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- W1855795036 abstract "Introduction: In Obesity-Hypoventilation-Syndrome (OHS), pulmonary hypertension (PH) is considered a common feature. Aims: To determine frequency and severity of PH in OHS patients treated with non-invasive pressure ventilation (NPPV). Methods: Prospective cross-sectional study of consecutive patients admitted for follow-up of NPPV (initiated ≥3 months before). OHS was defined by BMI≥30kg/m 2 , capillary carbondioxid tension (PaCO 2 )≥45mmHg prior NPPV initiation without other causes for hypoventilation. Right-heart catheterization (RHC) was performed at rest without oxygen supplementation, daytime sleepiness measured by Epworth Sleepiness Scale (ESS). Results: 177 patients considered to have OHS were screened. Among 64 patients who met the diagnosis criteria for OHS, 21 patients (10f, 11m; median age 62.2 [53.9;71.7] years, BMI 45 [40;53] kg/m 2 , PaCO 2 39.6 [37.8;45.5] mmHg) gave consent for RHC. Only 4 (19%) patients had normal mean pulmonary artery pressure (mPAP 2 /cm 5 ; 8 patients (38.1%) presented with “Borderline”-PH (mPAP 20-24mmHg), mPAP 22 [22.5;23] mmHg and PVRI 392 [287;485] and 9 patients (42.9%) had a manifest PH (mPAP≥25mmHg), mPAP 33 [29;34] mmHg and PVRI 440 [384;728]. In 3 patients with PH, pulmonary capillary wedge pressure was >15mmHg; 2 of them presented with transpulmonary pressure gradient >12mmHg. In patients with PH, ESS (7 [6;11]) was significantly higher than in those without PH (3 [0.5;5.5], p=0.03) or Borderline-PH (3.5 [2.5;6.5], p=0.03). Conclusion: Mild to moderate PH is quite frequent in OHS, even after initiation of NPPV. Its impact on survival and quality of life has to be studied in future trials." @default.
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- W1855795036 date "2011-09-01" @default.
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- W1855795036 title "Pulmonary hypertension in obesity-hypoventilation-syndrome" @default.
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