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• W1855149220 endingPage "1364" @default.
• W1855149220 startingPage "1359" @default.
• W1855149220 abstract "The relationship between myogenin or MyoD expression and hypertrophy of the rat soleus produced either by clenbuterol and 3,3′,5-triiodo-l-thyronine (CT) treatment or by surgical overload was examined. Mature female rats were subjected to surgical overload of the right soleus with the left soleus serving as a control. Another group received the same surgical treatment but were administered CT. Soleus muscles were harvested 4 wk after surgical overload and weighed. Myosin heavy chain isoforms were separated by using polyacrylamide gel electrophoresis while myogenin and MyoD expression were evaluated by Northern analysis. CT and functional overload increased soleus muscle weight. CT treatment induced the appearance of the fast type IIX myosin heavy chain isoform, depressed myogenin expression, and induced MyoD expression. However, functional overload did not alter myogenin or MyoD expression in CT-treated or non-CT-treated rats. Thus pharmacologically and surgically induced hypertrophy have differing effects on myogenin and MyoD expression, because their levels were associated with changes in myosin heavy chain composition (especially type IIX) rather than changes in muscle mass." @default.
• W1855149220 created "2016-06-24" @default.
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• W1855149220 date "1998-04-01" @default.
• W1855149220 modified "2023-10-18" @default.
• W1855149220 title "Myogenin, MyoD, and myosin expression after pharmacologically and surgically induced hypertrophy" @default.
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• W1855149220 doi "https://doi.org/10.1152/jappl.1998.84.4.1359" @default.
• W1855149220 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9516204" @default.
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