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- W1854932156 endingPage "20" @default.
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- W1854932156 abstract "Attempts continue to separate the components of the benzodiazepines' (BZs) profile as an approach to more selective drugs. Although the BZ receptor remains a reliable target for anxiolytic drug intervention, concerns over the side effects and dependence liability have spurred new research into alternate mechanisms of anxiolysis. A substantial effort is now involved in this serotonergic approach to novel anxiolytics. There is a wide spectrum of pharmacological profiles theoretically available from BZ receptor ligands, ranging from inverse agonists with anxiogenic potential, through “neutral” antagonists, to full agonists with classical anxiolytic activity. It is anticipated that partial agonists or mixed agonists/antagonists would produce anxiolytic effects without sedation or ataxia, regardless of the dose. Antagonist activity is usually evaluated in terms of blockade of one or more of the behavioral deficits induced by BZs, using a battery of neuropharmacological tests. For example, Ro 23-0364 is a minimally sedative agonist/antagonist, but it shows decreased symptoms of anxiety and some sedation at higher doses. Although a clinical comparison of the agonist/antagonist Ro 17-1812 and diazepam showed comparable behavioral properties for both compounds, pharmaco-EEG studies indicated that the former may possess a lower dependency risk than the latter. Research continues to produce anxiolytic agents that lack the profound central nervous system (CNS) depressant properties and other side effects of the classical BZs." @default.
- W1854932156 created "2016-06-24" @default.
- W1854932156 creator A5010573447 @default.
- W1854932156 creator A5033576342 @default.
- W1854932156 creator A5047795571 @default.
- W1854932156 date "1987-01-01" @default.
- W1854932156 modified "2023-09-24" @default.
- W1854932156 title "Chapter 2 Anxiolytics and Sedative-Hypnotics" @default.
- W1854932156 cites W1129501513 @default.
- W1854932156 cites W142315095 @default.
- W1854932156 cites W1635203761 @default.
- W1854932156 cites W1640209568 @default.
- W1854932156 cites W1898404641 @default.
- W1854932156 cites W1936257135 @default.
- W1854932156 cites W1964102853 @default.
- W1854932156 cites W1966837740 @default.
- W1854932156 cites W1966939865 @default.
- W1854932156 cites W1968633470 @default.
- W1854932156 cites W1969178676 @default.
- W1854932156 cites W1973397552 @default.
- W1854932156 cites W1974147974 @default.
- W1854932156 cites W1975044780 @default.
- W1854932156 cites W1980938363 @default.
- W1854932156 cites W1981455037 @default.
- W1854932156 cites W1984470666 @default.
- W1854932156 cites W1990283173 @default.
- W1854932156 cites W1991333174 @default.
- W1854932156 cites W1991398637 @default.
- W1854932156 cites W1993404256 @default.
- W1854932156 cites W1996278546 @default.
- W1854932156 cites W1998519813 @default.
- W1854932156 cites W1999327379 @default.
- W1854932156 cites W2001989400 @default.
- W1854932156 cites W2003063242 @default.
- W1854932156 cites W2003205209 @default.
- W1854932156 cites W2005395166 @default.
- W1854932156 cites W2006068256 @default.
- W1854932156 cites W2006638716 @default.
- W1854932156 cites W2006919635 @default.
- W1854932156 cites W2008555422 @default.
- W1854932156 cites W2010564989 @default.
- W1854932156 cites W2013857243 @default.
- W1854932156 cites W2014180323 @default.
- W1854932156 cites W2016800632 @default.
- W1854932156 cites W2018542757 @default.
- W1854932156 cites W2019801004 @default.
- W1854932156 cites W2022276674 @default.
- W1854932156 cites W2024561498 @default.
- W1854932156 cites W2025353116 @default.
- W1854932156 cites W2026820393 @default.
- W1854932156 cites W2028650350 @default.
- W1854932156 cites W2028857447 @default.
- W1854932156 cites W2031617382 @default.
- W1854932156 cites W2032312348 @default.
- W1854932156 cites W2033829608 @default.
- W1854932156 cites W2034687032 @default.
- W1854932156 cites W2037648719 @default.
- W1854932156 cites W2038086846 @default.
- W1854932156 cites W2038166177 @default.
- W1854932156 cites W2038478604 @default.
- W1854932156 cites W2038582232 @default.
- W1854932156 cites W2043750066 @default.
- W1854932156 cites W2043788707 @default.
- W1854932156 cites W2044137171 @default.
- W1854932156 cites W2046994328 @default.
- W1854932156 cites W2048868874 @default.
- W1854932156 cites W2050288581 @default.
- W1854932156 cites W2054676102 @default.
- W1854932156 cites W2056658916 @default.
- W1854932156 cites W2057561126 @default.
- W1854932156 cites W2058924283 @default.
- W1854932156 cites W2060139211 @default.
- W1854932156 cites W2060336422 @default.
- W1854932156 cites W2063982354 @default.
- W1854932156 cites W2064200202 @default.
- W1854932156 cites W2069889273 @default.
- W1854932156 cites W2070104718 @default.
- W1854932156 cites W2071805163 @default.
- W1854932156 cites W2077536772 @default.
- W1854932156 cites W2078012048 @default.
- W1854932156 cites W2081047826 @default.
- W1854932156 cites W2081594365 @default.
- W1854932156 cites W2082523284 @default.
- W1854932156 cites W2086062113 @default.
- W1854932156 cites W2087368964 @default.
- W1854932156 cites W2087565057 @default.
- W1854932156 cites W2088157696 @default.
- W1854932156 cites W2093374164 @default.
- W1854932156 cites W2094806500 @default.
- W1854932156 cites W2095356255 @default.
- W1854932156 cites W2104688153 @default.
- W1854932156 cites W2146846049 @default.
- W1854932156 cites W2148654856 @default.
- W1854932156 cites W2156788965 @default.
- W1854932156 cites W2172245690 @default.
- W1854932156 cites W2175259048 @default.
- W1854932156 cites W2183433913 @default.
- W1854932156 cites W2245064272 @default.