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- W1855261552 abstract "Objective To determine the association of body mass index (BMI) with incidence and progression of knee effusion on magnetic resonance imaging (MRI) and physical examination (PE) in a longitudinal cohort with knee pain. Methods A population‐based cohort was assessed at baseline and 3 years (n = 163). BMI was categorized as normal (<25), overweight (25–29.9), and obese (≥30). Knee effusion was graded as 0–3 (absent/mild/moderate/severe) on MRI and 0–1 (absent/present) on PE. Progression of MRI effusion (MRI eff ) was an increase of ≥1 grade in those with grade 1 or 2 at baseline. Incident MRI eff and PE effusion (PE eff ) were any effusion at followup (>0) in those with grade 0 at baseline. A second type of incident MRI eff was effusion grade ≥2 at followup in those with grade <2 at baseline. Exponential regression analysis was used, adjusted for age, sex, and radiographic severity. Results Incident MRI eff ≥1, incident MRI eff ≥2, incident PE eff , and progression of MRI eff were seen in 14 of 73 (19%), 18 of 140 (13%), 26 of 127 (20%), and 18 of 86 (21%), respectively. There was a borderline statistical association of obesity with progression of MRI eff (hazard ratio [HR] 3.3 [95% confidence interval (95% CI) 1.0–11.2]) and with incident MRI eff ≥2 (HR 3.4 [95% CI 1.0–11.5]). BMI was not associated with incident MRI eff ≥1 (HR overweight 1.1 [95% CI 0.3–3.6], obese 1.0 [95% CI 0.2–5.0]). Overweight was associated with incident PE eff (HR 4.5 [95% CI 1.4–14.2]), while obesity was not statistically significant (HR 3.1 [95% CI 0.9–11.1]). Conclusion Obesity was a risk factor for incident and progressive knee effusion in this population‐based cohort. These findings highlight an important link between obesity and inflammation in knee osteoarthritis." @default.
- W1855261552 created "2016-06-24" @default.
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- W1855261552 date "2016-03-24" @default.
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- W1855261552 title "Association of Body Mass Index With Incidence and Progression of Knee Effusion on Magnetic Resonance Imaging and on Knee Examination" @default.
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- W1855261552 doi "https://doi.org/10.1002/acr.22714" @default.
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