FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1855295630> ?p ?o ?g. }

• W1855295630 endingPage "R569" @default.
• W1855295630 startingPage "R569" @default.
• W1855295630 abstract "At present only few biological data are available to indicate whether psoriatic arthritis (PsA) is part of the spondyloarthropathy (SpA) concept, whether it is a separate disease entity or a heterogeneous disease group with oligoarticular/axial forms belonging to SpA and polyarticular forms resembling rheumatoid arthritis (RA). To address this issue with regard to peripheral synovitis, we compared the synovial characteristics of PsA with those of ankylosing spondylitis (AS)/undifferentiated SpA (USpA) and RA, and compared the synovium of oligoarticular versus polyarticular PsA. Synovial biopsies were obtained from patients with RA, nonpsoriatic SpA (AS + USpA), and oligoarticular and polyarticular PsA. The histological analysis included examination(s) of the lining layer thickness, vascularity, cellular infiltration, lymphoid aggregates, plasma cells and neutrophils. Also, we performed immunohistochemical assessments of CD3, CD4, CD8, CD20, CD38, CD138, CD68, CD163, CD83, CD1a, CD146, alphaVbeta3, E-selectin, intercellular adhesion molecule-1, vascular cell adhesion molecule-1, S100A12, intracellular citrullinated proteins and major histocompatibility complex (MHC)-human cartilage (HC) gp39 peptide complexes. Comparing SpA (PsA + AS + USpA) with RA, vascularity, and neutrophil and CD163+ macrophage counts were greater in SpA (P < 0.05), whereas lining layer thickness and the number of CD83+ dendritic cells were greater in RA (P < 0.05). In RA, 44% of samples exhibited positive staining for intracellular citrullinated proteins and 46% for MHC-HC gp39 peptide complexes, whereas no staining for these markers was observed in SpA samples. We excluded influences of disease-modifying antirheumatic drug and/or corticosteroid treatment by conducting systematic analyses of treated and untreated subgroups. Focusing on PsA, no significant differences were observed between PsA and nonpsoriatic SpA. In contrast, vascularity (P < 0.001) and neutrophils were increased in PsA as compared with RA (P = 0.010), whereas staining for intracellular citrullinated proteins and MHC-HC gp39 peptide complexes was exclusively observed in RA (both P = 0.001), indicating that the same discriminating features are found in PsA and other SpA subtypes compared with RA. Exploring synovial histopathology between oligoarticular and polyarticular PsA, no significant differences were noted. Moreover, intracellular citrullinated proteins and MHC-HC gp39 peptide complexes, which are specific markers for RA, were observed in neither oligoarticular nor polyarticular PsA. Taken together, these data indicate that the synovial histopathology of PsA, either oligoarticular or polyarticular, resembles that of other SpA subtypes, whereas both groups can be differentiated from RA on the basis of these same synovial features, suggesting that peripheral synovitis in PsA belongs to the SpA concept." @default.
• W1855295630 created "2016-06-24" @default.
• W1855295630 creator A5005788294 @default.
• W1855295630 creator A5040230445 @default.
• W1855295630 creator A5046625022 @default.
• W1855295630 creator A5046982040 @default.
• W1855295630 creator A5051478646 @default.
• W1855295630 creator A5053979605 @default.
• W1855295630 creator A5063516762 @default.
• W1855295630 creator A5069497341 @default.
• W1855295630 creator A5074618900 @default.
• W1855295630 creator A5085069467 @default.
• W1855295630 date "2005-01-01" @default.
• W1855295630 modified "2023-10-01" @default.
• W1855295630 cites W1221104476 @default.
• W1855295630 cites W1624022481 @default.
• W1855295630 cites W1864496754 @default.
• W1855295630 cites W1966756689 @default.
• W1855295630 cites W1968619512 @default.
• W1855295630 cites W1972413207 @default.
• W1855295630 cites W1975536411 @default.
• W1855295630 cites W1977880923 @default.
• W1855295630 cites W1984663399 @default.
• W1855295630 cites W1986397670 @default.
