FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W185401412> ?p ?o ?g. }

• W185401412 endingPage "168" @default.
• W185401412 startingPage "153" @default.
• W185401412 abstract "The blood brain barrier regulates the transport of chemicals from entering and leaving the brain. Brain capillaries establish the barrier and restrict transport into the brain by providing a physical and chemical barrier. The physical barrier is due to tight membrane junctions separating the capillary endothelial cells resulting in limited paracellular transport. The chemical barrier is due to the expression of multidrug transporters that mediate the efflux of a broad range of hydrophobic chemicals. Because of the unusual nutrient demands of the brain, this limited permeability is compensated by the expression of a large number of transporters that are responsive to the metabolic demands of the brain. Consequently, the blood brain barrier indirectly regulates brain function by directly controlling the uptake of nutrients. Two widely used methods for studying the blood brain are a cell culture model using rat, pig, or cow brain endothelial cells and isolated microvessels. The cell culture model is more popular likely because it is easier to use and less costly compared to isolated microvessels. In some laboratories, brain endothelial cells are cocultured with astrocyte- or astroglial-conditioned media. The endothelial cells express many of the transporters displayed in vivo but not all. Although cell culture models vary, none express the tight barrier observed in vivo. Because microvessels are isolated directly from the brain, they express all of the transporters displayed in vivo. Their disadvantage is that the preparation is laborious, requires animals, and has a shorter lifespan in vitro. We present an approach in which transport is first verified in isolated microvessels, and then the mechanism is studied in cell culture." @default.
• W185401412 created "2016-06-24" @default.
• W185401412 creator A5056746393 @default.
• W185401412 creator A5057450889 @default.
• W185401412 creator A5058445186 @default.
• W185401412 date "2011-01-01" @default.
• W185401412 modified "2023-09-23" @default.
• W185401412 title "In Vitro Models to Study the Blood Brain Barrier" @default.
• W185401412 cites W1924595537 @default.
• W185401412 cites W1961820026 @default.
• W185401412 cites W1972326404 @default.
• W185401412 cites W1972514732 @default.
• W185401412 cites W1982730947 @default.
• W185401412 cites W1987532040 @default.
• W185401412 cites W1989438185 @default.
• W185401412 cites W2000171395 @default.
• W185401412 cites W2001097099 @default.
• W185401412 cites W2005040135 @default.
• W185401412 cites W2005447528 @default.
• W185401412 cites W2013495726 @default.
• W185401412 cites W2030190365 @default.
• W185401412 cites W2032148908 @default.
• W185401412 cites W2040732222 @default.
• W185401412 cites W2045312970 @default.
• W185401412 cites W2048154576 @default.
• W185401412 cites W2055650738 @default.
• W185401412 cites W2066344875 @default.
• W185401412 cites W2066411956 @default.
• W185401412 cites W2067733328 @default.
• W185401412 cites W2069970283 @default.
• W185401412 cites W2070573684 @default.
• W185401412 cites W2079146778 @default.
• W185401412 cites W2081148102 @default.
• W185401412 cites W2085146964 @default.
• W185401412 cites W2100486119 @default.
• W185401412 cites W2101867068 @default.
• W185401412 cites W2106454660 @default.
• W185401412 cites W2118309500 @default.
• W185401412 cites W2159082878 @default.
• W185401412 cites W2173273229 @default.
• W185401412 cites W2402777741 @default.
• W185401412 cites W64354099 @default.
• W185401412 doi "https://doi.org/10.1007/978-1-61779-170-3_10" @default.
• W185401412 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21815064" @default.
• W185401412 hasPublicationYear "2011" @default.
• W185401412 type Work @default.
• W185401412 sameAs 185401412 @default.
• W185401412 citedByCount "19" @default.
• W185401412 countsByYear W1854014122013 @default.
• W185401412 countsByYear W1854014122014 @default.
• W185401412 countsByYear W1854014122015 @default.
• W185401412 countsByYear W1854014122016 @default.
• W185401412 countsByYear W1854014122019 @default.
• W185401412 countsByYear W1854014122021 @default.
• W185401412 countsByYear W1854014122022 @default.
• W185401412 countsByYear W1854014122023 @default.
• W185401412 crossrefType "book-chapter" @default.
• W185401412 hasAuthorship W185401412A5056746393 @default.
• W185401412 hasAuthorship W185401412A5057450889 @default.
• W185401412 hasAuthorship W185401412A5058445186 @default.
• W185401412 hasConcept C104317684 @default.
• W185401412 hasConcept C120882062 @default.
• W185401412 hasConcept C123012128 @default.
• W185401412 hasConcept C134728086 @default.
• W185401412 hasConcept C149011108 @default.
• W185401412 hasConcept C150903083 @default.
• W185401412 hasConcept C169760540 @default.
• W185401412 hasConcept C177779419 @default.
• W185401412 hasConcept C185592680 @default.
• W185401412 hasConcept C200082930 @default.
• W185401412 hasConcept C202751555 @default.
• W185401412 hasConcept C207001950 @default.
• W185401412 hasConcept C2777542381 @default.
• W185401412 hasConcept C2778402981 @default.
• W185401412 hasConcept C41625074 @default.
• W185401412 hasConcept C51911345 @default.
• W185401412 hasConcept C529278444 @default.
• W185401412 hasConcept C55493867 @default.
• W185401412 hasConcept C60903277 @default.
• W185401412 hasConcept C86803240 @default.
• W185401412 hasConcept C95444343 @default.
• W185401412 hasConceptScore W185401412C104317684 @default.
• W185401412 hasConceptScore W185401412C120882062 @default.
• W185401412 hasConceptScore W185401412C123012128 @default.
• W185401412 hasConceptScore W185401412C134728086 @default.
• W185401412 hasConceptScore W185401412C149011108 @default.
• W185401412 hasConceptScore W185401412C150903083 @default.
• W185401412 hasConceptScore W185401412C169760540 @default.
• W185401412 hasConceptScore W185401412C177779419 @default.
• W185401412 hasConceptScore W185401412C185592680 @default.
• W185401412 hasConceptScore W185401412C200082930 @default.
• W185401412 hasConceptScore W185401412C202751555 @default.
• W185401412 hasConceptScore W185401412C207001950 @default.
• W185401412 hasConceptScore W185401412C2777542381 @default.
• W185401412 hasConceptScore W185401412C2778402981 @default.
• W185401412 hasConceptScore W185401412C41625074 @default.
• W185401412 hasConceptScore W185401412C51911345 @default.
• W185401412 hasConceptScore W185401412C529278444 @default.

• next