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- W1855148837 abstract "G A A b st ra ct s downregulated in gastric cancer tissues relative to non-tumor gastric mucosae. Downregulation of miR-29c was associated with progression of gastric cancer, and was more prominent in advanced gastric cancers than in gastric adenomas and early gastric cancers (p<0.05). In addition, expression of the oncogene Mcl-1, a target of miR-29c, was significantly increased in gastric cancer tissues relative to non-tumor gastric mucosae. Activation of miR-29c by celecoxib induced suppression of Mcl-1 and apoptosis in gastric cancer cells. Celecoxib activated the expression of miR-29c, but not that of miR-29b, suggesting that celecoxib may modulate the binding of transcriptional factors between miR-29b and miR-29c. The database (www.gene-regulation.com/pub/programs.html), indicated that C/EBPα binding sites were located in the promoter region of miR-29c. The chromatin immunoprecipitation (ChIP) assay showed that immunoprecipitation with the C/EBPα antibody was significantly increased in AGS cells treated with celecoxib, indicating that celecoxib activates the expression of miR29c by enhancing the binding of C/EBPα to the promoter. Conclusions : Downregulation of the tumor suppressor miR-29c plays critical roles in the progression of gastric cancer, and that miR-29c is a novel therapeutic target for gastric cancer. Selective COX-2 inhibitors may have clinical promise for the chemoprevention of gastric cancer via activation ofmiR-29c." @default.
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- W1855148837 date "2011-05-01" @default.
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- W1855148837 title "Nanoparticle-Based Delivery of DCAMKL-1 SiRNA and DAPT Increases MicroRNA-144 and Inhibits Colorectal Cancer Tumor Growth via a Notch-1 Dependent Mechanism" @default.
- W1855148837 doi "https://doi.org/10.1016/s0016-5085(11)60495-2" @default.
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