FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W185436991> ?p ?o ?g. }

• W185436991 endingPage "4643" @default.
• W185436991 startingPage "4634" @default.
• W185436991 abstract "The use of medicinal plants has gained much attention in the last decade, and among those plants commonly used as medication in folk medicine, various extracts have been the subject of many pharmacological studies. Pomegranate (Punica granatum) a fruit with rich ethnomedical applications, has been also introduced as potential anti-microbial and anti-helminthic agent. This study was designed to estimate its in vivo and in vitro effects on S. mansoni. The in vitro bioassay of Punica granatum, (P. granatum) peels and leaves extracts was carried out using ascending doses. V iability of worms and schistosomules was examined using negative (DMSO) and positive (PZQ) controls. This study revealed that P. granatum had significant effect on both adult S. mansoni worms and schistosomules reaching 100% death rate, 24 hours post exposure to extracted plant. Concerning the in vivo activity, P. granatum peels and leaves exhibited antischistosomal properties by the oral administration of either extract, in a dose of 800mg/kg, 45 days post-infection and on 3 consecutive days; this dose was given following a pilot study to evaluate the highest safe dose. Parasitological parameters showed remarkable decrease manifested by high percentage of dead adult worm (77.30 and 72.2) with either leaves or peels extract respectively. The tissue egg load also revealed marked reduction in both liver and intestinal ova counts. The percentage reduction of adult worms reached (90.9 and 55.4) with extracted leaves or peels respectively, when P.granatum extracts were given 21 days post-infection using the same dose(800mg/kg),denoting a high significant effect of leaves extracts on schistosomule s.Electron microscopic examination of perfused adult worms, confirmed the parasitological results and revealed the effect of the methanolic extracts of P.granatum in inducing major ultrastructural alterations in the tegument and the male genital systems of the worms that lead to their death. In this study EM examination of bone marrow taken from S. mansoni infected mice, treated with either leaves or peels extracts of P.granatum showed complete degranulation of eosinophils and activated lymphocytes with extended projections and increased mitochondria in addition to activated monoblast with increased number of phagolysosomes.Since secretions of the different stages of S.mansoni have inhibitory effect on eosinophilic degranulation and monoblasts, as part of their parasite evasion mechanism, the apparent degranulation would indicate the decreased activity of S.mansoni. The leaves and peels extracts of Punica granatum could represent promising bioactive natural agents that deserve further investigation, with the aim of introducing novel anti-schistosomal agent." @default.
• W185436991 created "2016-06-24" @default.
• W185436991 creator A5005725948 @default.
• W185436991 creator A5008698250 @default.
• W185436991 creator A5013460732 @default.
• W185436991 creator A5059216283 @default.
• W185436991 creator A5059708249 @default.
• W185436991 date "2009-01-01" @default.
• W185436991 modified "2023-10-13" @default.
• W185436991 title "Potential antiparasitic activity of pomegranate extracts against schistosomules and mature worms of Schistosoma mansoni: in vitro and in vivo study." @default.
• W185436991 cites W1277803216 @default.
• W185436991 cites W1533499877 @default.
• W185436991 cites W1969589255 @default.
• W185436991 cites W1970326538 @default.
• W185436991 cites W1983156875 @default.
• W185436991 cites W1999999237 @default.
• W185436991 cites W2009971590 @default.
• W185436991 cites W2011587893 @default.
• W185436991 cites W2012733107 @default.
• W185436991 cites W2024494920 @default.
• W185436991 cites W2033312013 @default.
• W185436991 cites W2037246614 @default.
• W185436991 cites W2077029079 @default.
• W185436991 cites W2078293974 @default.
• W185436991 cites W2084780129 @default.
• W185436991 cites W2087849947 @default.
• W185436991 cites W2092070906 @default.
• W185436991 cites W2093471180 @default.
• W185436991 cites W2094870284 @default.
• W185436991 cites W2158236821 @default.
