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- W1854103749 endingPage "1368" @default.
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- W1854103749 abstract "We have shown previously that Wiskott-Aldrich syndrome protein (WASP) activation at the site of T cell-APC interaction is a two-step process, with recruitment dependent on the proline-rich domain and activation dependent on binding of Cdc42-GTP to the GTPase binding domain. Here, we show that WASP recruitment occurs through binding to the C-terminal Src homology 3 domain of Nck. In contrast, WASP activation requires Vav-1. In Vav-1-deficient T cells, WASP recruitment proceeds normally, but localized activation of Cdc42 and WASP is disrupted. The recruitment and activation of WASP are coordinated by tyrosine-phosphorylated Src homology 2 domain-containing leukocyte protein of 76 kDa, which functions as a scaffold, bringing Nck and WASP into proximity with Vav-1 and Cdc42-GTP. Taken together, these findings reconstruct the signaling pathway leading from TCR ligation to localized WASP activation." @default.
- W1854103749 created "2016-06-24" @default.
- W1854103749 creator A5005071379 @default.
- W1854103749 creator A5010336321 @default.
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- W1854103749 creator A5059818176 @default.
- W1854103749 creator A5080426319 @default.
- W1854103749 creator A5089184804 @default.
- W1854103749 date "2003-08-01" @default.
- W1854103749 modified "2023-09-27" @default.
- W1854103749 title "SLP-76 Coordinates Nck-Dependent Wiskott-Aldrich Syndrome Protein Recruitment with Vav-1/Cdc42-Dependent Wiskott-Aldrich Syndrome Protein Activation at the T Cell-APC Contact Site" @default.
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- W1854103749 doi "https://doi.org/10.4049/jimmunol.171.3.1360" @default.
- W1854103749 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12874226" @default.
- W1854103749 hasPublicationYear "2003" @default.
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