Matches in SemOpenAlex for { <https://semopenalex.org/work/W1854281301> ?p ?o ?g. }
- W1854281301 endingPage "219" @default.
- W1854281301 startingPage "208" @default.
- W1854281301 abstract "Eukaryotic cells possess numerous dynamic membrane-less organelles, RNP granules, enriched in RNA and RNA-binding proteins containing disordered regions. We demonstrate that the disordered regions of key RNP granule components and the full-length granule protein hnRNPA1 can phase separate in vitro, producing dynamic liquid droplets. Phase separation is promoted by low salt concentrations or RNA. Over time, the droplets mature to more stable states, as assessed by slowed fluorescence recovery after photobleaching and resistance to salt. Maturation often coincides with formation of fibrous structures. Different disordered domains can co-assemble into phase-separated droplets. These biophysical properties demonstrate a plausible mechanism by which interactions between disordered regions, coupled with RNA binding, could contribute to RNP granule assembly in vivo through promoting phase separation. Progression from dynamic liquids to stable fibers may be regulated to produce cellular structures with diverse physiochemical properties and functions. Misregulation could contribute to diseases involving aberrant RNA granules." @default.
- W1854281301 created "2016-06-24" @default.
- W1854281301 creator A5012173770 @default.
- W1854281301 creator A5014796446 @default.
- W1854281301 creator A5022809268 @default.
- W1854281301 creator A5047439275 @default.
- W1854281301 date "2015-10-01" @default.
- W1854281301 modified "2023-10-14" @default.
- W1854281301 title "Formation and Maturation of Phase-Separated Liquid Droplets by RNA-Binding Proteins" @default.
- W1854281301 cites W1965286266 @default.
- W1854281301 cites W1977504104 @default.
- W1854281301 cites W1978942137 @default.
- W1854281301 cites W1980031483 @default.
- W1854281301 cites W1993084790 @default.
- W1854281301 cites W1997342202 @default.
- W1854281301 cites W2018044240 @default.
- W1854281301 cites W2026226960 @default.
- W1854281301 cites W2039914635 @default.
- W1854281301 cites W2044821390 @default.
- W1854281301 cites W2054352933 @default.
- W1854281301 cites W2064367582 @default.
- W1854281301 cites W2064386997 @default.
- W1854281301 cites W2065139981 @default.
- W1854281301 cites W2066107559 @default.
- W1854281301 cites W2067342057 @default.
- W1854281301 cites W2074247664 @default.
- W1854281301 cites W2075425743 @default.
- W1854281301 cites W2078319586 @default.
- W1854281301 cites W2079470515 @default.
- W1854281301 cites W2085978470 @default.
- W1854281301 cites W2097843267 @default.
- W1854281301 cites W2104873074 @default.
- W1854281301 cites W2105945357 @default.
- W1854281301 cites W2110739636 @default.
- W1854281301 cites W2111796925 @default.
- W1854281301 cites W2114717251 @default.
- W1854281301 cites W2116592258 @default.
- W1854281301 cites W2118659843 @default.
- W1854281301 cites W2119651404 @default.
- W1854281301 cites W2120156669 @default.
- W1854281301 cites W2123659736 @default.
- W1854281301 cites W2125272201 @default.
- W1854281301 cites W2130350273 @default.
- W1854281301 cites W2132121416 @default.
- W1854281301 cites W2146865209 @default.
- W1854281301 cites W2147257738 @default.
- W1854281301 cites W2149541702 @default.
- W1854281301 cites W2150860983 @default.
- W1854281301 cites W2152675476 @default.
- W1854281301 cites W2159354359 @default.
- W1854281301 cites W2165962849 @default.
- W1854281301 cites W2168639701 @default.
- W1854281301 cites W2171714127 @default.
- W1854281301 cites W2172098255 @default.
- W1854281301 doi "https://doi.org/10.1016/j.molcel.2015.08.018" @default.
- W1854281301 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4609299" @default.
- W1854281301 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26412307" @default.
- W1854281301 hasPublicationYear "2015" @default.
- W1854281301 type Work @default.
- W1854281301 sameAs 1854281301 @default.
- W1854281301 citedByCount "1232" @default.
- W1854281301 countsByYear W18542813012015 @default.
- W1854281301 countsByYear W18542813012016 @default.
- W1854281301 countsByYear W18542813012017 @default.
- W1854281301 countsByYear W18542813012018 @default.
- W1854281301 countsByYear W18542813012019 @default.
- W1854281301 countsByYear W18542813012020 @default.
- W1854281301 countsByYear W18542813012021 @default.
- W1854281301 countsByYear W18542813012022 @default.
- W1854281301 countsByYear W18542813012023 @default.
- W1854281301 crossrefType "journal-article" @default.
- W1854281301 hasAuthorship W1854281301A5012173770 @default.
- W1854281301 hasAuthorship W1854281301A5014796446 @default.
- W1854281301 hasAuthorship W1854281301A5022809268 @default.
- W1854281301 hasAuthorship W1854281301A5047439275 @default.
- W1854281301 hasBestOaLocation W18542813011 @default.
- W1854281301 hasConcept C104317684 @default.
- W1854281301 hasConcept C105580179 @default.
- W1854281301 hasConcept C117838200 @default.
- W1854281301 hasConcept C12554922 @default.
- W1854281301 hasConcept C149364088 @default.
- W1854281301 hasConcept C151730666 @default.
- W1854281301 hasConcept C168240541 @default.
- W1854281301 hasConcept C26659971 @default.
- W1854281301 hasConcept C2991743866 @default.
- W1854281301 hasConcept C41282012 @default.
- W1854281301 hasConcept C41625074 @default.
- W1854281301 hasConcept C49760210 @default.
- W1854281301 hasConcept C55493867 @default.
- W1854281301 hasConcept C67705224 @default.
- W1854281301 hasConcept C86803240 @default.
- W1854281301 hasConcept C95444343 @default.
- W1854281301 hasConceptScore W1854281301C104317684 @default.
- W1854281301 hasConceptScore W1854281301C105580179 @default.
- W1854281301 hasConceptScore W1854281301C117838200 @default.
- W1854281301 hasConceptScore W1854281301C12554922 @default.
- W1854281301 hasConceptScore W1854281301C149364088 @default.
- W1854281301 hasConceptScore W1854281301C151730666 @default.