915 cites W1967889368 @default.
• W1853905915 cites W1983618068 @default.
• W1853905915 cites W2000347127 @default.
• W1853905915 cites W2019823382 @default.
• W1853905915 cites W2020021584 @default.
• W1853905915 cites W2031588446 @default.
• W1853905915 cites W2040437662 @default.
• W1853905915 cites W2041792789 @default.
• W1853905915 cites W2046452967 @default.
• W1853905915 cites W2051839369 @default.
• W1853905915 cites W2062353585 @default.
• W1853905915 cites W2067637944 @default.
• W1853905915 cites W2074758016 @default.
• W1853905915 cites W2079195354 @default.
• W1853905915 cites W2079538435 @default.
• W1853905915 cites W2086033446 @default.
• W1853905915 cites W2097532633 @default.
• W1853905915 cites W2099061873 @default.
• W1853905915 cites W2100006057 @default.
• W1853905915 cites W2101253614 @default.
• W1853905915 cites W2103951118 @default.
• W1853905915 cites W2116784557 @default.
• W1853905915 cites W2120948451 @default.
• W1853905915 cites W2123813808 @default.
• W1853905915 cites W2134337836 @default.
• W1853905915 cites W2137187223 @default.
• W1853905915 cites W2154851491 @default.
• W1853905915 cites W2161359488 @default.
• W1853905915 cites W2164732757 @default.
• W1853905915 cites W2168366921 @default.
• W1853905915 cites W2280301353 @default.
• W1853905915 cites W2319237482 @default.
• W1853905915 cites W2416990511 @default.
• W1853905915 cites W2422475194 @default.
• W1853905915 cites W4211025614 @default.
• W1853905915 cites W4241143820 @default.
• W1853905915 cites W4323239224 @default.
• W1853905915 cites W48031782 @default.
• W1853905915 cites W50715829 @default.
• W1853905915 doi "https://doi.org/10.1093/ajcn/83.4.912" @default.
• W1853905915 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16600946" @default.
• W1853905915 hasPublicationYear "2006" @default.
• W1853905915 type Work @default.
• W1853905915 sameAs 1853905915 @default.
• W1853905915 citedByCount "33" @default.
• W1853905915 countsByYear W18539059152012 @default.
• W1853905915 countsByYear W18539059152013 @default.
• W1853905915 countsByYear W18539059152014 @default.
• W1853905915 countsByYear W18539059152016 @default.
• W1853905915 countsByYear W18539059152017 @default.
• W1853905915 countsByYear W18539059152018 @default.
• W1853905915 countsByYear W18539059152022 @default.
• W1853905915 countsByYear W18539059152023 @default.
• W1853905915 crossrefType "journal-article" @default.
• W1853905915 hasAuthorship W1853905915A5000748546 @default.
• W1853905915 hasAuthorship W1853905915A5004128310 @default.
• W1853905915 hasAuthorship W1853905915A5014597065 @default.
• W1853905915 hasAuthorship W1853905915A5032803617 @default.
• W1853905915 hasAuthorship W1853905915A5075249941 @default.
• W1853905915 hasAuthorship W1853905915A5081483438 @default.
• W1853905915 hasAuthorship W1853905915A5086453071 @default.
• W1853905915 hasAuthorship W1853905915A5090845182 @default.
• W1853905915 hasBestOaLocation W18539059151 @default.
• W1853905915 hasConcept C104317684 @default.
• W1853905915 hasConcept C126322002 @default.
• W1853905915 hasConcept C134018914 @default.
• W1853905915 hasConcept C135763542 @default.
• W1853905915 hasConcept C180754005 @default.
• W1853905915 hasConcept C27016395 @default.
• W1853905915 hasConcept C2776780178 @default.
• W1853905915 hasConcept C2780221984 @default.
• W1853905915 hasConcept C2908647359 @default.
• W1853905915 hasConcept C54355233 @default.
• W1853905915 hasConcept C71924100 @default.
• W1853905915 hasConcept C76252995 @default.
• W1853905915 hasConcept C84393581 @default.
• W1853905915 hasConcept C86803240 @default.
• W1853905915 hasConcept C90924648 @default.
• W1853905915 hasConcept C99454951 @default.

• next