FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1855514942> ?p ?o ?g. }

• W1855514942 endingPage "3283" @default.
• W1855514942 startingPage "3277" @default.
• W1855514942 abstract "The bursa of Fabricius is a central organ for chicken B cell development and provides an essential microenvironment for expansion of the B cell pool and for generation of a diversified B cell repertoire. We report here that genes encoding the Notch family of transmembrane proteins, key regulators of cell fate determination in development, are differentially expressed in the bursa of Fabricius: Notch1 is expressed in medullary B cells located close to the basement membrane-associated epithelium (BMAE). In contrast, a Notch ligand, Serrate2, is expressed exclusively in the BMAE, which surrounds bursal medulla. A basic helix-loop-helix-type transcription factor, Hairy1, a downstream target of Notch signaling, is expressed in the bursa coordinately with Notch1 and Serrate2 and an immature B cell line, TLT1, which expresses both Notch1 and Serrate2. Furthermore, stable expression of a constitutively active form of chicken Notch1 or Notch2 in a B cell line results in a down-regulation of surface IgM expression, which is accompanied by the reduction of IgH gene transcripts. Transient reporter assay with the human IgH gene intronic enhancer reveals that an active form of Notch1 inhibits the IgH enhancer activity in chicken B cells, suggesting that Notch-mediated signals suppress the IgH gene expression via influencing the IgH intronic enhancer. These findings raise the possibility that the local activation of Notch1 in a subset of B cells by Serrate2 expressed in BMAE may influence the cell fate decision that is involved in B cell differentiation and selection inside the bursa." @default.
• W1855514942 created "2016-06-24" @default.
• W1855514942 creator A5002128951 @default.
• W1855514942 creator A5009844609 @default.
• W1855514942 creator A5025143550 @default.
• W1855514942 creator A5025890679 @default.
• W1855514942 date "2001-03-01" @default.
• W1855514942 modified "2023-10-12" @default.
• W1855514942 title "Notch Signaling Suppresses IgH Gene Expression in Chicken B Cells: Implication in Spatially Restricted Expression of Serrate2/Notch1 in the Bursa of Fabricius" @default.
• W1855514942 cites W1436270903 @default.
• W1855514942 cites W1532578391 @default.
• W1855514942 cites W1536617935 @default.
• W1855514942 cites W1911156364 @default.
• W1855514942 cites W1942308012 @default.
• W1855514942 cites W1968561263 @default.
• W1855514942 cites W1975344153 @default.
• W1855514942 cites W1980212327 @default.
• W1855514942 cites W1981780292 @default.
• W1855514942 cites W1984528690 @default.
• W1855514942 cites W1995900441 @default.
• W1855514942 cites W2007518207 @default.
• W1855514942 cites W2009798257 @default.
• W1855514942 cites W2013946603 @default.
• W1855514942 cites W2014549199 @default.
• W1855514942 cites W2025640975 @default.
• W1855514942 cites W2025804504 @default.
• W1855514942 cites W2031018864 @default.
• W1855514942 cites W2046928493 @default.
• W1855514942 cites W2047554700 @default.
• W1855514942 cites W2051113765 @default.
• W1855514942 cites W2057647863 @default.
• W1855514942 cites W2057902325 @default.
• W1855514942 cites W2062084323 @default.
• W1855514942 cites W2064646902 @default.
• W1855514942 cites W2073803712 @default.
• W1855514942 cites W2074159015 @default.
• W1855514942 cites W2078298224 @default.
• W1855514942 cites W2081989598 @default.
• W1855514942 cites W2083280774 @default.
• W1855514942 cites W2083847717 @default.
• W1855514942 cites W2087438783 @default.
• W1855514942 cites W2088539039 @default.
• W1855514942 cites W2092185055 @default.
• W1855514942 cites W2099770647 @default.
• W1855514942 cites W2099878990 @default.
• W1855514942 cites W2107439277 @default.
• W1855514942 cites W2108491220 @default.
• W1855514942 cites W2109023863 @default.
• W1855514942 cites W2111608867 @default.
• W1855514942 cites W2118623951 @default.
• W1855514942 cites W2134664396 @default.
• W1855514942 cites W2138301962 @default.
• W1855514942 cites W2139839202 @default.
• W1855514942 cites W2144868620 @default.
• W1855514942 cites W2157332137 @default.
• W1855514942 cites W2160082285 @default.
• W1855514942 cites W2163584800 @default.
• W1855514942 cites W2165684064 @default.
• W1855514942 cites W2168956456 @default.
• W1855514942 cites W2192002059 @default.
• W1855514942 cites W4230605418 @default.
• W1855514942 cites W4243305338 @default.
• W1855514942 cites W4243481069 @default.
• W1855514942 cites W4254138670 @default.
• W1855514942 cites W8143991 @default.
• W1855514942 doi "https://doi.org/10.4049/jimmunol.166.5.3277" @default.
• W1855514942 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11207282" @default.
• W1855514942 hasPublicationYear "2001" @default.
• W1855514942 type Work @default.
• W1855514942 sameAs 1855514942 @default.
• W1855514942 citedByCount "38" @default.
• W1855514942 countsByYear W18555149422012 @default.
• W1855514942 countsByYear W18555149422013 @default.
• W1855514942 countsByYear W18555149422014 @default.
• W1855514942 countsByYear W18555149422015 @default.
• W1855514942 countsByYear W18555149422022 @default.
• W1855514942 countsByYear W18555149422023 @default.
• W1855514942 crossrefType "journal-article" @default.
• W1855514942 hasAuthorship W1855514942A5002128951 @default.
• W1855514942 hasAuthorship W1855514942A5009844609 @default.
• W1855514942 hasAuthorship W1855514942A5025143550 @default.
• W1855514942 hasAuthorship W1855514942A5025890679 @default.
• W1855514942 hasBestOaLocation W18555149421 @default.
• W1855514942 hasConcept C104317684 @default.
• W1855514942 hasConcept C111936080 @default.
• W1855514942 hasConcept C153911025 @default.
• W1855514942 hasConcept C159654299 @default.
• W1855514942 hasConcept C161879069 @default.
• W1855514942 hasConcept C163952510 @default.
• W1855514942 hasConcept C196978929 @default.
• W1855514942 hasConcept C2778453870 @default.
• W1855514942 hasConcept C54355233 @default.
• W1855514942 hasConcept C62478195 @default.
• W1855514942 hasConcept C86339819 @default.
• W1855514942 hasConcept C86803240 @default.
• W1855514942 hasConcept C8891405 @default.
• W1855514942 hasConcept C95444343 @default.
• W1855514942 hasConceptScore W1855514942C104317684 @default.

• next