FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1856147497> ?p ?o ?g. }

• W1856147497 endingPage "29" @default.
• W1856147497 startingPage "21" @default.
• W1856147497 abstract "The endogenous reactive oxygen species (“ ROS”) formation is associated with many pathologic states such as inflammatory diseases, neurodegenerative diseases, brain and heart ischemic injuries, cancer, and aging. The purpose of this study was to investigate the endogenous sources for “ROS” formation in intact isolated rat hepatocytes, in particular, peroxisomal oxidases, monoamine oxidase, xanthine oxidase, cytochrome P450, and mitochondria electron transport. The rat hepatocyte cat alyzed oxidation of 2',7'dichlorofluores cin to form the fluorescent 2,7'-dichlorofluorescein was used to measure endogenous and xenobiotic-induced reactive oxygen speci es (“ ROS”) formation by intact isolated rat hepatocytes. Various oxidase substrates and inhibitors were then used to identify the intracellular oxidases responsible. Endogenous “ ROS” formation was markedly increased in catalas e inhibited or GSH depleted hepatocytes, and was inhibited by “ ROS” scavengers or des feroxamine. Endogenous “ ROS” formation was also inhibited by cytochrome P450 inhibitors, but was not affected by oxypurinol, a xanthine oxidase inhibitor. Mitochondrial respiratory chain inhibitors or hypoxia, on the other hand, markedly increas ed “ ROS” before cytotoxicity ensued. This suggests endogenous “ ROS” formation can largely be attributed to oxygen reduction by reduced mitochondrial el ectron transport components and reduced cytochrome P450 isozymes. Addition of monoamine oxidase substrat es increased antimycin Aresistant respiration and “ ROS” formation before cytotoxicity ensued. On the other hand peroxisomal substrates readily induced “ ROS” form ation and were cytotoxic towards catalas e inhibited hepatocytes, which suggests that peroxisomal catalase removes endogenous H2O2 formed in the peroxisomes. The cons equences of upregulation of peroxisomal oxidases are discussed." @default.
• W1856147497 created "2016-06-24" @default.
• W1856147497 creator A5064230925 @default.
• W1856147497 date "2002-01-01" @default.
• W1856147497 modified "2023-09-25" @default.
• W1856147497 title "Identification of Intracellular Sources Responsible for Endogenous Reactive Oxygen Species Formation" @default.
• W1856147497 cites W1479692774 @default.
• W1856147497 cites W1895145214 @default.
• W1856147497 cites W1966072897 @default.
• W1856147497 cites W1970508003 @default.
• W1856147497 cites W1974505849 @default.
• W1856147497 cites W1986193590 @default.
• W1856147497 cites W1986908417 @default.
• W1856147497 cites W1996066410 @default.
• W1856147497 cites W2002630124 @default.
• W1856147497 cites W2004691367 @default.
• W1856147497 cites W2011606516 @default.
• W1856147497 cites W2019411611 @default.
• W1856147497 cites W2022627623 @default.
• W1856147497 cites W2023768473 @default.
• W1856147497 cites W2029494385 @default.
• W1856147497 cites W2030582707 @default.
• W1856147497 cites W2037246989 @default.
• W1856147497 cites W2047558574 @default.
• W1856147497 cites W2051004563 @default.
• W1856147497 cites W2057810394 @default.
• W1856147497 cites W2060363769 @default.
• W1856147497 cites W2071795040 @default.
• W1856147497 cites W2072415705 @default.
• W1856147497 cites W2072673974 @default.
• W1856147497 cites W2081808451 @default.
• W1856147497 cites W2084774843 @default.
• W1856147497 cites W2107748018 @default.
• W1856147497 cites W2113966207 @default.
• W1856147497 cites W2143993280 @default.
• W1856147497 cites W2146686780 @default.
• W1856147497 cites W2163058387 @default.
• W1856147497 cites W2254316935 @default.
• W1856147497 cites W2271272206 @default.
• W1856147497 cites W2404705955 @default.
• W1856147497 cites W2411025042 @default.
• W1856147497 cites W78793193 @default.
• W1856147497 cites W88113176 @default.
• W1856147497 doi "https://doi.org/10.22037/ijpr.2010.4" @default.
• W1856147497 hasPublicationYear "2002" @default.
• W1856147497 type Work @default.
• W1856147497 sameAs 1856147497 @default.
• W1856147497 citedByCount "3" @default.
• W1856147497 countsByYear W18561474972013 @default.
• W1856147497 crossrefType "journal-article" @default.
• W1856147497 hasAuthorship W1856147497A5064230925 @default.
• W1856147497 hasConcept C104317684 @default.
• W1856147497 hasConcept C127078168 @default.
• W1856147497 hasConcept C16613235 @default.
• W1856147497 hasConcept C181199279 @default.
• W1856147497 hasConcept C185592680 @default.
• W1856147497 hasConcept C2776151105 @default.
• W1856147497 hasConcept C2777497464 @default.
• W1856147497 hasConcept C2778102346 @default.
• W1856147497 hasConcept C2778175917 @default.
• W1856147497 hasConcept C2778979269 @default.
• W1856147497 hasConcept C2781188418 @default.
• W1856147497 hasConcept C28859421 @default.
• W1856147497 hasConcept C48349386 @default.
• W1856147497 hasConcept C55493867 @default.
• W1856147497 hasConcept C86803240 @default.
• W1856147497 hasConcept C95444343 @default.
• W1856147497 hasConceptScore W1856147497C104317684 @default.
• W1856147497 hasConceptScore W1856147497C127078168 @default.
• W1856147497 hasConceptScore W1856147497C16613235 @default.
• W1856147497 hasConceptScore W1856147497C181199279 @default.
• W1856147497 hasConceptScore W1856147497C185592680 @default.
• W1856147497 hasConceptScore W1856147497C2776151105 @default.
• W1856147497 hasConceptScore W1856147497C2777497464 @default.
• W1856147497 hasConceptScore W1856147497C2778102346 @default.
• W1856147497 hasConceptScore W1856147497C2778175917 @default.
• W1856147497 hasConceptScore W1856147497C2778979269 @default.
• W1856147497 hasConceptScore W1856147497C2781188418 @default.
• W1856147497 hasConceptScore W1856147497C28859421 @default.
• W1856147497 hasConceptScore W1856147497C48349386 @default.
• W1856147497 hasConceptScore W1856147497C55493867 @default.
• W1856147497 hasConceptScore W1856147497C86803240 @default.
• W1856147497 hasConceptScore W1856147497C95444343 @default.
• W1856147497 hasIssue "1" @default.
• W1856147497 hasLocation W18561474971 @default.
• W1856147497 hasOpenAccess W1856147497 @default.
• W1856147497 hasPrimaryLocation W18561474971 @default.
• W1856147497 hasRelatedWork W1554017667 @default.
• W1856147497 hasRelatedWork W1843780579 @default.
• W1856147497 hasRelatedWork W1965746568 @default.
• W1856147497 hasRelatedWork W1966067605 @default.
• W1856147497 hasRelatedWork W1980959883 @default.
• W1856147497 hasRelatedWork W1982574557 @default.
• W1856147497 hasRelatedWork W1984205437 @default.
• W1856147497 hasRelatedWork W1994465694 @default.
• W1856147497 hasRelatedWork W2015302405 @default.
• W1856147497 hasRelatedWork W2018384469 @default.
• W1856147497 hasRelatedWork W2030967970 @default.

• next