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- W1854967502 abstract "Dengue is the most common arthropod-borne viral infection in humans with ∼50 million cases annually worldwide. In recent decades, a steady increase in the number of severe dengue cases has been seen. Severe dengue disease is most often observed in individuals that have pre-existing immunity against heterotypic dengue subtypes and in infants with low levels of maternal dengue antibodies. The generally accepted hypothesis explaining the immunopathogenesis of severe dengue is called antibody-dependent enhancement of dengue infection. Here, circulating antibodies bind to the newly infecting virus but do not neutralize infection. Rather, these antibodies increase the infected cell mass and virus production. Additionally, antiviral responses are diminished allowing massive virus particle production early in infection. The large infected cell mass and the high viral load are prelude for severe disease development. In this review, we discuss what is known about the trafficking of dengue virus in its human host cells, and the signalling pathways activated after virus detection, both in the absence and presence of antibodies against the virus. This review summarizes work that aims to better understand the complex immunopathogenesis of severe dengue disease." @default.
- W1854967502 created "2016-06-24" @default.
- W1854967502 creator A5046661576 @default.
- W1854967502 creator A5047921978 @default.
- W1854967502 creator A5064483158 @default.
- W1854967502 date "2012-10-22" @default.
- W1854967502 modified "2023-09-23" @default.
- W1854967502 title "Molecular Mechanisms Involved in Antibody-Dependent Enhancement of Dengue Virus Infection in Humans" @default.
- W1854967502 cites W110394973 @default.
- W1854967502 cites W1494401243 @default.
- W1854967502 cites W1502104604 @default.
- W1854967502 cites W1570016716 @default.
- W1854967502 cites W1599389506 @default.
- W1854967502 cites W1600846899 @default.
- W1854967502 cites W1622190752 @default.
- W1854967502 cites W1785302422 @default.
- W1854967502 cites W183775175 @default.
- W1854967502 cites W1927805758 @default.
- W1854967502 cites W1928251300 @default.
- W1854967502 cites W1933124086 @default.
- W1854967502 cites W1964276036 @default.
- W1854967502 cites W1964953975 @default.
- W1854967502 cites W1965776698 @default.
- W1854967502 cites W1967327710 @default.
- W1854967502 cites W1967569258 @default.
- W1854967502 cites W1969333701 @default.
- W1854967502 cites W1970136118 @default.
- W1854967502 cites W1971148878 @default.
- W1854967502 cites W1973898630 @default.
- W1854967502 cites W1974811518 @default.
- W1854967502 cites W1978520991 @default.
- W1854967502 cites W1986731224 @default.
- W1854967502 cites W1986813466 @default.
- W1854967502 cites W1987702283 @default.
- W1854967502 cites W1988039566 @default.
- W1854967502 cites W1990757618 @default.
- W1854967502 cites W1998623995 @default.
- W1854967502 cites W2000351107 @default.
- W1854967502 cites W2008169728 @default.
- W1854967502 cites W2008825761 @default.
- W1854967502 cites W2010817652 @default.
- W1854967502 cites W2012826545 @default.
- W1854967502 cites W2012893948 @default.
- W1854967502 cites W2015406420 @default.
- W1854967502 cites W2020259260 @default.
- W1854967502 cites W2021010941 @default.
- W1854967502 cites W2024970900 @default.
- W1854967502 cites W2025494340 @default.
- W1854967502 cites W2027335054 @default.
- W1854967502 cites W2029869358 @default.
- W1854967502 cites W2033702349 @default.
- W1854967502 cites W2036154503 @default.
- W1854967502 cites W2037585075 @default.
- W1854967502 cites W2037599622 @default.
- W1854967502 cites W2039841791 @default.
- W1854967502 cites W2040288464 @default.
- W1854967502 cites W2041414165 @default.
- W1854967502 cites W2047501253 @default.
- W1854967502 cites W2049244598 @default.
- W1854967502 cites W2051298245 @default.
- W1854967502 cites W2051907694 @default.
- W1854967502 cites W2052214918 @default.
- W1854967502 cites W2052669763 @default.
- W1854967502 cites W2056070498 @default.
- W1854967502 cites W2056264877 @default.
- W1854967502 cites W2058757536 @default.
- W1854967502 cites W2059095830 @default.
- W1854967502 cites W2059655994 @default.
- W1854967502 cites W2064790665 @default.
- W1854967502 cites W2067389058 @default.
- W1854967502 cites W2078844752 @default.
- W1854967502 cites W2079083056 @default.
- W1854967502 cites W2080161091 @default.
- W1854967502 cites W2082615190 @default.
- W1854967502 cites W2084224574 @default.
- W1854967502 cites W2084993024 @default.
- W1854967502 cites W2090973041 @default.
- W1854967502 cites W2091058727 @default.
- W1854967502 cites W2091089657 @default.
- W1854967502 cites W2091589417 @default.
- W1854967502 cites W2094487061 @default.
- W1854967502 cites W2095377201 @default.
- W1854967502 cites W2097088780 @default.
- W1854967502 cites W2098447112 @default.
- W1854967502 cites W2099051954 @default.
- W1854967502 cites W2099124165 @default.
- W1854967502 cites W2100720499 @default.
- W1854967502 cites W2100891069 @default.
- W1854967502 cites W2104428288 @default.
- W1854967502 cites W2104609729 @default.
- W1854967502 cites W2105973954 @default.
- W1854967502 cites W2109909805 @default.
- W1854967502 cites W2109993434 @default.
- W1854967502 cites W2111222009 @default.
- W1854967502 cites W2112011162 @default.
- W1854967502 cites W2115832440 @default.
- W1854967502 cites W2116927566 @default.
- W1854967502 cites W2117672421 @default.