FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1856360008> ?p ?o ?g. }

• W1856360008 endingPage "7293" @default.
• W1856360008 startingPage "7288" @default.
• W1856360008 abstract "ABSTRACT The MDM2 oncoprotein targets the p53 tumor suppressor protein for degradation when the two proteins are expressed in cells. The regulation of p53 levels by MDM2 requires the ability of MDM2 to be exported from the nucleus by utilizing its nuclear export signal (NES). The drug leptomycin B (LMB) blocks the formation of nuclear export complexes consisting of CRM1, RanGTP, and NES-containing proteins. It is predicted that LMB should inhibit nuclear-cytoplasmic shuttling by MDM2 and subsequently stabilize p53. This communication demonstrates that LMB treatment of various cell lines led to an increase in the steady-state levels of the p53 protein as a result of an increase in its stability. The stabilized p53 protein localized to the nucleus and was an active transcription factor. These results indicate that the low steady-state levels of p53 in the absence of DNA damage result from p53’s nuclear export for cytoplasmic degradation. LMB also led to p53 stabilization in cell lines that contain human papillomavirus (HPV) DNA and express HPV E6, a protein that targets p53 for degradation. MDM2 is not necessary for E6-dependent degradation of p53, as evidenced by the observation that E6 promoted p53 degradation in cells lacking endogenous MDM2. In addition, LMB reduced E6’s ability to degrade p53 in the absence of MDM2, demonstrating that complete degradation of p53 by E6 requires nuclear export and therefore likely occurs in cytoplasmic proteasomes. These data suggest that the nuclear export of p53 to the cytoplasm for degradation is a general mechanism for regulating p53 levels." @default.
• W1856360008 created "2016-06-24" @default.
• W1856360008 creator A5031756094 @default.
• W1856360008 creator A5089778846 @default.
• W1856360008 date "1998-12-01" @default.
• W1856360008 modified "2023-10-11" @default.
• W1856360008 title "Nuclear Export Is Required for Degradation of Endogenous p53 by MDM2 and Human Papillomavirus E6" @default.
• W1856360008 cites W143775612 @default.
• W1856360008 cites W1481400971 @default.
• W1856360008 cites W1562998360 @default.
• W1856360008 cites W1576330810 @default.
• W1856360008 cites W1591281137 @default.
• W1856360008 cites W16338948 @default.
• W1856360008 cites W1822460389 @default.
• W1856360008 cites W1823168351 @default.
• W1856360008 cites W1831319429 @default.
• W1856360008 cites W192390236 @default.
• W1856360008 cites W1965173366 @default.
• W1856360008 cites W1969044026 @default.
• W1856360008 cites W1978518304 @default.
• W1856360008 cites W1986179131 @default.
• W1856360008 cites W1991494214 @default.
• W1856360008 cites W2015519364 @default.
• W1856360008 cites W2024894759 @default.
• W1856360008 cites W2038256325 @default.
• W1856360008 cites W2039382131 @default.
• W1856360008 cites W2045086385 @default.
• W1856360008 cites W2046909544 @default.
• W1856360008 cites W2056530510 @default.
• W1856360008 cites W2060786724 @default.
• W1856360008 cites W2062612693 @default.
• W1856360008 cites W2064194464 @default.
• W1856360008 cites W2072763798 @default.
• W1856360008 cites W2082979850 @default.
• W1856360008 cites W2088291944 @default.
• W1856360008 cites W2091151265 @default.
• W1856360008 cites W2097447643 @default.
• W1856360008 cites W2102930268 @default.
• W1856360008 cites W2121320998 @default.
• W1856360008 cites W2137124052 @default.
• W1856360008 cites W2138282644 @default.
• W1856360008 cites W2151160119 @default.
• W1856360008 cites W2170494099 @default.
• W1856360008 cites W2171258458 @default.
• W1856360008 cites W4247685543 @default.
• W1856360008 doi "https://doi.org/10.1128/mcb.18.12.7288" @default.
• W1856360008 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/109310" @default.
• W1856360008 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9819415" @default.
• W1856360008 hasPublicationYear "1998" @default.
• W1856360008 type Work @default.
• W1856360008 sameAs 1856360008 @default.
• W1856360008 citedByCount "494" @default.
• W1856360008 countsByYear W18563600082012 @default.
• W1856360008 countsByYear W18563600082013 @default.
• W1856360008 countsByYear W18563600082014 @default.
• W1856360008 countsByYear W18563600082015 @default.
• W1856360008 countsByYear W18563600082016 @default.
• W1856360008 countsByYear W18563600082017 @default.
• W1856360008 countsByYear W18563600082018 @default.
• W1856360008 countsByYear W18563600082019 @default.
• W1856360008 countsByYear W18563600082020 @default.
• W1856360008 countsByYear W18563600082021 @default.
• W1856360008 countsByYear W18563600082022 @default.
• W1856360008 countsByYear W18563600082023 @default.
• W1856360008 crossrefType "journal-article" @default.
• W1856360008 hasAuthorship W1856360008A5031756094 @default.
• W1856360008 hasAuthorship W1856360008A5089778846 @default.
• W1856360008 hasBestOaLocation W18563600081 @default.
• W1856360008 hasConcept C104317684 @default.
• W1856360008 hasConcept C126322002 @default.
• W1856360008 hasConcept C159047783 @default.
• W1856360008 hasConcept C16613235 @default.
• W1856360008 hasConcept C2776192174 @default.
• W1856360008 hasConcept C2779679103 @default.
• W1856360008 hasConcept C2780114586 @default.
• W1856360008 hasConcept C2994532551 @default.
• W1856360008 hasConcept C41008148 @default.
• W1856360008 hasConcept C502942594 @default.
• W1856360008 hasConcept C54355233 @default.
• W1856360008 hasConcept C54757728 @default.
• W1856360008 hasConcept C55493867 @default.
• W1856360008 hasConcept C71924100 @default.
• W1856360008 hasConcept C76155785 @default.
• W1856360008 hasConcept C81885089 @default.
• W1856360008 hasConcept C86803240 @default.
• W1856360008 hasConcept C95444343 @default.
• W1856360008 hasConceptScore W1856360008C104317684 @default.
• W1856360008 hasConceptScore W1856360008C126322002 @default.
• W1856360008 hasConceptScore W1856360008C159047783 @default.
• W1856360008 hasConceptScore W1856360008C16613235 @default.
• W1856360008 hasConceptScore W1856360008C2776192174 @default.
• W1856360008 hasConceptScore W1856360008C2779679103 @default.
• W1856360008 hasConceptScore W1856360008C2780114586 @default.
• W1856360008 hasConceptScore W1856360008C2994532551 @default.
• W1856360008 hasConceptScore W1856360008C41008148 @default.
• W1856360008 hasConceptScore W1856360008C502942594 @default.
• W1856360008 hasConceptScore W1856360008C54355233 @default.
• W1856360008 hasConceptScore W1856360008C54757728 @default.

• next