Matches in SemOpenAlex for { <https://semopenalex.org/work/W185520192> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W185520192 endingPage "9" @default.
- W185520192 startingPage "303" @default.
- W185520192 abstract "There is increasing interest in the use of combination therapy for rheumatoid arthritis and in the possibility of combining the conventional drug approach with newer antirheumatic therapy. The present study investigates the efficacy of long-term prophylactic enzyme therapy and combination therapy with cyclosporin A in rats with collagen-induced arthritis.Rats with collagen-induced arthritis were administered the following drugs: cyclosporin A (5 mg/kg/day and 10 mg/kg/day orally); a mixture of enzymes containing pure substances (bromelain, trypsin, rutin) in the same ratio as in Phlogenzym (PHL, 150 mg/kg, twice daily intrarectally); and a combination of 5 mg/kg/day cyclosporin A plus 300 mg/kg/day PHL for a period of 50 days from the immunization. Levels of serum albumin, serum nitrite/nitrate concentrations, changes in hind paw swelling and bone erosions were measured in the rats as variables of inflammation and destructive arthritis-associated changes.Treatment with 10 mg/kg cyclosporin A, as well as combination therapy with half dosages of cyclosporin A (5 mg/kg) plus PHL significantly inhibited both inflammation and destructive arthritis-associated changes. Significant differences in favor of combination therapy with 5 mg/kg CsA + 300 mg/kg PHL as compared to 5 mg/kg CsA alone were seen in hind paw swelling. Also, reduction of the radiographic scores was more significant in the combination therapy group. Five mg cyclosporin A or PHL alone reduced the disease markers studied to a lesser extent, and in the case of enzyme therapy this occurred at a later stage of arthritis development.Our results show the inhibitory effect of enzyme therapy on collagen-induced arthritis in rats, as well as the efficacy of cyclosporin A given in low doses in combination with enzyme therapy, which may be useful in the treatment of rheumatoid arthritis." @default.
- W185520192 created "2016-06-24" @default.
- W185520192 creator A5014345828 @default.
- W185520192 creator A5020638275 @default.
- W185520192 creator A5062504235 @default.
- W185520192 creator A5066306496 @default.
- W185520192 date "2001-06-16" @default.
- W185520192 modified "2023-09-30" @default.
- W185520192 title "Inhibitory effect of enzyme therapy and combination therapy with cyclosporin A on collagen-induced arthritis." @default.
- W185520192 cites W1967945028 @default.
- W185520192 cites W1977810943 @default.
- W185520192 cites W2004175072 @default.
- W185520192 cites W2011817958 @default.
- W185520192 cites W2019448678 @default.
- W185520192 cites W2019814232 @default.
- W185520192 cites W2024900049 @default.
- W185520192 cites W2054221939 @default.
- W185520192 cites W2096496996 @default.
- W185520192 cites W2112697533 @default.
- W185520192 cites W2114298357 @default.
- W185520192 cites W2148071155 @default.
- W185520192 cites W2245781626 @default.
- W185520192 cites W2326789779 @default.
- W185520192 cites W2332582491 @default.
- W185520192 cites W2399127856 @default.
- W185520192 cites W2429242578 @default.
- W185520192 cites W2468033783 @default.
- W185520192 cites W91190361 @default.
- W185520192 cites W2470688366 @default.
- W185520192 cites W2491988208 @default.
- W185520192 cites W2516896465 @default.
- W185520192 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11407084" @default.
- W185520192 hasPublicationYear "2001" @default.
- W185520192 type Work @default.
- W185520192 sameAs 185520192 @default.
- W185520192 citedByCount "4" @default.
- W185520192 countsByYear W1855201922014 @default.
- W185520192 countsByYear W1855201922015 @default.
- W185520192 crossrefType "journal-article" @default.
- W185520192 hasAuthorship W185520192A5014345828 @default.
- W185520192 hasAuthorship W185520192A5020638275 @default.
- W185520192 hasAuthorship W185520192A5062504235 @default.
- W185520192 hasAuthorship W185520192A5066306496 @default.
- W185520192 hasConcept C126322002 @default.
- W185520192 hasConcept C162156334 @default.
- W185520192 hasConcept C2776999253 @default.
- W185520192 hasConcept C2777077863 @default.
- W185520192 hasConcept C2777575956 @default.
- W185520192 hasConcept C71924100 @default.
- W185520192 hasConcept C98274493 @default.
- W185520192 hasConceptScore W185520192C126322002 @default.
- W185520192 hasConceptScore W185520192C162156334 @default.
- W185520192 hasConceptScore W185520192C2776999253 @default.
- W185520192 hasConceptScore W185520192C2777077863 @default.
- W185520192 hasConceptScore W185520192C2777575956 @default.
- W185520192 hasConceptScore W185520192C71924100 @default.
- W185520192 hasConceptScore W185520192C98274493 @default.
- W185520192 hasIssue "3" @default.
- W185520192 hasLocation W1855201921 @default.
- W185520192 hasOpenAccess W185520192 @default.
- W185520192 hasPrimaryLocation W1855201921 @default.
- W185520192 hasRelatedWork W1527365325 @default.
- W185520192 hasRelatedWork W2022360783 @default.
- W185520192 hasRelatedWork W2078067100 @default.
- W185520192 hasRelatedWork W2137851845 @default.
- W185520192 hasRelatedWork W2313909601 @default.
- W185520192 hasRelatedWork W2362768479 @default.
- W185520192 hasRelatedWork W2397597566 @default.
- W185520192 hasRelatedWork W2473401012 @default.
- W185520192 hasRelatedWork W2602481810 @default.
- W185520192 hasRelatedWork W4247887685 @default.
- W185520192 hasVolume "19" @default.
- W185520192 isParatext "false" @default.
- W185520192 isRetracted "false" @default.
- W185520192 magId "185520192" @default.
- W185520192 workType "article" @default.