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• W1855576478 endingPage "3659" @default.
• W1855576478 startingPage "3646" @default.
• W1855576478 abstract "Following a standard heat shock, approximately 40% of Hsp70 transcripts in Drosophila melanogaster lack a poly(A) tail. Since heat shock disrupts other aspects of RNA processing, this observation suggested that heat might disrupt polyadenylation as well. We find, however, that as the temperature is increased a larger fraction of Hsp70 RNA is polyadenylated. Poly(A)-deficient Hsp70 RNAs arise not from a failure in polyadenylation but from the rapid and selective removal of poly(A) from previously adenylated transcripts. Poly(A) removal is highly regulated: poly(A) is (i) removed much more rapidly from Hsp70 RNAs than from Hsp23 RNAs, (ii) removed more rapidly after mild heat shocks than after severe heat shocks, and (iii) removed more rapidly after a severe heat shock if cells have first been conditioned by a mild heat treatment. Poly(A) seems to be removed by simple deadenylation rather than by endonucleolytic cleavage 5' of the adenylation site. During recovery from heat shock, deadenylation is rapidly followed by degradation. In cells maintained at high temperatures, however, the two processes are uncoupled and Hsp70 RNAs are deadenylated without being degraded. These deadenylated mRNAs are translated with low efficiency. Deadenylation therefore allows Hsp70 synthesis to be repressed even when degradation of the mRNA is blocked. Poly(A) tail shortening appears to play a key role in regulating Hsp70 expression." @default.
• W1855576478 created "2016-06-24" @default.
• W1855576478 creator A5019700045 @default.
• W1855576478 creator A5032386151 @default.
• W1855576478 creator A5090712336 @default.
• W1855576478 date "1994-06-01" @default.
• W1855576478 modified "2023-10-18" @default.
• W1855576478 title "Preferential deadenylation of Hsp70 mRNA plays a key role in regulating Hsp70 expression in Drosophila melanogaster." @default.
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• W1855576478 doi "https://doi.org/10.1128/mcb.14.6.3646" @default.
• W1855576478 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/358732" @default.

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