• W185436991 cites W2164016288 @default.
• W185436991 cites W2397518918 @default.
• W185436991 cites W2398645101 @default.
• W185436991 cites W2610733940 @default.
• W185436991 cites W312292187 @default.
• W185436991 cites W81863124 @default.
• W185436991 cites W94226324 @default.
• W185436991 cites W1481220911 @default.
• W185436991 hasPublicationYear "2009" @default.
• W185436991 type Work @default.
• W185436991 sameAs 185436991 @default.
• W185436991 citedByCount "2" @default.
• W185436991 countsByYear W1854369912013 @default.
• W185436991 countsByYear W1854369912018 @default.
• W185436991 crossrefType "journal-article" @default.
• W185436991 hasAuthorship W185436991A5005725948 @default.
• W185436991 hasAuthorship W185436991A5008698250 @default.
• W185436991 hasAuthorship W185436991A5013460732 @default.
• W185436991 hasAuthorship W185436991A5059216283 @default.
• W185436991 hasAuthorship W185436991A5059708249 @default.
• W185436991 hasConcept C142724271 @default.
• W185436991 hasConcept C150903083 @default.
• W185436991 hasConcept C165901193 @default.
• W185436991 hasConcept C202751555 @default.
• W185436991 hasConcept C203014093 @default.
• W185436991 hasConcept C207001950 @default.
• W185436991 hasConcept C2776225656 @default.
• W185436991 hasConcept C2776863245 @default.
• W185436991 hasConcept C2779158651 @default.
• W185436991 hasConcept C2780125355 @default.
• W185436991 hasConcept C2781421772 @default.
• W185436991 hasConcept C33070731 @default.
• W185436991 hasConcept C55493867 @default.
• W185436991 hasConcept C556039675 @default.
• W185436991 hasConcept C71924100 @default.
• W185436991 hasConcept C86803240 @default.
• W185436991 hasConceptScore W185436991C142724271 @default.
• W185436991 hasConceptScore W185436991C150903083 @default.
• W185436991 hasConceptScore W185436991C165901193 @default.
• W185436991 hasConceptScore W185436991C202751555 @default.
• W185436991 hasConceptScore W185436991C203014093 @default.
• W185436991 hasConceptScore W185436991C207001950 @default.
• W185436991 hasConceptScore W185436991C2776225656 @default.
• W185436991 hasConceptScore W185436991C2776863245 @default.
• W185436991 hasConceptScore W185436991C2779158651 @default.
• W185436991 hasConceptScore W185436991C2780125355 @default.
• W185436991 hasConceptScore W185436991C2781421772 @default.
• W185436991 hasConceptScore W185436991C33070731 @default.
• W185436991 hasConceptScore W185436991C55493867 @default.
• W185436991 hasConceptScore W185436991C556039675 @default.
• W185436991 hasConceptScore W185436991C71924100 @default.
• W185436991 hasConceptScore W185436991C86803240 @default.
• W185436991 hasIssue "4" @default.
• W185436991 hasLocation W1854369911 @default.
• W185436991 hasOpenAccess W185436991 @default.
• W185436991 hasPrimaryLocation W1854369911 @default.
• W185436991 hasRelatedWork W1483879387 @default.
• W185436991 hasRelatedWork W1825304268 @default.
• W185436991 hasRelatedWork W1967372985 @default.
• W185436991 hasRelatedWork W2126360340 @default.
• W185436991 hasRelatedWork W2164256152 @default.
• W185436991 hasRelatedWork W2165978377 @default.
• W185436991 hasRelatedWork W2169237236 @default.
• W185436991 hasRelatedWork W2565707564 @default.
• W185436991 hasRelatedWork W2592007528 @default.
• W185436991 hasRelatedWork W2603411290 @default.
• W185436991 hasRelatedWork W2624311104 @default.
• W185436991 hasRelatedWork W2766389483 @default.

• next