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• W1854886985 abstract "The extracellular matrix of tissues is governed and maintained by cellsand a number of associated proteins. The extracellular matrix of theskeleton is highly specialized, in that it is mineralized and containsmatrix-specific proteins with unique functions. Recent advances inmineralized tissue research have identified novel functions for theextracellular matrix molecules; from mere structural components toregulators of tissue maintenance and endocrine homeostasis. Osteoblastsand odontoblasts, the mineral matrix-forming cells of the skeleton andteeth, differentiate from mesenchyme progenitors. In signaling ofdifferentiation into mature cells, the main switch towards osteoblast andodontoblast differentiation and bone formation is achieved by thesignaling of bone morphogenetic proteins. Inhibitory or stimulatorysignaling by several factors result in the expression of proteins andfactors which are necessary for the progression towards the maturecellular phenotype. Mature mineralized tissue producing cells secrete thecollagen matrix which later becomes mineralized by hydroxyapatite. Inaddition, these cells also secrete the non-collagenous proteins of themineralized tissue matrix that become incorporated into the matrix. Thefunction of many of these proteins has been studied extensively and anunderstanding of their effect on matrix and cellular maintenance is nowemerging.Two proteins that are produced and secreted by osteoblasts and/orodontoblasts were investigated within the scope for this thesis:osteoadherin and ADAMTS-1. With an emphasis on regulation and function,it was possible to determine that osteoadherin is upregulated byterminally differentiated osteoblast and that osteoadherin affectscellular migration, proliferation and differentiation. The regulation ofosteoadherin by neurotrophins in both osteoblasts and dental pulp cellssuggests that a complex signaling network occurs during the developmentof tissue maturation. ADAMTS-1 is a multifunctional enzyme withdisintegrin, thrombospondin and metalloproteinase domains. It wasdetermined that ADAMTS-1 is upregulated by parathyroid hormone andassociates with collagen and degrades it, and further that thecatalytically active enzyme promotes cellular colonization of the 3Denvironment.In summary, the work presented in this thesis provides novelunderstandings for the role of extracellular matrix proteins indetermining the behavior of mineralized tissue cells." @default.
• W1854886985 created "2016-06-24" @default.
• W1854886985 creator A5014293824 @default.
• W1854886985 date "2008-05-14" @default.
• W1854886985 modified "2023-09-24" @default.
• W1854886985 title "Regulation and function of mineralized tissue extra-cellular matrix proteins : Studies of ADAMTS-1 and osteoadherin" @default.
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