• W1855295630 cites W1986755404 @default.
• W1855295630 cites W1990072589 @default.
• W1855295630 cites W2024401594 @default.
• W1855295630 cites W2033015934 @default.
• W1855295630 cites W2037976962 @default.
• W1855295630 cites W2040243426 @default.
• W1855295630 cites W2042136358 @default.
• W1855295630 cites W2043024980 @default.
• W1855295630 cites W2051880698 @default.
• W1855295630 cites W2058335157 @default.
• W1855295630 cites W2059529519 @default.
• W1855295630 cites W2073177499 @default.
• W1855295630 cites W2074840614 @default.
• W1855295630 cites W2076961991 @default.
• W1855295630 cites W2084785618 @default.
• W1855295630 cites W2096692775 @default.
• W1855295630 cites W2104226576 @default.
• W1855295630 cites W2106036990 @default.
• W1855295630 cites W2108743567 @default.
• W1855295630 cites W2109909401 @default.
• W1855295630 cites W2116576448 @default.
• W1855295630 cites W2124162112 @default.
• W1855295630 cites W2127438223 @default.
• W1855295630 cites W2129685099 @default.
• W1855295630 cites W2145108764 @default.
• W1855295630 cites W2147696136 @default.
• W1855295630 cites W2152348310 @default.
• W1855295630 cites W2157773524 @default.
• W1855295630 cites W2167643233 @default.
• W1855295630 cites W2170119271 @default.
• W1855295630 cites W2171544015 @default.
• W1855295630 cites W2207628552 @default.
• W1855295630 cites W2403187935 @default.
• W1855295630 cites W4256490618 @default.
• W1855295630 doi "https://doi.org/10.1186/ar1698" @default.
• W1855295630 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1174942" @default.
• W1855295630 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15899044" @default.
• W1855295630 hasPublicationYear "2005" @default.
• W1855295630 type Work @default.
• W1855295630 sameAs 1855295630 @default.
• W1855295630 citedByCount "226" @default.
• W1855295630 countsByYear W18552956302012 @default.
• W1855295630 countsByYear W18552956302013 @default.
• W1855295630 countsByYear W18552956302014 @default.
• W1855295630 countsByYear W18552956302015 @default.
• W1855295630 countsByYear W18552956302016 @default.
• W1855295630 countsByYear W18552956302017 @default.
• W1855295630 countsByYear W18552956302018 @default.
• W1855295630 countsByYear W18552956302019 @default.
• W1855295630 countsByYear W18552956302020 @default.
• W1855295630 countsByYear W18552956302021 @default.
• W1855295630 countsByYear W18552956302022 @default.
• W1855295630 countsByYear W18552956302023 @default.
• W1855295630 crossrefType "journal-article" @default.
• W1855295630 hasAuthorship W1855295630A5005788294 @default.
• W1855295630 hasAuthorship W1855295630A5040230445 @default.
• W1855295630 hasAuthorship W1855295630A5046625022 @default.
• W1855295630 hasAuthorship W1855295630A5046982040 @default.
• W1855295630 hasAuthorship W1855295630A5051478646 @default.
• W1855295630 hasAuthorship W1855295630A5053979605 @default.
• W1855295630 hasAuthorship W1855295630A5063516762 @default.
• W1855295630 hasAuthorship W1855295630A5069497341 @default.
• W1855295630 hasAuthorship W1855295630A5074618900 @default.
• W1855295630 hasAuthorship W1855295630A5085069467 @default.
• W1855295630 hasBestOaLocation W18552956301 @default.
• W1855295630 hasConcept C142724271 @default.
• W1855295630 hasConcept C202751555 @default.
• W1855295630 hasConcept C203014093 @default.
• W1855295630 hasConcept C2775858924 @default.
• W1855295630 hasConcept C2777575956 @default.
• W1855295630 hasConcept C2779244835 @default.
• W1855295630 hasConcept C2779244956 @default.
• W1855295630 hasConcept C55493867 @default.
• W1855295630 hasConcept C71924100 @default.

• next