Matches in SemOpenAlex for { <https://semopenalex.org/work/W1855876669> ?p ?o ?g. }
- W1855876669 endingPage "1265" @default.
- W1855876669 startingPage "1257" @default.
- W1855876669 abstract "A major site of DNA bending is located 1.6 kb upstream of the P1 transcription start site of the human c-myc gene, near the center of a reported zone of initiation of DNA replication. A repeated, purine-rich element, termed PUR, at the bend site is specifically bound by a protein in HeLa cell nuclear extracts. This protein has specific affinity for the purine-rich single strand of the element. Methylation interference maps a pattern of specific contact points with guanosine bases in a 24-mer oligonucleotide containing the element. UV cross-linking reveals that contact is made by a polypeptide of approximately 28 kDa. The PUR element is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. The consensus sequence GGNNGAGGGAGARRRR has been derived. This element is present near centers of regions of two mammalian loci (human c-myc and hamster dhfr) recently reported as initiation zones for DNA replication. A 24-mer oligonucleotide representing the hamster dhfr version of the PUR element effectively competes with the human c-myc version for binding to Pur." @default.
- W1855876669 created "2016-06-24" @default.
- W1855876669 creator A5042577601 @default.
- W1855876669 creator A5084141911 @default.
- W1855876669 date "1992-03-01" @default.
- W1855876669 modified "2023-10-11" @default.
- W1855876669 title "The HeLa Pur factor binds single-stranded DNA at a specific element conserved in gene flanking regions and origins of DNA replication." @default.
- W1855876669 cites W108647400 @default.
- W1855876669 cites W1558516755 @default.
- W1855876669 cites W1762516998 @default.
- W1855876669 cites W1775131438 @default.
- W1855876669 cites W1849982644 @default.
- W1855876669 cites W1855074355 @default.
- W1855876669 cites W1857926442 @default.
- W1855876669 cites W1909586281 @default.
- W1855876669 cites W1945304539 @default.
- W1855876669 cites W1964262489 @default.
- W1855876669 cites W1967427366 @default.
- W1855876669 cites W1967932844 @default.
- W1855876669 cites W1977751950 @default.
- W1855876669 cites W1978853657 @default.
- W1855876669 cites W1990731600 @default.
- W1855876669 cites W1991826157 @default.
- W1855876669 cites W1993243592 @default.
- W1855876669 cites W1994038589 @default.
- W1855876669 cites W1997986439 @default.
- W1855876669 cites W1998058932 @default.
- W1855876669 cites W2001725306 @default.
- W1855876669 cites W2009230618 @default.
- W1855876669 cites W2014141253 @default.
- W1855876669 cites W2015249727 @default.
- W1855876669 cites W2030663089 @default.
- W1855876669 cites W2031408368 @default.
- W1855876669 cites W2033706348 @default.
- W1855876669 cites W2038874225 @default.
- W1855876669 cites W2041031381 @default.
- W1855876669 cites W2041401543 @default.
- W1855876669 cites W2043592675 @default.
- W1855876669 cites W2044060614 @default.
- W1855876669 cites W2053285252 @default.
- W1855876669 cites W2060230514 @default.
- W1855876669 cites W2063443838 @default.
- W1855876669 cites W2077790814 @default.
- W1855876669 cites W2079078652 @default.
- W1855876669 cites W2080835352 @default.
- W1855876669 cites W2082534786 @default.
- W1855876669 cites W2084874442 @default.
- W1855876669 cites W2088701644 @default.
- W1855876669 cites W2090081894 @default.
- W1855876669 cites W2092769914 @default.
- W1855876669 cites W2101448549 @default.
- W1855876669 cites W2110843283 @default.
- W1855876669 cites W2128569886 @default.
- W1855876669 cites W2140339874 @default.
- W1855876669 cites W2152300974 @default.
- W1855876669 cites W2169595922 @default.
- W1855876669 cites W2172096382 @default.
- W1855876669 cites W2173708640 @default.
- W1855876669 cites W2277842483 @default.
- W1855876669 cites W2406309171 @default.
- W1855876669 doi "https://doi.org/10.1128/mcb.12.3.1257" @default.
- W1855876669 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/369558" @default.
- W1855876669 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1545807" @default.
- W1855876669 hasPublicationYear "1992" @default.
- W1855876669 type Work @default.
- W1855876669 sameAs 1855876669 @default.
- W1855876669 citedByCount "159" @default.
- W1855876669 countsByYear W18558766692013 @default.
- W1855876669 countsByYear W18558766692014 @default.
- W1855876669 countsByYear W18558766692015 @default.
- W1855876669 countsByYear W18558766692016 @default.
- W1855876669 countsByYear W18558766692017 @default.
- W1855876669 countsByYear W18558766692018 @default.
- W1855876669 countsByYear W18558766692019 @default.
- W1855876669 countsByYear W18558766692020 @default.
- W1855876669 countsByYear W18558766692021 @default.
- W1855876669 countsByYear W18558766692022 @default.
- W1855876669 countsByYear W18558766692023 @default.
- W1855876669 crossrefType "journal-article" @default.
- W1855876669 hasAuthorship W1855876669A5042577601 @default.
- W1855876669 hasAuthorship W1855876669A5084141911 @default.
- W1855876669 hasBestOaLocation W18558766692 @default.
- W1855876669 hasConcept C101762097 @default.
- W1855876669 hasConcept C104317684 @default.
- W1855876669 hasConcept C129312508 @default.
- W1855876669 hasConcept C132376346 @default.
- W1855876669 hasConcept C150194340 @default.
- W1855876669 hasConcept C151158763 @default.
- W1855876669 hasConcept C153911025 @default.
- W1855876669 hasConcept C54355233 @default.
- W1855876669 hasConcept C552990157 @default.
- W1855876669 hasConcept C58337764 @default.
- W1855876669 hasConcept C73573662 @default.
- W1855876669 hasConcept C86803240 @default.
- W1855876669 hasConcept C98086919 @default.
- W1855876669 hasConceptScore W1855876669C101762097 @default.
- W1855876669 hasConceptScore W1855876669C104317684 @default.
- W1855876669 hasConceptScore W1855876669C129312508 @default.