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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1854562809> ?p ?o ?g. }

• W1854562809 endingPage "8629" @default.
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• W1854562809 abstract "Transforming growth factor beta (TGF-beta) is a family of proteins secreted by virtually all cells in a biologically inactive form. TGF-beta levels increase during many pathophysiological situations, including viral infection. The mechanism for increased TGF-beta activity during viral infection is not understood. We observed an increase in active TGF-beta levels within 1 day in mice infected with influenza virus. Further studies showed that the neuraminidase glycoprotein of influenza A and B viruses directly activates latent TGF-beta in vitro. There are sufficient levels of TGF-beta activated by virus to induce apoptosis in cells. In addition, influenza virus-induced apoptosis is partially inhibited by TGF-beta-specific antibodies. These novel findings suggest a potential role for activation of TGF-beta during the host response to influenza virus infection, specifically apoptosis. This is the first report showing direct activation of latent TGF-beta by a viral protein." @default.
• W1854562809 created "2016-06-24" @default.
• W1854562809 creator A5057988545 @default.
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• W1854562809 date "1996-12-01" @default.
• W1854562809 modified "2023-10-15" @default.
• W1854562809 title "Influenza virus neuraminidase activates latent transforming growth factor beta" @default.
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• W1854562809 doi "https://doi.org/10.1128/jvi.70.12.8624-8629.1996" @default.
• W1854562809 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/190955" @default.
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