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- W1856245816 abstract "Nitric oxide (NO), a vital cell-signalling molecule, has been reported to regulate toxic metal responses in plants. This work investigated the effects of NO and the relationship between NO and mitogen-activated protein kinase (MAPK) in Arabidopsis (Arabidopsis thaliana) programmed cell death (PCD) induced by cadmium (Cd(2+) ) exposure. With fluorescence resonance energy transfer (FRET) analysis, caspase-3-like protease activation was detected after Cd(2+) treatment. This was further confirmed with a caspase-3 substrate assay. Cd(2+) -induced caspase-3-like activity was inhibited in the presence of the NO-specific scavenger 2-(4-carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide (cPTIO), suggesting that NO mediated caspase-3-like protease activation under Cd(2+) stress conditions. Pretreatment with cPTIO effectively inhibited Cd(2+) -induced MAPK activation, indicating that NO also affected the MAPK pathway. Interestingly, Cd(2+) -induced caspase-3-like activity was significantly suppressed in the mpk6 mutant, suggesting that MPK6 was required for caspase-3-like protease activation. To our knowledge, this is the first demonstration that NO promotes Cd(2+) -induced Arabidopsis PCD by promoting MPK6-mediated caspase-3-like activation." @default.
- W1856245816 created "2016-06-24" @default.
- W1856245816 creator A5023826377 @default.
- W1856245816 creator A5037164369 @default.
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- W1856245816 date "2012-06-14" @default.
- W1856245816 modified "2023-09-26" @default.
- W1856245816 title "Nitric oxide promotes MPK6-mediated caspase-3-like activation in cadmium-induced<i>Arabidopsis thaliana</i>programmed cell death" @default.
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- W1856245816 doi "https://doi.org/10.1111/j.1365-3040.2012.02543.x" @default.
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