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- W185512658 abstract "Activated bleomycin is the drug species seen to be kinetically competent to initiate DNA degradation in the reaction of bleomycin, Fe(II), and O2. It also forms in reactions of bleomycin with Fe(III) and peroxide, or bleomycin with superoxide and either Fe(III) or Fe(II). Efforts to characterize this transient species proceeded by kinetic and spectroscopic strategies. Activated bleomycin now appears to be a drug-ferric-peroxide complex, but this may not be the proximate active drug species. Assuming that activated bleomycin peroxide cleavage yields a reactive product analogous to peroxidase compound I explains many characteristics of bleomycin-mediated DNA degradation reactions. DNA degradation is responsible for the cytotoxic and antitumor activities of this clinically useful antibiotic." @default.
- W185512658 created "2016-06-24" @default.
- W185512658 creator A5037367463 @default.
- W185512658 date "2000-01-01" @default.
- W185512658 modified "2023-10-13" @default.
- W185512658 title "Nature of Activated Bleomycin" @default.
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- W185512658 doi "https://doi.org/10.1007/3-540-46592-8_10" @default.
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