Matches in SemOpenAlex for { <https://semopenalex.org/work/W1854803455> ?p ?o ?g. }
- W1854803455 endingPage "165" @default.
- W1854803455 startingPage "115" @default.
- W1854803455 abstract "Publisher Summary The family of fibroblast growth factors (FGF) is the largest family of growth factors involved in soft–tissue growth and regeneration. The FGF family includes seven members that share a varying degree of homology at the protein level and appear to have a similar broad mitogenic spectrum. They are angiogenic and promote the proliferation of a variety of cells of mesodermal and neuroectodermal origin . Three members of the family–namely, K–FGF/HST, FGF–5, INT–2 are identified originally as oncogenes, while two additions, FGF–6 and keratinocyte growth factor (KGF), are isolated by sequence homology or factor purification and cloning. FGF was identified as an activity in pituitary extracts that stimulated the proliferation of 3T3 cells in mice. The two prototypes of basic and acidic protein structure, the FGF genes, and the expressions of FGF are also discussed. FGF consist of three exons, separated by two introns of variable length and FGF genes map on several chromosomes. The molecular regulation of FGF expression, FGF receptors, and their interaction with extracellular matrix is described. The oncogenic potential of FGF members and their involvement in tumors is also discussed. All possible mechanisms operating on the expression of FGFs and their receptors: transcriptional controls, posttranscriptional regulation involving alternative splicing, alternative translation starts resulting in proteins with different properties, and control affecting the secretion of these proteins are discussed." @default.
- W1854803455 created "2016-06-24" @default.
- W1854803455 creator A5012405901 @default.
- W1854803455 creator A5091002644 @default.
- W1854803455 date "1992-01-01" @default.
- W1854803455 modified "2023-10-10" @default.
- W1854803455 title "The Fgf Family of Growth Factors and Oncogenes" @default.
- W1854803455 cites W105106768 @default.
- W1854803455 cites W1208024610 @default.
- W1854803455 cites W1483159812 @default.
- W1854803455 cites W1490516771 @default.
- W1854803455 cites W1494345685 @default.
- W1854803455 cites W1494803482 @default.
- W1854803455 cites W1495121347 @default.
- W1854803455 cites W1502488284 @default.
- W1854803455 cites W1509771261 @default.
- W1854803455 cites W1515556443 @default.
- W1854803455 cites W1531144136 @default.
- W1854803455 cites W1558381483 @default.
- W1854803455 cites W1587480418 @default.
- W1854803455 cites W1655632696 @default.
- W1854803455 cites W1672700608 @default.
- W1854803455 cites W1686153396 @default.
- W1854803455 cites W1780824832 @default.
- W1854803455 cites W1784257340 @default.
- W1854803455 cites W1796421249 @default.
- W1854803455 cites W1813092835 @default.
- W1854803455 cites W1860007525 @default.
- W1854803455 cites W1862567903 @default.
- W1854803455 cites W1871141908 @default.
- W1854803455 cites W1881900550 @default.
- W1854803455 cites W1889979414 @default.
- W1854803455 cites W1890507836 @default.
- W1854803455 cites W1892096673 @default.
- W1854803455 cites W1928956084 @default.
- W1854803455 cites W1942708553 @default.
- W1854803455 cites W1948307417 @default.
- W1854803455 cites W1964629878 @default.
- W1854803455 cites W1965918354 @default.
- W1854803455 cites W1966182982 @default.
- W1854803455 cites W1966600531 @default.
- W1854803455 cites W1967851651 @default.
- W1854803455 cites W1972855766 @default.
- W1854803455 cites W1973525462 @default.
- W1854803455 cites W1973700121 @default.
- W1854803455 cites W1974450466 @default.
- W1854803455 cites W1974873948 @default.
- W1854803455 cites W1975369919 @default.
- W1854803455 cites W1975519085 @default.
- W1854803455 cites W1975749015 @default.
- W1854803455 cites W1975991554 @default.
- W1854803455 cites W1976846847 @default.
- W1854803455 cites W1977311938 @default.
- W1854803455 cites W1978094951 @default.
- W1854803455 cites W1978313777 @default.
- W1854803455 cites W1978411854 @default.
- W1854803455 cites W1979403186 @default.
- W1854803455 cites W1981517866 @default.
- W1854803455 cites W1981958871 @default.
- W1854803455 cites W1982035434 @default.
- W1854803455 cites W1984648137 @default.
- W1854803455 cites W1985035051 @default.
- W1854803455 cites W1985401404 @default.
- W1854803455 cites W1985457327 @default.
- W1854803455 cites W1985979929 @default.
- W1854803455 cites W1986491860 @default.
- W1854803455 cites W1987092452 @default.
- W1854803455 cites W1988188677 @default.
- W1854803455 cites W1991957995 @default.
- W1854803455 cites W1992327323 @default.
- W1854803455 cites W1992486637 @default.
- W1854803455 cites W1993790237 @default.
- W1854803455 cites W1995453479 @default.
- W1854803455 cites W1996294835 @default.
- W1854803455 cites W1997135548 @default.
- W1854803455 cites W1998131878 @default.
- W1854803455 cites W1998338586 @default.
- W1854803455 cites W1999487908 @default.
- W1854803455 cites W1999521250 @default.
- W1854803455 cites W2002555237 @default.
- W1854803455 cites W2005200443 @default.
- W1854803455 cites W2005504315 @default.
- W1854803455 cites W2005665440 @default.
- W1854803455 cites W2005677919 @default.
- W1854803455 cites W2006641366 @default.
- W1854803455 cites W2006858340 @default.
- W1854803455 cites W2006874202 @default.
- W1854803455 cites W2007381150 @default.
- W1854803455 cites W2008808264 @default.
- W1854803455 cites W2008922304 @default.
- W1854803455 cites W2008980811 @default.
- W1854803455 cites W2010531937 @default.
- W1854803455 cites W2011403484 @default.
- W1854803455 cites W2013601551 @default.
- W1854803455 cites W2013634513 @default.
- W1854803455 cites W2013817382 @default.
- W1854803455 cites W2015611602 @default.
- W1854803455 cites W2017501645 @default.