Matches in SemOpenAlex for { <https://semopenalex.org/work/W1856421120> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W1856421120 abstract "Based on encouraging treatment results with FU/FA or FU/IFN in gastrointestinal tract cancer, a phase II study was conducted to evaluate the effects and toxicity of combination FU/FA/IFN in patients (pts) with inoperable/metastatic gastric cancer.IFN 6 M.U. s.c. 1 x/week, FU 500 mg/m2 bolus i.v. 1 x/week and FA 500 mg/m2 1 x/week as a 2-hour infusion. Of 72 treated pts, 72 (22 females, 50 males) are evaluable for response and toxicity. Median age was 55.6 years (28-80), and median Karnofsky performance status was 80% (70-100). Sites of measurable disease were inoperable primary tumors/local recurrence (18), liver metastasis (22), lymph nodes (31) and peritoneum (20). One pt had bone marrow metastasis and another had paraneoplastic hyperfibrinolytic coagulopathy.10/72 pts had complete response, 20/72 pts partial response, 40/72 pts tumor stabilization and 2/72 pts progressive disease. The median duration of response (CR/PR) was 9 months, the median progression-free interval 6 months, the median survival time was 9 months, and for responding patients (CR/PR) 12.5 months.1/72 pts had WHO grade 4 toxicity (diarrhea), 5/72 pts had WHO grade 3 toxicity (nausea 1, diarrhea 4). Except for 1 treatment-limiting grade 4 toxicity, no modifications of dose or schedule due to toxicity were required. Thirty-six of 44 pts experienced a significant reduction in tumor-related pain under treatment.Biochemical modulation of FU with FA and IFN is effective in advanced gastric cancer. Moderate toxicity, outpatient treatment setting and high rates of amelioration tumor-related pain contribute to an effective palliation." @default.
- W1856421120 created "2016-06-24" @default.
- W1856421120 creator A5003741861 @default.
- W1856421120 creator A5013652918 @default.
- W1856421120 creator A5013658911 @default.
- W1856421120 creator A5014075067 @default.
- W1856421120 creator A5042199693 @default.
- W1856421120 creator A5048499083 @default.
- W1856421120 creator A5051791827 @default.
- W1856421120 creator A5060553987 @default.
- W1856421120 date "1995-02-01" @default.
- W1856421120 modified "2023-10-03" @default.
- W1856421120 title "Combination 5-fluorouracil (FU), folinic acid (FA), and α-interferon 2B in advanced gastric cancer: Results of a phase II trial" @default.
- W1856421120 cites W1583662802 @default.
- W1856421120 cites W180008295 @default.
- W1856421120 cites W1937087099 @default.
- W1856421120 cites W1940613095 @default.
- W1856421120 cites W1979300931 @default.
- W1856421120 cites W2043323962 @default.
- W1856421120 cites W2058696782 @default.
- W1856421120 cites W2090751352 @default.
- W1856421120 cites W2091283411 @default.
- W1856421120 cites W2111718148 @default.
- W1856421120 cites W2256038834 @default.
- W1856421120 cites W2269247374 @default.
- W1856421120 cites W2412521257 @default.
- W1856421120 cites W2464890361 @default.
- W1856421120 doi "https://doi.org/10.1093/oxfordjournals.annonc.a059110" @default.
- W1856421120 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7540418" @default.
- W1856421120 hasPublicationYear "1995" @default.
- W1856421120 type Work @default.
- W1856421120 sameAs 1856421120 @default.
- W1856421120 citedByCount "8" @default.
- W1856421120 countsByYear W18564211202019 @default.
- W1856421120 crossrefType "journal-article" @default.
- W1856421120 hasAuthorship W1856421120A5003741861 @default.
- W1856421120 hasAuthorship W1856421120A5013652918 @default.
- W1856421120 hasAuthorship W1856421120A5013658911 @default.
- W1856421120 hasAuthorship W1856421120A5014075067 @default.
- W1856421120 hasAuthorship W1856421120A5042199693 @default.
- W1856421120 hasAuthorship W1856421120A5048499083 @default.
- W1856421120 hasAuthorship W1856421120A5051791827 @default.
- W1856421120 hasAuthorship W1856421120A5060553987 @default.
- W1856421120 hasBestOaLocation W18564211201 @default.
- W1856421120 hasConcept C121608353 @default.
- W1856421120 hasConcept C126322002 @default.
- W1856421120 hasConcept C141071460 @default.
- W1856421120 hasConcept C2776694085 @default.
- W1856421120 hasConcept C2776907518 @default.
- W1856421120 hasConcept C2778496288 @default.
- W1856421120 hasConcept C2778822529 @default.
- W1856421120 hasConcept C2779013556 @default.
- W1856421120 hasConcept C2779804826 @default.
- W1856421120 hasConcept C2780456651 @default.
- W1856421120 hasConcept C2780580376 @default.
- W1856421120 hasConcept C29730261 @default.
- W1856421120 hasConcept C31760486 @default.
- W1856421120 hasConcept C71924100 @default.
- W1856421120 hasConcept C90924648 @default.
- W1856421120 hasConceptScore W1856421120C121608353 @default.
- W1856421120 hasConceptScore W1856421120C126322002 @default.
- W1856421120 hasConceptScore W1856421120C141071460 @default.
- W1856421120 hasConceptScore W1856421120C2776694085 @default.
- W1856421120 hasConceptScore W1856421120C2776907518 @default.
- W1856421120 hasConceptScore W1856421120C2778496288 @default.
- W1856421120 hasConceptScore W1856421120C2778822529 @default.
- W1856421120 hasConceptScore W1856421120C2779013556 @default.
- W1856421120 hasConceptScore W1856421120C2779804826 @default.
- W1856421120 hasConceptScore W1856421120C2780456651 @default.
- W1856421120 hasConceptScore W1856421120C2780580376 @default.
- W1856421120 hasConceptScore W1856421120C29730261 @default.
- W1856421120 hasConceptScore W1856421120C31760486 @default.
- W1856421120 hasConceptScore W1856421120C71924100 @default.
- W1856421120 hasConceptScore W1856421120C90924648 @default.
- W1856421120 hasLocation W18564211201 @default.
- W1856421120 hasLocation W18564211202 @default.
- W1856421120 hasOpenAccess W1856421120 @default.
- W1856421120 hasPrimaryLocation W18564211201 @default.
- W1856421120 hasRelatedWork W1981794048 @default.
- W1856421120 hasRelatedWork W1997366816 @default.
- W1856421120 hasRelatedWork W2005605711 @default.
- W1856421120 hasRelatedWork W2031477213 @default.
- W1856421120 hasRelatedWork W2041959320 @default.
- W1856421120 hasRelatedWork W2072252734 @default.
- W1856421120 hasRelatedWork W2134112440 @default.
- W1856421120 hasRelatedWork W2146934240 @default.
- W1856421120 hasRelatedWork W2412036272 @default.
- W1856421120 hasRelatedWork W2439099766 @default.
- W1856421120 isParatext "false" @default.
- W1856421120 isRetracted "false" @default.
- W1856421120 magId "1856421120" @default.
- W1856421120 workType "article" @default.