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- W185631455 startingPage "135" @default.
- W185631455 abstract "The thyroid hormone receptor (TR) is a member of the nuclear hormone receptor (NHR) superfamily. These receptors are hormone-dependent transcription factors that regulate gene transcription by binding to regulatory regions of DNA termed hormone response elements (HREs) (1). TR binds to DNA in the presence or absence of its ligand, triiodothyronine (T3), and is capable of upregulating or downregulating gene transcription depending on the nature of the underlying response element. Genes that are stimulated by T3 are regulated by positive thyroid hormone response elements (pTREs); genes that are repressed by T3 are regulated by negative thyroid hormone response elements (nTREs). nTREs are particularly important in feedback inhibition in the hypothalamic-pituitary-thyroid axis, and are present in the promoter regions of the TRH, thyroid stimulating hormone β (TSHβ), and common pituitary glycoprotein α-subunit genes. TR binds to TREs as monomer, homodimer, or heterodimer with thyroid hormone receptor accessory proteins (TRAPs). In addition, TR is capable of binding to other nuclear proteins, including corepressors and coactivators, which enable it to modulate the transcription of T3-dependent genes. Thus, the presence of associated nuclear factors, as well as the nature of the underlying DNA response element, enables TR to regulate gene expression differentially." @default.
- W185631455 created "2016-06-24" @default.
- W185631455 creator A5046558877 @default.
- W185631455 creator A5049313563 @default.
- W185631455 date "2000-01-01" @default.
- W185631455 modified "2023-09-24" @default.
- W185631455 title "Thyroid Hormone Receptor Family Members" @default.
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