Matches in SemOpenAlex for { <https://semopenalex.org/work/W1854126421> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W1854126421 endingPage "51" @default.
- W1854126421 startingPage "46" @default.
- W1854126421 abstract "Human lymphoblastoid interferon-alpha was administered intramuscularly at a dose of 5 x 10(6) units/day to 20 metastatic renal cell carcinoma patients. For potentiating the antitumor effect of interferon, cimetidine was also given to them orally at a dose of 800 mg/day. The combination therapy obtained a complete response in three patients (15%) and a partial response in three (15%). Nine patients (45%) had stable disease and five (25%), progressive disease. All six patients who responded to the combination therapy had been nephrectomized and had pulmonary metastases. Two of them also had metastases to other sites (mediastinal lymph nodes and bone). The pulmonary metastases were significantly more receptive to interferon therapy than those at the other sites. The average times before a response was obtained were 2.2 months for a minor response, 2.7 months for a partial response and 3.0 months for a complete response, and the average duration of response was 26 months. The six patients who responded survived for a significantly longer period than the 14 non-responding patients treated with interferon in combination with cimetidine. The major toxicities encountered were fever, fatigue and anorexia due to interferon, and the combination therapy was well tolerated except in three patients. The results suggest that interferon-alpha and cimetidine combination therapy may be of use in the management of patients with metastatic renal cell carcinoma." @default.
- W1854126421 created "2016-06-24" @default.
- W1854126421 creator A5017120161 @default.
- W1854126421 creator A5020661488 @default.
- W1854126421 creator A5043265594 @default.
- W1854126421 creator A5054076544 @default.
- W1854126421 creator A5069560139 @default.
- W1854126421 creator A5075504858 @default.
- W1854126421 creator A5087645106 @default.
- W1854126421 date "1991-02-01" @default.
- W1854126421 modified "2023-09-27" @default.
- W1854126421 title "Treatment of metastatic renal cell carcinoma with a combination of human lymphoblastoid interferon-alpha and cimetidine." @default.
- W1854126421 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2067120" @default.
- W1854126421 hasPublicationYear "1991" @default.
- W1854126421 type Work @default.
- W1854126421 sameAs 1854126421 @default.
- W1854126421 citedByCount "1" @default.
- W1854126421 crossrefType "journal-article" @default.
- W1854126421 hasAuthorship W1854126421A5017120161 @default.
- W1854126421 hasAuthorship W1854126421A5020661488 @default.
- W1854126421 hasAuthorship W1854126421A5043265594 @default.
- W1854126421 hasAuthorship W1854126421A5054076544 @default.
- W1854126421 hasAuthorship W1854126421A5069560139 @default.
- W1854126421 hasAuthorship W1854126421A5075504858 @default.
- W1854126421 hasAuthorship W1854126421A5087645106 @default.
- W1854126421 hasConcept C126322002 @default.
- W1854126421 hasConcept C142724271 @default.
- W1854126421 hasConcept C143998085 @default.
- W1854126421 hasConcept C203014093 @default.
- W1854126421 hasConcept C2776178377 @default.
- W1854126421 hasConcept C2776694085 @default.
- W1854126421 hasConcept C2776999253 @default.
- W1854126421 hasConcept C2777472916 @default.
- W1854126421 hasConcept C2777546739 @default.
- W1854126421 hasConcept C2778822529 @default.
- W1854126421 hasConcept C2779720271 @default.
- W1854126421 hasConcept C2780719153 @default.
- W1854126421 hasConcept C2781228144 @default.
- W1854126421 hasConcept C2909179924 @default.
- W1854126421 hasConcept C71924100 @default.
- W1854126421 hasConcept C90924648 @default.
- W1854126421 hasConceptScore W1854126421C126322002 @default.
- W1854126421 hasConceptScore W1854126421C142724271 @default.
- W1854126421 hasConceptScore W1854126421C143998085 @default.
- W1854126421 hasConceptScore W1854126421C203014093 @default.
- W1854126421 hasConceptScore W1854126421C2776178377 @default.
- W1854126421 hasConceptScore W1854126421C2776694085 @default.
- W1854126421 hasConceptScore W1854126421C2776999253 @default.
- W1854126421 hasConceptScore W1854126421C2777472916 @default.
- W1854126421 hasConceptScore W1854126421C2777546739 @default.
- W1854126421 hasConceptScore W1854126421C2778822529 @default.
- W1854126421 hasConceptScore W1854126421C2779720271 @default.
- W1854126421 hasConceptScore W1854126421C2780719153 @default.
- W1854126421 hasConceptScore W1854126421C2781228144 @default.
- W1854126421 hasConceptScore W1854126421C2909179924 @default.
- W1854126421 hasConceptScore W1854126421C71924100 @default.
- W1854126421 hasConceptScore W1854126421C90924648 @default.
- W1854126421 hasIssue "1" @default.
- W1854126421 hasLocation W18541264211 @default.
- W1854126421 hasOpenAccess W1854126421 @default.
- W1854126421 hasPrimaryLocation W18541264211 @default.
- W1854126421 hasRelatedWork W158907189 @default.
- W1854126421 hasRelatedWork W1595172314 @default.
- W1854126421 hasRelatedWork W1854126421 @default.
- W1854126421 hasRelatedWork W1996352524 @default.
- W1854126421 hasRelatedWork W2020081463 @default.
- W1854126421 hasRelatedWork W2052392525 @default.
- W1854126421 hasRelatedWork W2226617841 @default.
- W1854126421 hasRelatedWork W2316507190 @default.
- W1854126421 hasRelatedWork W2414867669 @default.
- W1854126421 hasRelatedWork W4242253897 @default.
- W1854126421 hasVolume "21" @default.
- W1854126421 isParatext "false" @default.
- W1854126421 isRetracted "false" @default.
- W1854126421 magId "1854126421" @default.
- W1854126421 workType "article" @default.