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• W1855716997 abstract "The mode of action of the anxiolytic medicinal plant Souroubea sympetala was investigated to test the hypothesis that extracts and the active principle act at the pharmacologically important GABA A –benzodiazepine (GABA A –BZD) receptor. Leaf extracts prepared by ethyl acetate extraction or supercritical extraction, previously determined to have 5.54 mg/g and 6.78 mg/g of the active principle, betulinic acid, respectively, reduced behavioural parameters associated with anxiety in a rat model. When animals were pretreated with the GABA A –BZD receptor antagonist flumazenil, followed by the plant extracts, or a more soluble derivative of the active principle, the methyl ester of betulinic acid (MeBA), flumazenil eliminated the anxiety-reducing effect of plant extracts and MeBA, demonstrating that S. sympetala acts via an agonist action on the GABA A –BZD receptor. An in vitro GABA A –BZD competitive receptor binding assay also demonstrated that S. sympetala extracts have an affinity for the GABA A –BZD receptor, with an EC 50 value of 123 μg/mL (EtOAc leaf extract) and 154 μg/mL (supercritical CO 2 extract). These experiments indicate that S. sympetala acts at the GABA A –BZD receptor to elicit anxiolysis." @default.
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• W1855716997 date "2014-09-01" @default.
• W1855716997 modified "2023-10-17" @default.
• W1855716997 title "<i>Souroubea sympetala</i> (Marcgraviaceae): a medicinal plant that exerts anxiolysis through interaction with the GABA_A benzodiazepine receptor" @default.
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• W1855716997 doi "https://doi.org/10.1139/cjpp-2014-0213" @default.
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