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- W185447484 abstract "Bradykinin (BK) and Lys-BK are vasoactive peptides generated via the cleavage of kininogen by the action of kallikrein proteases. Both have a half-life of only seconds within the circulation, being rapidly hydrolyzed to biologically active des-Arg kinin derivatives. BK and Lys-BK cause the classical signs of inflammation – redness, local heat, swelling, and pain – whereas their des-Arg derivatives induce increased collagen synthesis, fibroblast proliferation, and cytokine release from macrophages. The effects of these peptides are mediated by two distinct G-coupled receptors. The kinin system has been implicated in the pathophysiology of human airway inflammation. Inhalation of BK by asthmatics results in chest tightness, cough, and bronchoconstriction. Furthermore, increased levels of BK and Lys-BK, their derivatives, and tissue kallikrein are observed within the human airway following allergen provocation, with levels of BK correlating with symptom severity. Respiratory viral infections are also associated with increase levels of BK and Lys-BK within the airway. Research has demonstrated that BK is intricately involved in the pathogenesis of allergic airway inflammation and respiratory viral infections; as such, therapeutic methods for intervening in the activation of the kinin system may alleviate airway inflammation and symptoms of respiratory infections." @default.
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- W185447484 date "2006-01-01" @default.
- W185447484 modified "2023-10-16" @default.
- W185447484 title "KININS AND NEUROPEPTIDES | Bradykinin" @default.
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- W185447484 doi "https://doi.org/10.1016/b0-12-370879-6/00209-x" @default.
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