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• W1856173697 endingPage "641" @default.
• W1856173697 startingPage "629" @default.
• W1856173697 abstract "In magnocellular neurones of the supraoptic nucleus (SON), the neuropeptides vasopressin and oxytocin are synthesised and packaged into large dense-cored vesicles (LDCVs). These vesicles undergo regulated exocytosis from nerve terminals in the posterior pituitary gland and from somata/dendrites in the SON. Regulated exocytosis of LDCVs is considered to involve the soluble N-ethylmaleimide sensitive fusion protein attachment protein receptor (SNARE) complex [comprising vesicle associated membrane protein 2 (VAMP-2), syntaxin-1 and soluble N-ethylmaleimide attachment protein-25 (SNAP-25)] and regulatory proteins [such as synaptotagmin-1, munc-18 and Ca(2+) -dependent activator protein for secretion (CAPS-1)]. Using fluorescent immunocytochemistry and confocal microscopy, in both oxytocin and vasopressin neurones, we observed VAMP-2, SNAP-25 and syntaxin-1-immunoreactivity in axon terminals. The somata and dendrites contained syntaxin-1 and other regulatory exocytosis proteins, including munc-18 and CAPS-1. However, the distribution of VAMP-2 and synaptotagmin-1 in the SON was limited to putative pre-synaptic contacts because they co-localised with synaptophysin (synaptic vesicle marker) and had no co-localisation with either oxytocin or vasopressin. SNAP-25 immunoreactivity in the SON was limited to glial cell processes and was not detected in oxytocin or vasopressin somata/dendrites. The present results indicate differences in the expression and localisation of exocytosis proteins between the axon terminals and somata/dendritic compartment. The absence of VAMP-2 and SNAP-25 immunoreactivity from the somata/dendrites suggests that there might be different SNARE protein isoforms expressed in these compartments. Alternatively, exocytosis of LDCVs from somata/dendrites may use a different mechanism from that described by the SNARE complex theory." @default.
• W1856173697 created "2016-06-24" @default.
• W1856173697 creator A5019840028 @default.
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• W1856173697 date "2012-03-26" @default.
• W1856173697 modified "2023-10-04" @default.
• W1856173697 title "Expression of Exocytosis Proteins in Rat Supraoptic Nucleus Neurones" @default.
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• W1856173697 doi "https://doi.org/10.1111/j.1365-2826.2011.02237.x" @default.
• W1856173697 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3569506" @default.
• W1856173697 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21988098" @default.
• W1856173697 hasPublicationYear "2012" @default.
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